Alain Dagher

@alaindagher.bsky.social

Neurology and brain imaging. ORCID: 0000-0002-0945-5779

Our first Impact Factor is 3.0 — an important milestone for a new journal. As with most new journals, the first IF is affected by the smaller publication volume in the launch year. Latest citation data are encouraging, and the journal’s IF is set to rise in 2027.

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Quebec nationalists all oppose the proposed high speed rail between Montreal and Toronto. Of course, they hate anything that means openness and connection to the world. They are reactionaries who want us to be a village, physically and culturally. montrealgazette.com/news/provinc...

PQ would block high-speed rail link from Quebec City to Toronto, wants federal money instead

“I have the impression the PQ doesn’t understand how this works,” Premier Christine Fréchette responded.

montrealgazette.com

Parkinson’s disease may not be just one disease protein. New paper in Movement Disorders shows how Parkinson’s disease frequently includes overlapping pathologies such as tau, beta amyloid, TDP-43, vascular disease and inflammation, in addition to alpha-synuclein.

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Training at MSKCC I heard from Jerry Posner, Josep Dalmau, Bob Darnell etc... about autoimmune paraneoplastic syndromes. They observed that the cancers tended to be kept in check. This led to the hope that we could treat cancer with immunotherapy. This promise is now starting to be realized.

Isaac Bogoch@isaacbogoch.bsky.social · 4mo ago

mRNA vaccines continue to show major promise. In a small Phase 1 trial led by Dr. Balachandran, some patients with pancreatic cancer (one of the deadliest cancers) reached 6-year survival. This is why sustained investment in science & research matters. tinyurl.com/f4n4anhk

After two years I finally got an appointment with a Family Physician. An AI would have done a better job. At the risk of generalizing, Quebec Health care may well be the worst in the developed world.

Correlating brain maps across datasets is everywhere in neuroimaging. Here we ask: when you contextualize a brain map against genes, metabolism, or connectivity... What can you really conclude? How can we do better? We explore these questions here: tinyurl.com/2dudkevc

Opportunities and pitfalls of data contextualization in neuroimaging - Nature Reviews Neuroscience

Despite rapid exploitation of the opportunities that contextualization of brain maps affords, potential limitations have received little attention. In this Roadmap, Royer et al. provide practical guid...

tinyurl.com

Kraepelin was right all along. We may need to think of schizophrenia along a neurodevelopmental - neurodegenerative axis. "This study accords with previous work suggesting that dementia is a common outcome of schizophrenia and may arise from the illness itself."

JAMA Psychiatry@jamapsychiatry.com · 4mo ago

Among individuals with severe, treatment-resistant #Schizophrenia, dementia was common and showed a distinct clinical and genetic profile not explained by Alzheimer disease, cardiovascular risk, or medication effects. ja.ma/4bWZlcz

The image presents clock-drawing tests with varying MoCA scores(2-16), education levels(5th-college), ages(35-67), and years hospitalized(7-46). Drawings range from incomplete circles with few numbers to more accurate clock faces, reflecting cognitive abilities.