New preprint! Introducing DIMPLE-GWAS - a new dimensionality-reduction method to capture latent endophenotypes. Applied to pleiotropic brain imaging data in UK Biobank, we developed a new brain atlas composed of 25 core "clusters" Details below and at my #SOBP talk Sat 3pm

New Year, New Paper! #PolygenicEmbryoScreening We examined the interaction of rare and common variation for breast cancer in the context of PES, with three key findings detailed in posts below...

Check out the paper for demonstrations of this effect in simulations and three datasets. We need to understand how PGS perform in clinical settings if they are ever to be useful as predictive markers, which is what we are trying to accomplish with the FEP-GEN consortium. 5/6

Polygenic embryo screening is being marketed commercially – but how do IVF clinicians view it? • General approval is low (12%) For specific uses: • 59% approved of health-related embryo selection • 6% approved of trait-based selection 🧵 Survey findings in NPJ Genomic Medicine

Greetings #WCPG2025 from Cancun! If you’re at the meeting and looking for a postdoctoral or research scientist position, come find me at poster M66 tonight!

Please see our new work, led by @shaicarmi.bsky.social - in addition to a free online risk calculator, we demonstrate (for the first time), the degree to which real-world live birth rates attenuate the potential risk reduction in polygenic embryo screening (PES)

Shai Carmi@shaicarmi.bsky.social · 11mo ago

Excited to present our new tool "PEStimate", an online app for predicting risk reductions after Polygenic Embryo Screening (PES). Find the app here: polygenicembryo.shinyapps.io/pestimate/ Preprint: www.medrxiv.org/content/10.1...

We lay out three consensuses from the field of psychiatric genetics that should be considered before approving genetic tests for psychiatric disorders. The letter was signed by 140 experts in psychiatric genetics and published in Lancet Psychiatry. Now on Pubmed: pmc.ncbi.nlm.nih.gov/articles/PMC...

Concerns About Genetic Risk Testing for Opioid Use Disorder

pmc.ncbi.nlm.nih.gov

New publication! We expand on our prior work demonstrating that pleiotropic effects of cognitive GWAS can provide biological insights into schizophrenia GWAS results. We differentiated "concordant" from "discordant" subsets of schizophrenia risk SNPs (1/3)

A very thoughtful and comprehensive piece on polygenic embryo screening in today's NY Times: www.nytimes.com/interactive/...

Opinion | I.V.F., Gene Selection and Embryo Screening: Is This the Future of Making Babies? (Gift Article)

Advances in genetic testing and artificial intelligence are changing what’s possible for those undergoing I.V.F. Are we ready for the future of fertility?

nytimes.com

Re-upping for the early crowd - link in reply

Todd Lencz@toddlencz.bsky.social · last yr.

New Paper! Online now in JAMA Psychiatry, we have performed a large-scale Mendelian Randomization study of circulating proteins in schizophrenia, bipolar disorder, major depression, and cognitive task performance.

New Paper! Online now in JAMA Psychiatry, we have performed a large-scale Mendelian Randomization study of circulating proteins in schizophrenia, bipolar disorder, major depression, and cognitive task performance.

Unsure how recent changes in U.S. policy regarding the NIH will impact the psychiatric genetics world? You're not alone. Join ISPG for a Member’s Meetup for community discussion and support: 📅 Wednesday, January 29 🕗 3 PM EST 📍 Pre-Register: us06web.zoom.us/meeting/regi...

On my way to #ACNP2024 🌵 Now recruiting for a #postdoc position in psychiatric genetics: t.co/Stst3V9agM If you are interested in the genetics of psychotic disorders and their endophenotypes, check out my poster M160 on Monday!

Neuropsychopharmacology@npp-journal.bsky.social · 2y ago

We are officially on the ground in Phoenix so it's time for the #ACNP2024 role call 📣 Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️

Guess who's joining the party over here?? 🎉🦋 @npp-journal.bsky.social @dpn-journal.bsky.social & @acnporg.bsky.social Be sure to follow☝️ahead of #ACNP2024

a man in a sweater is standing in front of a door with christmas wreaths on it .

ALT: a man in a sweater is standing in front of a door with christmas wreaths on it .

media.tenor.com

I think this JAMA article from last week received insufficient attention - different computations of PRS for the same disease, despite nearly identical population performance, resulted in very different classifications at the individual level #polygenicriskscores jamanetwork.com/journals/jam...

Evaluating Performance and Agreement of Coronary Heart Disease Polygenic Risk Scores

This study aims to characterize the individual-level agreement of polygenic risk scores for coronary heart disease that perform similarly at the population level.

jamanetwork.com

NOW HIRING #postdocjobs NIH funding for a #postdoc with interest in complex genetics / computation / analysis #GWAS #rarevariants #polygenicriskscores in multiple research contexts: psychiatric genomics; cognitive genomics; embryo screening... acnp.org/wp-content/u...

Just added the 106th amazing statistical/psychiatric geneticist! Even if you have seen this starter pack before have a look, find the new people filtering in!

Ok friends! I made a starter pack of psychiatric genetics people! Please let me know if you want to be added and share widely on other platforms to get our community here go.bsky.app/SkkmtMG

A statement on the need for scientific rigor in the development of genetic tests, endorsed by @ISPGnet and signed by 140 experts in the field: www.thelancet.com/journals/lan...

Concerns about genetic risk testing for opioid use disorder

In 2023, the US Food and Drug Administration approved the first genetic test for predicting risk of developing a susbstance use disorder.1 The test, which is based on a set of 15 genetic variants, was...

thelancet.com