Just gave a seminar for the Master in Bioinformatics program at @uam.es sharing our work on ImP in #CVD and new #bioinformaticstools for #metabolomics data. It is always rewarding to share science with future researchers!

“We are closer than ever to the day when a diagnosis of Alzheimer’s disease stops being a death sentence — but only if we continue to support researchers and enable their ability to work with one another,” writes Bill Gates in a World View article for Nature Medicine. #medsky 🧪

Global collaboration is key to decoding Alzheimer’s disease

Recent progress on Alzheimer’s disease shows what we gain when scientists work together — and what the world loses when bad policies force them apart.

go.nature.com

Fantástico resumen por @manuelansede.bsky.social 🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón € 🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab 🙏 @erc.europa.eu ERC-CoG ERC-POC #CNIC_CARDIO Open acess: www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

nature.com

Manuel Ansede@manuelansede.bsky.social · last yr.

Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @sancholab.bsky.social, se acaba de publicar en la revista @nature.com 👇 elpais.com/salud-y-bien...

A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment|ERC erc.europa.eu/news-events/...

A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment

A new study led by the Spanish National Centre for Cardiovascular Research (CNIC) and funded by the European Reasearch Council (ERC) has identified imidazole propionate (ImP), a metabolite produced by...

erc.europa.eu

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

nature.com

Esta investigación del CNIC revela que un metabolito de la microbiota intestinal favorece la aterosclerosis. Descubre más de la mano de uno de los investigadores del equipo 👇🧬

David Sancho@sancholab.bsky.social · last yr.

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

🌟Proud to share our latest research: "Imidazole propionate (ImP) is a driver therapeutic target in atherosclerosis" in @nature.com A step toward early diagnosis & targeted therapy in cardiovascular care! #metabolites #impact #PersonalizedMedicine 👇🧵https://www.nature.com/articles/s41586-025-09263-w

Have you missed #MetSoc25? Join us for our Munich Metabolomics Meeting. We still have open seats and talk slots! Be fast, they will be taken soonish 😜 Register and submit your abstract under www.munichmetabolomics.com #metabolomics #lipidomics

Michael Witting@metabomichael.bsky.social · last yr.

#ASMS2025 is around the corner, #MetSoc2025 is coming up soon... And if you don't have enough or you might missing out on these two, please consider this year's Munich Metabolomics Meeting. Registration is now open. We have @pluskal-lab.org as wonderful keynote speaker www.munichmetabolomics.com

Since 1869, Nature's journal has been delivering some of the coolest science out there. Big thanks to the editor George Caputa for sharing a behind-the-scenes look super insightful and inspiring! 🧠🔬🌍 #NatureJournal #BehindTheScenes

There so much to learn what microbes are doing inside us. Glad to be part of this work, thanks to Pieter and the whole team.

Pieter Dorrestein@pieterdorrestein.bsky.social · last yr.

If you have ever wondered what might happen to short chain fatty acids made by the microbiome. Here is a large class of metabolites and how they link to biology. www.cell.com/cell/fulltex...

This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions www.cell.com/cell/abstrac...

Cross-organ metabolite production and consumption in healthy and atherogenic conditions

An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...

cell.com

A pen loaded with magnetic ink can be used to help detect early onset Parkinson’s disease, suggests a study in Nature Chemical Engineering. Neural network assisted data analysis in the device can identify differences in the handwriting of people with and without the disease. #medsky 🧪

Neural network-assisted personalized handwriting analysis for Parkinson's disease diagnostics - Nature Chemical Engineering

This study presents a diagnostic pen with ferrofluid ink that converts handwriting into sensing signals for Parkinson's disease (PD) diagnostics. In pilot studies, neural network-assisted analysis of collected handwriting signals accurately distinguished patients with PD, demonstrating the pen's potential as a low-cost, scalable tool for accessible diagnostics.

go.nature.com

Here is the exciting original publication: www.nature.com/articles/s41...

Activation of lysosomal iron triggers ferroptosis in cancer - Nature

Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

nature.com

Check out ADAPT-MS: our flexible, scalable diagnostic framework that transforms discovery plasma proteomics directly into clinical decisions.Dynamic retraining enables single-sample diagnostics for any clinical question. www.medrxiv.org/content/10.1...

