Tessera
Folgen

@andrush05.bsky.social

7 Posts3 Follower6 Folgt
Nazim Kourdougli@nkourdougli.bsky.social · 2w ago

New preprint from the Portera-Cailliau lab! Led by the spectacular Michelle W. Wu. During development, cortical activity becomes higher dimensional. PV interneurons (but not SST) drive this shift, and a new circuit model predicts it. Coupled with RNAseq. So happy to have contributed to this work!

Parvalbumin interneuron maturation reorganizes cortical population activity structure during development

During brain development, spontaneous cortical activity undergoes a dramatic transformation from highly synchronous network events to less correlated and sparse neuronal firing that is thought to unde...

biorxiv.org

Carlos A. Sánchez León@carlosasleon.bsky.social · 2mo ago

PREPRINT 🚨 You know that feeling when you're jamming out to your favorite song (say, La Macarena 💃) and suddenly it skips, or a completely random remix drops out of nowhere? That everyday surprise tells us something profound about how our brain works! 1/24

@andrush05.bsky.social · 2y ago

www.biorxiv.org/content/10.1... Excited to share my postdoctoral work! We mapped how loss of FMRP alters excitatory and inhibitory neurons in Fragile X Syndrome (FXS), the leading monogenic cause of autism. Huge molecular divergence — and a new therapeutic target! 🧵

Translatome profiling reveals opposing alterations in inhibitory and excitatory neurons of Fragile X mice and identifies EPAC2 as a therapeutic target.

Symptoms of Fragile X Syndrome (FXS), the leading monogenic cause of intellectual disability and autism, are thought to arise from an excitation/inhibition (E/I) imbalance. Here, we leverage cell type...

biorxiv.org