amelie-iska
@amelie-iska.bsky.social
(She/her) I ❤️proteins! I’m an AI researcher and budding in silico molecular engineer focused mostly on proteins and small molecules. Intersex=awesome 😎🏳️🌈🏳️⚧️⚧️💻🎯🧬🧫🦠🔬⚗️🧪💊💉✡️🪬
Trained a tiny ~17M parameter model for the OpenAI Parameter Golf Bits-per-Byte (BPB) Competition and beat the leading model (BPB<0.57, and the next best model was ~0.74BPB) huggingface.co/AmelieSchrei... huggingface.co/blog/AmelieS... codebase: github.com/amelie-iska/...
GitHub - amelie-iska/ToricGT
Contribute to amelie-iska/ToricGT development by creating an account on GitHub.
github.com
Yes, insurance companies really did cancel fire insurance for Californians 2 months before the LA fires. www.youtube.com/watch?v=5h1H...
California Wildfires Are An Insurance Nightmare
YouTube video by LegalEagle
youtube.com
Did you know that court docs for name and gender changes are not confidential? You can google a trans person’s current name and find their old, dead name — and vice versa. In CA, my amazing bud Hazel is working to fix this, and she may just be successful. My latest for @sfchronicle.com Gift Link 🎁
Changing names puts transgender Californians at risk. New protections could be on the way
A new transgender privacy bill in California would make official name changes confidential.
sfchronicle.com
Pretty amazing that nonprofit Watch Duty -- which says it has 150 volunteers working around the clock to track wildfires -- has become the most trusted source of information on LA fires. Operated by retired/volunteer firefighters, dispatchers, and reporters. Real people. www.watchduty.org
Watch Duty - Wildfire Maps & Alerts
Watch Duty, a 501(c)(3) nonprofit, alerts you of nearby wildfires and firefighting efforts in real-time.
watchduty.org
If you’re in LA, stay safe, leave if you’re told to. Sending good vibes.
As if anyone had any doubt. home.treasury.gov/news/press-r...
Treasury Sanctions Entities in Iran and Russia That Attempted to Interfere in the U.S. 2024 Election
WASHINGTON – Today, the Department of the Treasury’s Office of Foreign Assets Control (OFAC) is designating a subordinate organization of Iran’s Islamic Revolutionary Guard Corps (IRGC), and a Moscow-...
home.treasury.gov
If people find MSA subsampling useful, they will likely find MDGen very useful and they will definitely find BioEmu useful.
UCLA Chem & Biochem is looking for an assistant professor who has "outstanding potential as a scientist, educator, & mentor to students from groups under-represented in the physical sciences". This is part of a cluster hire in physical sciences. @chemjobber.bsky.social recruit.apo.ucla.edu/JPF10039
Physical Sciences HSI Cluster Assistant Professor in Chemistry & Biochemistry
University of California, Los Angeles is hiring. Apply now!
recruit.apo.ucla.edu
Immunotherapy for oncology New more effective & cheap anti-venoms Allosteric switch proteins New Alzheimer’s treatments De novo functional nanopores Vaccines And so much more from Baker Lab. Thank you for being such an inspiration and for forging a path forward. 🚀💜 www.youtube.com/live/HnT1VWz...
YouTube
Share your videos with friends, family, and the world
youtube.com
Thanks! Also check our update to CDR clustering where we modified the D score as max over all dihedral distances including omega, instead of average. Also electron density cutoff to detect peptide flips. Eliminated lots of small CDR clusters with poor density. www.biorxiv.org/content/10.1...
A penultimate classification of canonical antibody CDR conformations
Antibody complementarity determining regions (CDRs) are loops within antibodies responsible for engaging antigens during the immune response and in antibody therapeutics and laboratory reagents. Since...
biorxiv.org
Anthropic needs to get on fine tuning Claude with tree of thought reasoning and GFlowNets.
My apologies to those in love with classical molecular dynamics 😅
Super excited to preprint our work on developing a Biomolecular Emulator (BioEmu): Scalable emulation of protein equilibrium ensembles with generative deep learning from @msftresearch.bsky.social ch AI for Science. www.biorxiv.org/content/10.1...
When my daughter came out to me, she asked if being gay was “natural.” A classmate suggested otherwise… As a professor of animal behavior, I shared 2k+ examples from the animal kingdom! Those became a book, & today it’s still #1 top release and #3 best seller. #LoveWins #WildPride ❤️🏳️🌈 a.co/d/947x66x
Improving structure prediction by padding MSAs with synthetic sequences. Potts model-designed seqs worsen prediction performance, so some higher-order coevolutionary interactions appear to be contributing to this boost openreview.net/pdf/fd516f23...
More evidence that protein folding NNs have learned a crude approximation of an energy function, though the authors here suggest it is at the local level exclusively, because it is only able to make incremental refinements in the absence of coevolutionary data academic.oup.com/bioinformati...
Trying to get Baker Lab's new beta-pairing binder design technique going. Not quite there, but I'm getting close. Anyone have good adj and ss .pt prep code, or a bash script to run the model with on said .pt files?
I like collecting good ideas 😁 there are quite a few floating around in AI4Biochem these days. I love piecing together what has been done in the past 6 months and seeing what is possible in the next 6 months. It just gives me so much hope and excitement to be able to look into the near future. 🚀