Glad to share our latest paper on optical biosensors for diagnosing neurodegenerative diseases: www.nature.com/articles/s44... @natureportfolio.nature.com @uazbio5.bsky.social

Optical biosensors for diagnosing neurodegenerative diseases - npj Biosensing

npj Biosensing - Optical biosensors for diagnosing neurodegenerative diseases

nature.com

A study in Nature Immunology uses a model of lipopolysaccharide injection in humans to characterize the transcriptomic landscape of bone marrow and blood immune cells during the hyperinflammatory and immunosuppressed phases of systemic inflammation. go.nature.com/44bj71Y

New @science.org Exposomics. We're not doing nearly enough to understand and mitigate our toxic environmental exposures. A very insightful perspective www.science.org/doi/10.1126/...

A Review in Nature Medicine summarizes recent and compelling examples of microbiome-based interventions that are ripe for clinical adoption while also discussing the challenges and opportunities facing the field. go.nature.com/42LUmrU 🔒

Great talk by @sancholab.bsky.social shedding light on the role of #dendriticcells in #atherosclerosis: players in shaping immune responses within plaques. #ImmunoAthero

Insightful talk by Maria Mittelbrunn: T cells are key drivers of aging! Dysfunctional T cells trigger inflammaging, accelerating tissue senescence and age-related diseases. Today at the #ImmunoAthero meeting #TCellAging #Inflammaging

Interestingly, both subclinical #hypothyroidism and #thyrotoxicosis predict #MACE. The free thyroxine (FT4) concentration is more associated with the HR for cardiovascular events than thyrotropin (TSH) levels. Our observations yield an integrated model including psychosocial and somatic mechanisms.

#Thyroid hormones profoundly impact the #cardiovascular system. They act at all levels, ranging from the tier of ion currents over cellular processes to the macroscopic levels of myocardial tissue and even the whole organism. 🧪 🩺 #MedSky doi.org/10.3389/fcvm... pubmed.ncbi.nlm.nih.gov/36046184/

Met-ID: An Open-Source Software for Comprehensive Annotation of Multiple On-Tissue Chemical Modifications in MALDI-MSI #AC pubs.acs.org/doi/10.1021/...

Met-ID: An Open-Source Software for Comprehensive Annotation of Multiple On-Tissue Chemical Modifications in MALDI-MSI

Here, we introduce Met-ID, a graphical user interface software designed to efficiently identify metabolites from MALDI-MSI data sets. Met-ID enables annotation of m/z features from any type of MALDI-M...

pubs.acs.org

Put a dendritic cell (DC) in your tumor #immunotherapy! cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! #CNIC @ageinves.bsky.social @contracancerinv.bsky.social www.nature.com/articles/s41... #immunosky #cancersky (1/7)

Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications

Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...

nature.com

Couldn’t be said better: Avoid misusing pathway analysis in #metabolomics! A must-read for anyone working with metabolomics data. #bioinformatics www.nature.com/articles/s42...

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism

Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

nature.com

Una encuesta super interessante sobre la #perception de la realidad en el entorno de trabajo para #cientificos y #cientificas del area #STEMM. 👩🏼‍🔬👨🏻‍🔬 Descubre si lo que crees es realmente tu percepción! 😏😏Aqui el enlace: lnkd.in/d2-A92Y8

Gigantic birth study paints most detailed picture of pregnancy’s toll on body Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby. www.nature.com/artic... 1/3

Gigantic birth study paints most detailed picture of pregnancy’s toll on body

Nature - Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

nature.com

There is still time to apply for the Q2 empowerment award! 🏆

Females in Mass Spectrometry (FeMS+)@femalesinms.bsky.social · 2y ago

Applications are open for the #FeMS+ 2025 Q2 Empowerment Awards! Thanks @brukercorporation.bsky.social for sponsoring! Apply here: airtable.com/appyGufCIumj... #TeamMAssSpec #WomenEmpowerment

FeMS empowerment awards are now open! Please RT 😊 #femalesinMS @femalesinms.bsky.social

Females in Mass Spectrometry (FeMS+)@femalesinms.bsky.social · 2y ago

Applications are open for the #FeMS+ 2025 Q2 Empowerment Awards! Thanks @brukercorporation.bsky.social for sponsoring! Apply here: airtable.com/appyGufCIumj... #TeamMAssSpec #WomenEmpowerment

Ha sido un placer compartir espacio con mis compañeras para ayudar a entender mejor el trabajo de una #científica y nuestra #pasión por lo que hacemos. Espero que nuestras palabras inspiren a los jóvenes a seguir sus pasiones y tomar decisiones informadas sobre su futuro. 👩‍🔬 #CarrerasSTEM #Educación