Alberto Sanz
@albertosanzmon1.bsky.social
A scientist researching aging. Passionate about unlocking all forms of knowledge. Championing technology as a catalyst for human progress.
Latest publication from Mario Cordero's lab: NLRP3 haploinsufficiency unmasks a compensatory NLRP1-NLRP3 interaction that drives accelerated aging in mice | Science Advances www.science.org/doi/10.1126/... with a modest contribution from yours truly ;-)
science.org
My son is raising money for @msf.ca. Please help by donating and spreading the word 🙏🏻 www.justgiving.com/page/ivan-ko...
100km Ultramarathon for Medical Care in Crisis Zones
Help Ivan Korolchuk raise money to support Medecins Sans Frontieres / Doctors Without Borders (MSF)
justgiving.com
Funding? I'm a simple academic, so I'll have to await someone smart to explain to me how "pausing" MRC and BBSRC funding is the action of a biomedical science superpower...?
😂 and this is after a full round of review at Nature... read the paper anyway, it's still good :) www.biorxiv.org/content/10.1...
Proteome-wide Prediction of the Functional Impact of Missense Variants with ProteoCast
Background Dissecting the functional impact of genetic mutations is essential to advancing our understanding of genotype-phenotype relationships and identifying new therapeutic targets. Despite the pr...
biorxiv.org
A welcome finish to what has been, & continues to be, a rough year. Proud to have been a (small) part of this work published in @elife.bsky.social, which, as always from the Dobson Lab, is meticulous, thorough & insightful.
Microbiota impact Drosophila ageing via Acetobacter, Tachykinin, and TkR99D
doi.org
PhD studentship at @glasgow.ac.uk #Mitochondria × #spectroscopy × #machinelearning. Detect mitochondrial defects, estimate age, and identify anti-ageing drugs across species. Supervisors: @albertosanzmon1.bsky.social @mariogonzalez.es & @nealdawson.bsky.social UK Home fees only. shorturl.at/wvMQa
Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy. doi.org/10.1038/s441...
Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia - Nature Cardiovascular Research
Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...
doi.org
We have updated a previous preprint from our laboratory, and after two additional years of experiments, we now present new findings that fundamentally reshape how we—meaning us, not necessarily everyone—understand ageing. www.biorxiv.org/content/10.1...
Developmental Programming of Mitochondrial Function Limits Lifespan in Short-Lived Animals
The contribution of mitochondria to lifespan determination remains controversial, as impaired mitochondrial function can paradoxically both shorten and extend longevity. During ageing, mitochondria ac...
biorxiv.org
We have updated a previous preprint from our laboratory, and after two additional years of experiments, we now present new findings that fundamentally reshape how we—meaning us, not necessarily everyone—understand ageing. www.biorxiv.org/content/10.1...
Developmental Programming of Mitochondrial Function Limits Lifespan in Short-Lived Animals
The contribution of mitochondria to lifespan determination remains controversial, as impaired mitochondrial function can paradoxically both shorten and extend longevity. During ageing, mitochondria ac...
biorxiv.org
Two weeks left to apply for a PhD position in my laboratory at #Glasgow. The project focuses on #Ageing, #Mitochondria, and #Drosophila, with emphasis on Complex I (CI) function. Fees are fully covered for applicants eligible for UK Home Student status. www.findaphd.com/phds/project...
FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow on FindAPhD.com
PhD Project - FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow, listed on FindAPhD.com
findaphd.com
There is a PhD Studentship in my laboratory starting in March 2026. Please contact me if you are interested. www.findaphd.com/phds/project...
FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow on FindAPhD.com
PhD Project - FULLY FUNDED PhD - Identifying Critical Periods for Mitochondrial Function in Drosophila Development and Lifespan at University of Glasgow, listed on FindAPhD.com
findaphd.com
ROS Signalling, not ROS Damage: A new Paradigm in Ageing youtu.be/yt1kiuOyNtY?... via @YouTube #Aging #ROS #Drosophila #Mitochondria
ROS Signalling, not ROS Damage: A new Paradigm in Ageing
YouTube video by The Sanz Science Experience
youtu.be
Exciting news! Our most important work is out as preprint! We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use. Next step is the clinical trial starting early next year! www.medrxiv.org/content/10.1...
Pluripotent stem cell-based drug discovery uncovers sildenafil as a treatment for mitochondrial disease
Mitochondrial disease encompasses inherited disorders affecting mitochondrial function. A severe and untreatable form of mitochondrial disease is Leigh syndrome (LS) causing psychomotor regression and...
medrxiv.org
NAD+ Boosters: Slowing Aging or Selling Hype? youtu.be/0QxzAz9B--Y?... via @YouTube #aging #healthyaging #NAD+ #NADH #muscle #supplements #hype
NAD+ Boosters: Slowing Aging or Selling Hype?
YouTube video by Science Sanz Hub
youtu.be
What's Aging? A Survey Among Professionals youtu.be/iX_QUwrHkfY?... via @YouTube #aging #surve #disagreement
What's Aging? A Survey Among Professionals
YouTube video by Science Sanz Hub
youtu.be
NAD+ Boosters: Slowing Aging or Selling Hype? youtu.be/0QxzAz9B--Y?... via @YouTube #aging #healthyaging #NAD+ #NADH #muscle #supplements #hype
NAD+ Boosters: Slowing Aging or Selling Hype?
YouTube video by Science Sanz Hub
youtu.be
Age Deceleration and Reversal in C elegans youtu.be/QSmpKDEjYNA?... #aging #worms #celegans #dauer
Age Deceleration and Reversal in C elegans
YouTube video by Science Sanz Hub
youtu.be
How does a Fly Die? And why should we care? #Drosophila #Aging #Biology youtu.be/-akcyD68-eA?...
How Does a Fly Die? And why should we care?
YouTube video by Science Sanz Hub
youtu.be
A concise and excellent summary of our recent @emboreports.org manuscript, now published in @natsmb.nature.com. www.nature.com/articles/s41...
Timing of complex I activity and lifespan control - Nature Structural & Molecular Biology
Nature Structural & Molecular Biology - Timing of complex I activity and lifespan control
nature.com
New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.
Developmental mitochondrial complex I activity determines lifespan | EMBO reports
imageimageTemporal manipulation of CI function reveals development as critical window where reduction of CI produces short-lived and stress sensitive adults characterised by maladaptive transcriptomic...
embopress.org
A podcast discussing our paper on the role of CI on aging and mitochondrial disease: www.youtube.com/watch?v=Usu7...
Timing Mitochondrial Dysfunction: The Key to Regulating Aging
YouTube video by Science Sanz Hub
youtube.com
New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.
Developmental mitochondrial complex I activity determines lifespan | EMBO reports
imageimageTemporal manipulation of CI function reveals development as critical window where reduction of CI produces short-lived and stress sensitive adults characterised by maladaptive transcriptomic...
embopress.org