Alan Yu
@alanyuneph.bsky.social
Nephrologist, physician-scientist. Director, Division of Nephrology, Jared Grantham Kidney Institute, University of Kansas. Opinions are my own. #NephSky
Bone marrow-derived inflammatory signals may shape glomerular disease in ways that we are only beginning to understand. Read this article in #ASNKidneyNews following one of the most prominent and debated candidates, suPAR: kidney.pub/KN1802-15
🔥Proud to share our latest #PKD prognostic model from CRISP IV In ADPKD pts with normal eGFR we can predict probability of kidney failure 15 years later with C-index >0.8 Uses only TKV + data obtained in usual clinical care
ASN Publications@asnpublications.bsky.social · 10mo agoAutosomal dominant polycystic kidney disease (ADPKD) is a common cause of kidney failure. This #ASNJASN study developed a multivariable predictive model for progression to kidney failure: kidney.pub/JASN0950 @alanyuneph.bsky.social
Autosomal dominant polycystic kidney disease (ADPKD) is linked to mutations in PKD1 and PKD2 genes, affecting cation channel complexes in kidney cell cilia. This #ASNJASN study explored ways to increase these complexes in cilia to prevent kidney cyst formation: kidney.pub/JASN0942
Cystogenesis and interstitial fibrosis are contributing factors to kidney failure in individuals with ADPKD. This #ASNJASN research examines the role of Integrin Alpha1 Beta1 in a mouse model: kidney.pub/JASN0941 #BasicResearch @rachellennon.bsky.social
Honored to have @juancarlosqvelez.bsky.social visiting KU Nephrology and the Jared Grantham Kidney Institute. Fantastic lecture on #hepatorenal syndrome (of course)👏 Lots of practical recommendations backed up by research conducted by Dr. Velez at @ochsnerhealth.bsky.social
~15 years ago, Dr. Fred Coe put forward the “vas washdown” model for explaining kidney stone formation @alanyuneph.bsky.social & team now report on a new mouse model, showing kidney-specific Cldn-2 KO leads to medullary nephrocalcinosis—supporting the vas washdown model: doi.org/10.1172/JCI1...
Now out @jclinicalinvest led by Christine_Behm with fantastic team of collaborators👇 We discover a corticomedullary gradient for Ca in kidney and show a critical role for claudin-2, with implications for kidney stone disease. @kumedcenter.bsky.social www.jci.org/articles/vie...
Join us in congratulating this winner of the Distinguished Leader Award, an ASN Midcareer Award: Reem A. Mustafa, MD PhD MPH FASN. Read more about her work in #ASNKidneyNews: kidney.pub/KN1710-41
New podcast alert! Dr. Priya Vart discusses the results of his study, “Effects of Dapagliflozin on Health-Related Quality of Life in Patients with CKD,” with #ASNJASN Deputy Editor Manjula Kurella Tamura: kidney.pub/JPOD0776
And in the evening - a CAR T in refractory SLE - a PKD trial - increasing PD in Vets - Povetacicept in IgA - TESTING Longterm term data - what do the AHA/ACC BP guidelines mean? #KidneyWk
Starting Soon! Join us for the 2025 Best of ASN Journals session at #KidneyWk. Join us Tomorrow, Thursday, November 6 at 2:00 PM in Grand Ballroom A of the George R. Brown Convention Center for a lively discussion and check out the article collection below. kidney.pub/BestOf2025
The 2025 #ASNJASN #ASNCJASN and #ASNKidney360 Trainees of the Year are Benoit Brilland, Thomas Bais, and Yuhei Noda! This prize celebrates the best article submitted to each journal by a trainee as the first author. See more about the contest and this year's winners: kidney.pub/TraineeOf...
New in #ASNJASN: an epigenetic CRISPR Screen was used for the first time to identify critical genes and pathways involved in vascular calcification. kidney.pub/JASN0793
NEW on the #AJKDBlog: @maximalchange.bsky.social interviews the authors of a recent review of ADPKD, Sara S. Jdiaa and Reem A. Mustafa, and discusses prognosis, goals, and monitoring. bit.ly/Jdiaa25 (FREE)
In a recent #ASNJASN article, authors report that ephrin-B1 at slit diaphragm suppresses cdc42 activity by preventing the interaction of Par6 with cdc42 and functions to keep the specialized phenotype of podocytes. Read more: kidney.pub/JASN0728 #BasicResearch
Genetically modified gut bacteria show promise of combating kidney stones in clinical trial medicalxpress.com/news/2025-07...
