First ERC Synergy meeting with @martenslab.bsky.social and @jimhurley.bsky.social in Vienna, great start! Thanks Sascha for hosting 🙏 @erc.europa.eu

@berndbauer.bsky.social (Martens lab) defended his PhD work "Signed, Sealed, Delivered; I'm Yours Autophagosome: Mechanistic insights into the initiation of aggrephagy" 🎉🎓 - congratulations, well deserved! 💪 @univie.ac.at @meduniwien.ac.at

So excited to share our new paper out today in @nature.com - 'LASER couples damage sensing to ESCRT assembly for lysosome repair'. This was an amazing collaborative effort with Claire Goul during our time in @robzonculab.bsky.social : www.nature.com/articles/s41...

LASER couples damage sensing to ESCRT assembly for lysosome repair - Nature

ATG8 conjugation on damaged lysosomes triggers rapid assembly of a protein complex containing TFG, which directs lysosomal membrane repair by recruiting ESCRT proteins to sites of damage.

nature.com

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇

Our ULK1–MTFR1L paper is now officially in @jcellsci.bsky.social, a good moment to reshare it. 🎉 The work identifies MTFR1L as a key coordinator of mitochondrial fission, mitophagy initiation and apoptosis. 👉 Paper: doi.org/10.1242/jcs....

A ULK1–MTFR1L feedback loop links mitochondrial fission, mitophagy and apoptosis

Summary: MTFR1L acts at mitochondrial mitophagy initiation sites, linking mitochondrial fission with autophagy by interacting with ULK1, regulating ATG13 stability, and forming a feedback loop that su...

doi.org

Why do pathological protein aggregates persist in cells and how can we overcome this? In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored. #Autophagy #Tau #Proteostasis Out now 👇 www.biorxiv.org/content/10.6...

I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10

Big news! Group leader Sascha Martens has been awarded a prestigious @erc.europa.eu Synergy Grant for the collaborative project DegrAbility to explore how cells can better recycle harmful protein aggregates linked to diseases like Alzheimer’s ➡️ tinyurl.com/2zuz9jcf @univie.ac.at @meduniwien.ac.at

A lipid transfer-dependent feedback loop activates ATG9A compartments in autophagy initiation https://www.biorxiv.org/content/10.1101/2025.08.16.670665v1

Absolutely honoured to see our work featured on this month’s cover! 🎉🧬 Artwork by the incredibly talented @doroteaartscience.bsky.social 👇

Nature Cell Biology@natcellbio.nature.com · 12mo ago

🏖️Our August issue's out! Cover: Flexibility of #autophagy initiation 👉🏼Review on #metabolism in #embryogenesis #devbio 👉🏼Review on #DNArepair 🔬 #ribosomes #neurodevelopment #mitophagy #ferroptosis #stemcells #epigenetics #leukemia #antitumor immunity & more! www.nature.com/ncb/volumes/...

WSTF nuclear autophagy regulates chronic but not acute inflammation @nature.com @terjejohansen.bsky.social www.nature.com/articles/s41...

Online Now: Regulation of somatic hypermutation by higher-order chromatin structure Online now:

Regulation of somatic hypermutation by higher-order chromatin structure

Schoeberl et al. employ Tri-C to unravel the higher-order chromatin architecture underpinning the co-transcriptional mutagenesis of immunoglobulin genes during antibody maturation in human B cells. They provide evidence that antibody maturation occurs within a dynamic multiway hub wherein transcription and mutation of different genes occur non-competitively.

dlvr.it

Thanks for selecting me among all the amazing posters at the symposium :D Also congrats to all other winners 👏

SFB Targeted Protein Degradation@sfb-tpd-vienna.bsky.social · last yr.

...AND THE #ubfriends2025 WINNERS ARE 👏 Best Short Talk: @leokiss.bsky.social (@mpibiochem.bsky.social) Best Posters: Irene Schwartz (lab of @versteegga.bsky.social), @julianvangerwen.bsky.social (@imsb-eth.bsky.social), Tom Eisenack (lab @trentini-lab.bsky.social), and @berndbauer.bsky.social!

‪We're excited to announce that registration for the "Tiles of Life" Student Symposium is now open! With a fantastic lineup of guest speakers, complemented by SMICH student talks, we’re set for two inspiring days. Don’t miss out—register now! 🚀🎓✨ #TilesofLife #studentsymposium #SMICH

🚨 Paper Alert! We’re starting off the year with our latest publication in @naturecellbiology.bsky.social on the role of phase separation in selective autophagy initiation! This work was a close and exciting collaboration with @wilflinglab.bsky.social 🔗 nature.com/articles/s41... Here's a thread👇

Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy - Nature Cell Biology

Licheva, Pflaum, Babic, Mancilla et al. show that low-affinity cargo–receptor interactions promote autophagy receptor mobility and condensation of the scaffold protein Atg11 to trigger initiation hub ...

nature.com

🚨 Out now! Bernd Bauer and the Martens lab reveal in EMBO Journal how the cargo receptor TAX1BP1 faciliates the switch from cargo collection to autophagosome formation, a process crucial for successful aggrephagy - the cell's way of recycling aggregated proteins ♻️ More ➡️ tinyurl.com/35ev5pvv

Check out this list of ubiquitin and Ubl profiles to follow. Repost if you want me to add you to it. Let’s create a good community here ☁️ go.bsky.app/3VPQofn