Congratulations to Alessandro Passera on the completion of his PhD! Passera, a researcher in the Balzarotti lab, presented his dissertation titled “Development of combinatorially-multiplexed DNA-PAINT and application to super-resolved RNA-FISH imaging” during his PhD defense.

Why do pathological protein aggregates persist in cells and how can we overcome this? In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored. #Autophagy #Tau #Proteostasis Out now 👇 www.biorxiv.org/content/10.6...

mRNA is a key polymer of life. While its sequence is linear, its function requires its 3D organization. Yet what does a mRNA look like in 3D? In collaboration with the fbzt.bsky.social, we developed a method to visualize mRNA in 3D and at the nanoscale inside human cells. tinyurl.com/r858t6ff 1/3

I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10

How do you scale super-resolution microscopy to dozens of proteins without linearly scaling imaging time? We introduce Combi-PAINT: a combinatorial DNA-PAINT strategy that breaks the 1-target-per-round bottleneck of Exchange-PAINT: www.biorxiv.org/content/10.6... 1/5