What a spectacular tour de force this lecture was. Thankyou Trish for interesting and entertaining lecture highlighting how personalised medicine and personalised care must be considered together and that technologies are only useful if we retain context around data 1/2

Centre for Personalised Medicine@cpmoxford.bsky.social · 5mo ago

Don’t miss this year’s CPM Annual Lecture! Professor Trish Greenhalgh @trishgreenhalgh.bsky.social will speak on: 'Personalised Medicine: A Primary Care Perspective' 🗓 Tuesday 28th April 2026 📍 Maths Institute, Oxford Find out more and register: cpm.ox.ac.uk/event/cpm-an...

This is such a brilliant and creative entry, I love the concept of people trying to see each other through layers of data

Centre for Personalised Medicine@cpmoxford.bsky.social · 4mo ago

We're delighted to share with you the winner of our 2025-26 Art Competition, which comes from Frida (14), Fallibroome Academy, Macclesfield. The competition explored the meaning of ‘personalised medicine’, with entrants showing us what it means to them 💊🎨🖌️🧬

A huge well done to Nyah! And thank you to everyone who entered and supported the competition this year. You can check out all of the finalists here: cpm.ox.ac.uk/centre-for-p...

Centre for Personalised Medicine Art Competition 2025-26 - cpm

Earlier this year, the CPM ran an art competition asking UK students in Years 7 to 9 (approx. 11 to 14 years old) to send in art exploring the meaning of ‘personalised medicine’ and showing us what it...

cpm.ox.ac.uk

We're pleased to invite you to our 2026 Research Showcase - 'New Frontiers in Personalised Medicine' 🗓️ Wednesday 3rd June 2026 📍 St Anne's College, University of Oxford Find out more and register here: cpm.ox.ac.uk/event/resear...

A huge well done to Ottilie! And thank you to everyone who entered and supported the competition this year. You can check out all of the finalists here: cpm.ox.ac.uk/centre-for-p...

Centre for Personalised Medicine Art Competition 2025-26 - cpm

Earlier this year, the CPM ran an art competition asking UK students in Years 7 to 9 (approx. 11 to 14 years old) to send in art exploring the meaning of ‘personalised medicine’ and showing us what it...

cpm.ox.ac.uk

There needs to be more clarity about what the #NHS10YearPlan offers for patients and what “good enough” looks like in terms of access, along with careful co-design and evaluation of the detail of each of the three shifts. Full paper: ths.im/4b6oPWp THIS Summary: ths.im/49oDU4k

Maybe we should stick to a message this simple.

We’re delighted to announce that Professor Trish Greenhalgh @trishgreenhalgh.bsky.social will deliver this year’s CPM Annual Lecture, 'Personalised Medicine: A Primary Care Perspective' 🗓 28 April 2026 | 📍 Maths Institute, Oxford Find out more and register here: cpm.ox.ac.uk/event/cpm-an...

@emmylooroll.bsky.social said "Gene editing is absolutely a possibility, as is modifying downstream pathways. Genes aren’t all doom & gloom!🧬"

Dylan Williams@dylwil.bsky.social · 7mo ago

1) We've never said "gene edit 95% of the population" Our data speak to scope for intervening on APOE, not nature of intervention or implementation of such When high risk is diffuse in pops, interventions may need to be broad academic.oup.com/ije/article/... But OFC we can consider screening etc

Yes for most of the population it will be modest, looking at the extremes of risk for a population doesnt tell you what the shift in probability would be with intervention for most.

Dylan Williams@dylwil.bsky.social · 7mo ago

2) Approx lifetime risks of AD by 85 years for: e2/e2: perhaps ~2% (clearly well under 5%) e3/e3: ~10% e4/e4: ~60% You think these are "modest shifts in probabilities"?

Gene therapy in ~95% of the population is the naive concept here: manipulating the genomes of most people for only a modest shift in prob. This why, in public discussion, it is more appropriate to talk about genes as modifying risk alongside other factors, not singular “causes” to be edited away.

Dylan Williams@dylwil.bsky.social · 7mo ago

Stressing to public the overlapping roles of both environment and genes is fine...it is naive scientific responses like the one pictured (cited by the Mail) we took issue with. Taking away risk broadly will remove disease (at population level). Tho we could consider gene therapy over magic to do so

yep and as I said, fine in that setting- it was the press release I was responding to-'most alzheimer's cases linked to single gene' we lose the nuance that for 95% population carrying E3/E4, modifiable lifestyle factors remain the dominant lever for prevention.

Emma Anderson@emmylooroll.bsky.social · 7mo ago

1/3: Well, we did write the paper to be published in a scientific (epi) journal… 🤣 And respectfully, that example actually reinforces my point rather than undermines it: having fair skin modifies your risk of sunburn—just like APOE modifies risk of Alzheimer’s. Hence both are causes of disease.

Calling the most common human variant a 'risk allele' is methodologically correct but nosologically problematic—it redefines disease categorisation in a way that obscures rather than clarifies the distinction between genetic susceptibility and modifiable risk pathways.

Neil Davies@neilmdavies.bsky.social · 7mo ago

Therefore, your comments to SMC are simply incorrect. First, our results are not an artefact of choosing a rare protective variant. Using the lowest-risk group is simply the *correct* way to calculate population-attributable fractions. en.wikipedia.org/wiki/Attribu...

