1/ 🚨 Just out in @natneuro.nature.com! 🧠 We profiled >6,000 features of brain dynamics across humans, macaques, marmosets, mice, fish and worms 🧑🐒🐒🐁🐟🪱 to find a shared neural endpoint of anaesthesia: spatiotemporal isolation of local activity 🧵👇 🔗 doi.org/10.1038/s41593-026-02460-4
Bratislav Misic
@misicbata.bsky.social
Montreal Neurological Institute - McGill University https://netneurolab.github.io/
So excited that our work is now published in PLOS Biology!! 🎉 Check out the final version here: doi.org/10.1371/jour... And for a bit more context and what we found, here’s our earlier thread: bsky.app/profile/goli...
How do intrinsic timescales, which reflect the temporal window of neural processing, mature during development? This study by @goliashf.bsky.social @ted-satterthwaite.bsky.social &co identifies a hierarchical trajectory, from sensorimotor to association cortices. 🧪 #NeuroSky plos.io/46RzqRG
I can't overstate the importance of this toolbox & this paper! Really amazing stuff
netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1038/s415... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging @natprot.nature.com ⤵️
Spatial organization of AQP4 water channel expression in the human brain | doi.org/10.1126/scia... Aquaporins are a key component of the glymphatic system. How are they distributed + how do they relate to brain function and dysfunction? ⤵️
Spatial organization of AQP4 water channel expression in the human brain
Aquaporin-4 (AQP4) water channels support the glymphatic system, a brain-wide pathway that clears cerebral waste products. Here, we use AQP4 gene expression to reconstruct a whole-brain glymphatic-rel...
doi.org
netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1038/s415... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging @natprot.nature.com ⤵️
netneurotools: a trainee-oriented approach to network neuroscience - Nature Protocols
This is a Perspective covering a Python toolbox for neuroscience research that enables users to fetch datasets, construct networks and null models, estimate graph metrics, fit statistical models and v...
doi.org
netneurotools is a Python toolkit that has been continuously developed by lab trainees as a set of tools to navigate the complex informatics ecosystem of brain imaging. @natprot.nature.com @misicbata.bsky.social 🧪 🧠 #imaging
netneurotools: a trainee-oriented approach to network neuroscience - Nature Protocols
This is a Perspective covering a Python toolbox for neuroscience research that enables users to fetch datasets, construct networks and null models, estimate graph metrics, fit statistical models and v...
nature.com
#Aging drives changes in the #brain and #metabolism, but how independent are these effects? This study by @asafarahani.bsky.social, @misicbata.bsky.social &co identifies two axes of brain-body associations, each primarily related to age or metabolic health. 🧪#AcademicSky plos.io/4eoIu3L
#Aging drives changes in the #brain and #metabolism, but how independent are these effects? This study by @asafarahani.bsky.social, @misicbata.bsky.social &co identifies two axes of brain-body associations, each primarily related to age or metabolic health. 🧪#AcademicSky plos.io/4eoIu3L
Our latest, led by @ivaili.bsky.social out now in Nature Mental Health using normative modelling to understand the heterogeneity of atypical FC in autism. Peep the thread...
Our paper “Multiscale heterogeneity of atypical functional connectivity in autism” is now out in Nature Mental Health www.nature.com/articles/s44... With @alexfornito.bsky.social, Jan Buitelaar, Marianne Oldehinkel
Do humans show sex differences in brain activation? If so, are these task-specific or general — and do they relate to sex differences in brain anatomy and behavior? We dove deep into these questions in a new paper just out in Nature Communications | tinyurl.com/3rdrb524
Delighted that our paper about benchmarking gene expression 🧬 in macaque brain 🐒🧠(www.science.org/doi/10.1126/...) was selected for this year's Brain Star Award of the Canadian Neuroscience Association 🇨🇦 - what an honour to be named among such talented scientists!
science.org
CAN and CIHR-INMHA are very proud to announce the winners of the 2025 Brain Star awards. See all their profiles here: can-acn.org/congratulati...
