Alan Bince Jacob

@alanbince.bsky.social

Doctoral Candidate - Dept. of Neuropsychology & Psychopharmacology, Maastricht University | Neuroscience in Human Movement | Research: Cognitive Control, Predictive Coding, Posture/Gait | Personal views only

📣📣📣 Preprint Alert! 📣📣📣 Do predictive processes shape brain representations during learning? We investigated the effect of Predictive Coding by training identical recurrent networks with different optimization procedures and then comparing them to human EEG under the same visual learning task.

Overview figure of our learning paradigm, architecture, and analysis procedure.

How do #learning processes related to reward exploitation and exploration interact with one another in the brain? This study uses behavior, neuroimaging, pharmacology, and modeling to reveal shared learning mechanisms, connecting with individual traits and experiences 🧪#AcademicSky plos.io/4fDkj27

Relationship between reward-learning interference and exploration-associated neural responses. The images show brain models on the left with regions of differential activity highlighted. Graphs on the right show significant correlations between neural activity patterns and behavior.

Using general linear model (GLM) 2 (see Materials and methods), dorsomedial prefrontal cortex (dmPFC) exhibited significant activations during exploration (contrast “Exploration> Exploitation”). Activated clusters were corrected for multiple comparisons at the whole-brain level (cluster-forming threshold of p < 0.001, and a cluster-level familywise error rate of p < 0.05). The color bar shows SPM-derived t scores. See S5 Table for details. Based on GLM3 (see Materials and methods), the BOLD signal extracted from the suprathreshold dmPFC clusters significantly covaried with the reduction in correct rates in reward-learning interference (RLINT) vs. reward-learning control (RLCON) trials.

A recent @natneuro.nature.com paper analyzed lesion network mapping and raised concerns about the validity of the method. See below 👇 for our response. www.biorxiv.org/content/10.6...

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Michael Fox@foxmdphd.bsky.social · 8mo ago

A recent paper in @natureportfolio.nature.com raised concerns about the lesion network mapping method. Our team of 16 coauthors analyzed >1000 lesions and 34 symptoms and found that "The methodological foundations of lesion network mapping remain sound" www.biorxiv.org/content/10.6...

We regret to inform you that your paper cannot be considered for publication, but we encourage you to submit it to our GOLD Open Access sister journal