Un estudio liderado por el investigador de nuestra red @sancholab.bsky.social (CNIC) publicado en Science Immunology identifica un “checkpoint” mitocondrial que regula la activación de células dendríticas y su capacidad para activar linfocitos T contra virus y tumores.

Science Immunology: Mitochondria control immune cell activation and the effectiveness of immunotherapy

tinyurl.com

Fresh from science immunology, the @sancholab.bsky.social group identifies " the mitochondrial redox metabolism as a key regulator of antigen cross-presentation in conventional type 1 DCs" 👏 and 👇 www.science.org/doi/10.1126/...

Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells

Mitochondrial complex I dysfunction in dendritic cells disrupts NAD+/NADH redox balance and impairs antigen cross-presentation.

science.org

Congrats to the @sancholab.bsky.social et al, for this nice paper in @natcomms.nature.com showing that "type 1 conventional dendritic cell-based vaccination excels at immune memory induction and prevention of cancer recurrence" www.nature.com/articles/s41...

Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications

Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...

nature.com

How does oxygen sensing shape #alveolar #macrophage (AM) identity? Our new @cp-cellreports.bsky.social: HIF-1α and HIF-2α play distinct, non-redundant roles in AM maturation & function A #metabolic split that defines macrophage biology in the lung. 🔗 doi.org/10.1016/j.ce... #CNIC #immunosky

HIF-1α and HIF-2α differentially regulate alveolar macrophage maturation and function @cp-cellreports.bsky.social www.cell.com/cell-reports... @sancholab.bsky.social

Does mitochondrial respiration in DCs just “fuel” activation? In our new @ScienceImmunology study, we show that #mitochondrial Complex I is a selective checkpoint for #antigen #cross-presentation in #DCs, especially #cDC1s www.science.org/doi/10.1126/... At: CNIC_CARDIO @inmunosky

Mitochondrial complex I dysfunction in dendritic cells disrupts NAD+/NADH redox balance and impairs antigen cross-presentation @sciimmunology.bsky.social @sancholab.bsky.social www.science.org/doi/10.1126/...

Wonderful work, David! The concept that ETC flux—not ATP—licenses cDC1 immunogenicity through /metabolite control of DNA methylation is conceptually beautiful. Congrats to Ignacio, Stefanie and the whole team! Thanks for giving us the chance to learn throught this collaboration!

David Sancho@sancholab.bsky.social · 4mo ago

🤔Do you think that OXPHOS in DCs = tolerance? In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance. Life (& #immunometabolism) is not simple ⚡️ OPEN: www.cell.com/cell-metabol... #immunoSky

🤔Do you think that OXPHOS in DCs = tolerance? In our new @cp-cellmetabolism.bsky.social #cnic_cardio & @irbbarcelona.org, we show that active #mitochondrial ETC primes cDC1s for immunogenicity, not tolerance. Life (& #immunometabolism) is not simple ⚡️ OPEN: www.cell.com/cell-metabol... #immunoSky

Always a mind-blowing talk from @sancholab.bsky.social who showed, alongside cool data on macs, that cIII inhibition in cDC1 has functional consequence on anti-tumor immunity > mitochondrial ETC disruption impact on histone demethylase and alter PU.1 pioneer activity. Everything linked !

#WeekendRead! #InterferonPower! Dunphy @sancholab.bsky.social &co show @cp-immunity.bsky.social that in #macrophages, STING leads to type I #IFNs & ISG15-dependent ISGlatyion of mitochondrial proteins, increasing efferocytosis & driving epigenetic remodeling thus supporting inflammation resolution!

A type I interferon-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages

Macrophage metabolism is intricately linked to cellular function. Contrasting with Toll-like receptor (TLR) stimulation, cytosolic nucleic acid sensin…

sciencedirect.com

#PhD in #immunometabolism on fatty acid oxidation in #macrophage function. MSCA-DN: unimedizin-mainz.de/unlimited-ms... For our DC8 position apply in parallel in 2 sites: 1. unimedizin-mainz.de/unlimited-ms... 2. cnic.es/en/convocato... (DC8: NOT resident in Spain >12m in last 3 years) #immunosky

Great opportunity for a #PhD on how lipid #metabolism regulates immune cell function in diseases such as cancer and autoimmunity. Train in immunology, bioIT, & metabolism. Apply in parallel in: 1. UNLIMITED: www.unimedizin-mainz.de/unlimited-ms... 2. Local partner site that you choose. #immunosky

Excessive #inflammation? We uncover @cp-immunity.bsky.social that #IFN-I via #ISG15 in macrophages lowers #mitochondrial membrane potential, boosts #efferocytosis, and self limits #ISG amplification: a built in brake that promotes resolution. Open-access: www.cell.com/immunity/ful... #immunosky

A type I IFN-mitochondrial axis regulates efferocytosis and interferon-stimulated gene induction in macrophages @cp-immunity.bsky.social @sancholab.bsky.social www.cell.com/immunity/ful...