My most recent and biggest work so far is finally out as a preprint! 🧠🧵 *Linking human brain functional connectivity to underlying neurotransmission* doi.org/10.64898/202... 1/n TL;DR below ↓ #neuroskyence #neuroimaging #MedSky #PsySciSky
Benchmarking spatial interpolation methods for brain maps https://www.biorxiv.org/content/10.64898/2026.04.27.721143v1
Comparative anatomy of brain metabolism in human and macaque (and other species). The dichotomy between glucose as fuel and glucose for tissue building is conserved across species. @moohebatpe.bsky.social and @misicbata.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
We develop a new TMS targeting algorithm and test it in an open label trial in a treatment-resistant depression population with high comorbidities. Preprints by @rubykong92.bsky.social Phern-Chern Tor 1. doi.org/10.1101/2025... 2. doi.org/10.64898/202... Our new approach ...
Structure-function coupling in the human brainstem https://www.biorxiv.org/content/10.64898/2026.04.05.716603v1
Do you censor high motion frames in fMRI? In two preprints by @twktan.bsky.social @mandymejia.bsky.social, we find that we may be censoring too much! doi.org/10.64898/202... arxiv.org/html/2603.07... Strict censoring leads to worse personalized TMS targets than no censoring, even with high motion!
Our lab has an opening for a full-time research assistant, to work on human neuroimaging techniques and the neuroscience of sleep! To apply: massgeneralbrigham.wd1.myworkdayjobs.com/en-US/MGBExt...
Clinical Research Coordinator
Site: The General Hospital Corporation Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to adva...
massgeneralbrigham.wd1.myworkdayjobs.com
Curious about how brain and body communicate, or how circuit states are regulated over seconds to hours? Read our paper about neuropeptide systems and how they contribute to neural architecture and function #neuroskyence #compneuro #neuroscience
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415... Neuropeptides are functionally diverse signaling molecules in the brain and body. @cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
📢 New preprint from the lab🧠 ▶️doi.org/10.64898/2026.03.12.710517 What does fMRI connectivity actually reflect at the neural level? The natural intuition is: more neural activity = more connectivity! Using cortical perturbations we show this is not necessarily the case: sometimes less is more! 👇🧵
Our work on gene therapy for creatine transporter deficiency is now online in #Brain ➡️https://doi.org/10.1093/brain/awaf275 In this study we (i) characterize network-level and behavioral alterations in a common form of monogenic #autism and (ii) test whether gene therapy can rescue these deficits 🧵
The program is coming together well for the Brain Connectivity Workshop www.bcw2026.org/program. This will be our 25th year! Consider coming just before the #OHBM annual meeting. #Neuroscience
Program — BCW 2026: June 10-12
bcw2026.org
Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415... Neuropeptides are functionally diverse signaling molecules in the brain and body. @cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️
Just out in @natneuro.nature.com! 🧠 “Competitive interactions shape mammalian brain network dynamics and computation” www.nature.com/articles/s41... Is large-scale brain communication purely cooperative — or is competition a core organizing principle? We built 🧠 models to find out: read on🧵👇
Competitive interactions shape mammalian brain network dynamics and computation - Nature Neuroscience
Brain network architecture may balance cooperation and competition across circuits. Here the authors use computational whole-brain modeling across three species to show that models with competition ar...
nature.com
🚀 We are hiring: a PhD position is available in my lab (gozzilab.it) at @iitalk.bsky.social, Italy. Project: large-scale brain network mapping in behaving mice using functional ultrasound imaging (FUSI). 📅 Deadline: March 31 🔗 tinyurl.com/4jtetxa9 Reshares appreciated 😊
Synaptome architecture shapes regional dynamics in the mouse brain | doi.org/10.1371/jour... How do diverse synapses relate to the spatial patterning of whole-brain dynamics? Justine Hansen explores @plosbiology.org ⤵️
Spatial organization of AQP4 channels in the human brain: links with perfusion, edema, and disease vulnerability | doi.org/10.64898/202... Aquaporins are a key component of the brain’s glymphatic system. How are they distributed and how do they relate to healthy brain function and dysfunction? ⤵️
🚨Another new one from the lab! Cascades and convergence: Dynamic signal flow in a synapse-level brain network We simulate sensory cascades in a bona fide biological neural network. With Caio Seguin, Maria Grazia Puxeddu, and @misicbata.bsky.social! journals.plos.org/complexsyste...
Cascades and convergence: Dynamic signal flow in a synapse-level brain network
Author summary To understand how the brain processes and merges information from our senses, we need more than just a “wiring map” of its connections; we need to see how signals actually travel throug...
journals.plos.org
fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs) But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995 🧵1/n