Genetically modified gut bacteria show promise for combating kidney stones in clinical trial
The human gut microbiome has been shown to impact health in a myriad of ways. The type and abundance of different bacteria can impact everything from the immune system to the nervous system. Now, rese...
medicalxpress.com
NEW on the #AJKDBlog: @maximalchange.bsky.social interviews the authors of a recent review of ADPKD, Sara S. Jdiaa and Reem A. Mustafa, and discusses prognosis, goals, and monitoring. bit.ly/Jdiaa25 (FREE)
⏳ One week left to apply. The Fellows’ Travel Support Scholarship gives nephrology fellows $1,000 to attend the UAB CRRT Academy. Train in person, build practical CRRT skills, and learn through simulation and expert-led sessions. Apply by Monday, July 21 👉 bit.ly/3FGntEx
Guidelines no longer recommend holding typical first-line antihypertensive meds since renin will most often still be suppressed despite being on them in true PA. Growing evidence supports proceeding with screening Hot off the press from the Endo Society: www.endocrine.org/clinical-pra...
Primary Aldosteronism
A new Endocrine Society guideline on Primary Aldosteronism updates a 2016 guideline, and suggests that everyone who is diagnosed with hypertension have their levels of aldosterone, renin, and potassiu...
endocrine.org
Could gene-targeted therapy be coming for autosomal dominant polycystic kidney disease? Farabursen, a new medication acquired by Novartis offers to potentially impact cyst formation and even regression. kidney.pub/KN1707-07 #ASNKidneyNews @nephrosparks.bsky.social
𝗡𝗘𝗪 𝗥𝗘𝗦𝗢𝗨𝗥𝗖𝗘 𝗔𝗟𝗘𝗥𝗧: Download our #ADPKD infographic for a quick overview of diagnosis, delaying progression, complications & more. A handy resource for clinicians and patients alike! ⬇️https://www.theisn.org/wp-content/uploads/2025/07/ADPKD-Infographic.pdf
🔥Submit a Late-Breaking Clinical Trial and have your study considered for contemporaneous publication in JASN, NEJM @nejm.org or Lancet @thelancet.com
ASNKidney@asnkidney.bsky.social · last yr.📣 The call for Late-Breaking Clinical Trials is open for ASN #KidneyWk 2025! Submit Phase 2, 3, or 4 clinical trials to present this November in Houston and reach 12,000+ kidney health professionals. 🗓️ Deadline: Tuesday, September 9, at 2:00 p.m. EDT 🔗 asn.kdny.info/Kbvo50WqwvO
Understanding the role of alternative splicing in podocyte biology may lead to theraputic options for patients with glomerular hypertension. Read more in a #BasicResearch article: kidney.pub/JASN0706 #ASNJASN
The 2026 RFAs for grant and fellowship awards from @pkdfoundation.bsky.social are out! Grant: pkdcure.org/research/gra... Fellowship: pkdcure.org/research/fel... LOIs are due August 11. Send us your best ideas!!
Grant Applications - Polycystic kidney disease | PKD treatment research | PKD Foundation
PKD Foundation Research RFA - With PKD Connect, no one will ever face polycystic kidney disease alone. Because patients, family and loved ones will always be connected to others who understand firstha...
pkdcure.org
The June issue of JASN is now available online! Topics covered include: - Blood Transfusion during Myocardial Infarction in CKD - COL4A5 Variants in an Unselected Health System Population - and more Check out the issue: journals.lww.com/jas... #ASNJASN Cover by @ecorneclegall.bsky.social et al.
Looks like the consolidation of NIDDK, NHLBI and NIAMS into “NI on Body Systems” proposed combined budget cut of 41%. #medsky #maha
Swapnil Hiremath 🍁🇨🇦@hswapnil.medsky.social · last yr.No more NIDDK or NHLBI, combined into one institute www.hhs.gov/sites/defaul... h/t @jbrianbyrd.bsky.social #MedSky
New Podcast: Dr. Tobias Hermle & Dominik Spitz discuss a proof-of-concept for whole-animal drug screening using podocyte-like Drosophila nephrocytes. Pilot screen using the novel podocytopathy platform identifies that zacopride restores slit diaphragms despite excess of Rac1. https://bit.ly/JPOD0677
A powerful technique that directly edits proteins in living cells promises to help researchers to study proteins in improved ways. https://go.nature.com/3GyiDJn
Powerful protein editors offer new ways of probing living cells
Scientists deploy self-splicing protein subunits to insert strange new additions into target proteins.
go.nature.com