Don't miss the 2nd Conference of the European ImmunoMetabolism Network - EIMN2026 📅10-12th June 2026 📌Luxembourg immunometnet.eu @immunometeurope.bsky.social linkedin.comevents/2ndconferenc...

7/ 🔬 What researcher @sancholab.bsky.social (CNIC) sees as an advance to improve cardiovascular health, artist and #laCaixaFoundFellows @guillermomora.bsky.social sees as a moving map. 🎨 They explain it to us in this #SnapshotsOfTheMonth. 👇 https://bit.ly/3XMZfOc

I had the pleasure of acting as an external PhD examiner for @aitorjarit.bsky.social in the lab of @sancholab.bsky.social 🇪🇸 during the summer. Today I received his PhD thesis and a beautiful gift of a mitochondria illustrated in the style of an Andalusian tile. Thank you very much!

🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism. www.embopress.org/doi/full/10.... (1/9)

Homeostatic control of energy metabolism by monocyte-derived macrophages | The EMBO Journal

imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital parameters within physiological ranges. This study characterizes how mouse monocyte-derived macrophages...

embopress.org

🌞 Day 2 begins at La Cristalera! Today we welcome 2 Invited Plenary Speakers: 🔶 Prof. David Sancho, @sancholab.bsky.social (CNIC) 🔶 Prof. Susana Guerrero Salazar (University of Málaga) ✨Another full day of science, ideas, and inspiring talks ahead! #RetreatIIBM_2025 #IIBmCSICUAM @csic.es @uam.es

Gracias @caixaresearch.bsky.social por el sólido apoyo a nuestra investigación. Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/... También apoyo fundamental en: www.nature.com/articles/s41...

cDC1s Promote Atherosclerosis via Local Immunity and Are Targetable for Therapy | Circulation Research

BACKGROUND: Atherosclerosis is characterized by immune cell accumulation in the arterial wall and adaptive CD4+ T helper 1 immunity contributes to atherosclerosis development. However, how conventiona...

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@caixaresearch.bsky.social · last yr.

1/ 🔬🖼️ Cuando ciencia y arte se sientan a mirar lo mismo, aparecen nuevas formas de entender la realidad. Lo descubrimos en esta #InstantáneasCaixaResearch con el investigador @sancholab.bsky.social y el becario de la Fundación “la Caixa” y artista Guillermo Mora.🧵👇 https://tinyurl.com/3yjke2z9

This work identifies 'imidazole propionate' as a causal microbial metabolite that promotes atherosclerosis and shows that modulating its levels can potentially prevent cardiovascular disease risk, a promising therapeutic strategy.👇

David Sancho@sancholab.bsky.social · last yr.

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment|ERC erc.europa.eu/news-events/...

A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment

A new study led by the Spanish National Centre for Cardiovascular Research (CNIC) and funded by the European Reasearch Council (ERC) has identified imidazole propionate (ImP), a metabolite produced by...

erc.europa.eu

Fantástico resumen por @manuelansede.bsky.social 🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón € 🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab 🙏 @erc.europa.eu ERC-CoG ERC-POC #CNIC_CARDIO Open acess: www.nature.com/articles/s41...

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

nature.com

Manuel Ansede@manuelansede.bsky.social · last yr.

Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @sancholab.bsky.social, se acaba de publicar en la revista @nature.com 👇 elpais.com/salud-y-bien...

Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @sancholab.bsky.social, se acaba de publicar en la revista @nature.com 👇 elpais.com/salud-y-bien...

Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes

El descubrimiento, gracias a un experimento con cientos de trabajadores del Banco Santander en Madrid, abre la puerta a nuevos tratamientos más allá de reducir el colesterol

elpais.com

Esta investigación del CNIC revela que un metabolito de la microbiota intestinal favorece la aterosclerosis. Descubre más de la mano de uno de los investigadores del equipo 👇🧬

David Sancho@sancholab.bsky.social · last yr.

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

💥 A gut microbe metabolite that drives #atherosclerosis? Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol. 🧪 We show the pathway—and how to block it. nature.com/articles/s41... #OpenAccess at @Nature @CNIC_CARDIO #CVD #immunosky #cardiosky #microbiomesky

Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...

nature.com

Thank you to my co-author @iroblesv.bsky.social and @sancholab.bsky.social for believing in this project and to all the researchers who contributed to this work!!

Congrats @iannaconelab.bsky.social & team on a wonderful work @natimmunol.nature.com on the immune regulation in the liver: CD4+ T cells license Kupffer cells to rescue CD8+ T cells through IL12 & mainly IL27. Highly relevant for liver immunotherapy!!! 👏🏻👏🏻👏🏻👏🏻👏🏻 #immunosky 👇🏻👇🏻👇🏻

Iannacone Lab@iannaconelab.bsky.social · last yr.

1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)

🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles. 🔗 doi.org/10.1161/CIRC... #Immunotherapy #Atherosclerosis #Nanomedicine #CNIC_CARDIO #immunosky #cardiosky