🧬 How well do ethnicity labels actually work in genomic medicine? Our new blog explores the challenges - and the pathways to more inclusive, meaningful data. ➡️ cpm.ox.ac.uk/thinking-out... #Genomics #HealthEquity #DiversityInResearch

You can find out more about the competition and enjoy the amazing winning entries from previous years here: cpm.ox.ac.uk/art-and-scie...

Our 2024–25 Annual Report is now live! Reflecting on a year of collaboration, engagement, and impact at the CPM. Explore our flagship events, annual lectures, and creative outreach. ➡️ Read more here: cpm.ox.ac.uk/wp-content/u...

I think we're talking difference between "cause" in epidemiology and what pple understand in everyday speech. IMO "cause" misleads into thinking gene more deterministic than it is. for single dominant risk like smoking, "cause" is fine, but for multifactorial conditions "modifies risk" is better

Emma Anderson@emmylooroll.bsky.social · 7mo ago

’Cause’ doesn’t imply you can eliminate disease, for alleles or any other risk factors. Sticking with the smoking analogy, if we wipe out all smoking tomorrow, some people will still get lung cancer. Smoking is still the biggest cause of lung cancer. I think you’re thinking more about prediction?

I'm really looking forward to this. @CPM we have been fortunate to have absolutely stellar annual lecturers- see here for recordings of the last few years: cpm.ox.ac.uk/series/cpm-a... and @trishgreenhalgh.bsky.social will be no exception

Trish Greenhalgh@trishgreenhalgh.bsky.social · 7mo ago

I'll be giving the Annual Guest Lecture for the Oxford Centre for Personalised Medicine. On 28th April 2026 at 5.30 pm. ‘Personalised Medicine, a Primary Care Perspective’. Open to all. cpm.ox.ac.uk/event/cpm-an...

I'll be giving the Annual Guest Lecture for the Oxford Centre for Personalised Medicine. On 28th April 2026 at 5.30 pm. ‘Personalised Medicine, a Primary Care Perspective’. Open to all. cpm.ox.ac.uk/event/cpm-an...

And 👏 to Honourable exception 🤭

Dylan Williams@dylwil.bsky.social · 7mo ago

My fave commentary on our paper in the Mail last week Interested to know what @alucassen.bsky.social uses as a definition of causation though! Here's mine: ajph.aphapublications.org/doi/full/10.... Further reading WRT the topic: zenodo.org/records/1796...

Thanks for waking me out of bluesky inactivity! Presume this on the back of my SMC quote? My point was that if >95% population have a genotype, it is pretty meaningless to talk about it being causative of disease. Quite happy with apoE alleles *modifying risk* of Alzheimer’s

Dylan Williams@dylwil.bsky.social · 7mo ago

My fave commentary on our paper in the Mail last week Interested to know what @alucassen.bsky.social uses as a definition of causation though! Here's mine: ajph.aphapublications.org/doi/full/10.... Further reading WRT the topic: zenodo.org/records/1796...

Brilliant! I did not know this paper so thanks from infrequent bluesky user for this nugget reposted.

Simon Fisher@profsimonfisher.bsky.social · 9mo ago

With sequencing of Hitler's DNA making headlines, time for a reminder: analysing a polygenic score from a dead historically-significant figure won't give new insights into that person's behaviour. In a brief paper last year, we used Beethoven's genome to directly illustrate the fallacies involved.🧪👇

Have you got a patent application in? Have you been to Sandhill Road in Palo Alto for funding? Why not??? BTW add the strong prediction that the kid will drink milk!

Anneke Lucassen@alucassen.bsky.social · 9mo ago

My test is 99% accurate and predicts that your child will grow to between 5 and 6.5 feet have an IQ between 80 and 130 and live 60-90 years. AND I don’t need any DNA to do my test…

We get the politics the few pay for. #democracy - it would be a good idea www.theguardian.com/politics/202...

Billionaire Tory donor gives £200,000 to Reform UK

JCB chair Lord Bamford hands equal amount to Tories and Reform to support parties he says ‘believe in small business’

theguardian.com

Worried that using ChatGPT harms the planet? A new analysis shows each query uses less energy than a Google search – and far less than lighting a bulb or streaming TV. @eastangliabylines.co.uk

How much energy does ChatGPT really use?

You shouldn’t really worry about your energy use when using domestic AI, it’s probably no worse than watching your favourite soap

eastangliabylines.co.uk

“This thing is definitely bad for us but no one can say what it is”

NPR@npr.org · 9mo ago

The evidence that ultra-processed foods are bad for us is piling up. But efforts to reduce their role in our diets face a big hurdle: experts can't agree on what they are and which to target. n.pr/4qMrN7P

Sounds very appealing: www.theguardian.com/lifeandstyle...

She left her desk job and walked 3,541 miles from Mexico to Canada: ‘Give yourself permission’

Jessica Guo hiked 30 miles a day, becoming the first woman to continuously hike two historic US trails in a calendar year

theguardian.com

#BBCNews - Holocaust survivor and educator Manfred Goldberg dies aged 95 www.bbc.com/news/article...

Holocaust survivor and educator Manfred Goldberg dies aged 95

The German Jewish boy who saw his school closed by the Nazis dedicated his life to educating young people.

bbc.com

A List of Things Said to Have Been Ruined by Women 🧵

Over the last months, we’ve entirely rebuilt search on Our World in Data — we just launched it: ourworldindata.org/introducing-... Let me know what you think. Does it work for you?

Introducing our new, more powerful search

Finding what you’re looking for, or discovering something new, has never been easier.

ourworldindata.org