David Negus
@davidnegus.bsky.social
Microbiologist, lover of phage and predatory bacteria. Senior lecturer at Nottingham Trent University. Department of prokaryotes culturable.
Join us for the Biotic Control of Bacteria meeting in Nottingham on 8 September 2026. Connect with researchers and dive into the latest findings on bacterial antagonism, predatory microbes and more. Don't miss out, register by 8 August: https://microb.io/4w3BQHG. #Microbiology
🎉 New preprint. First piece of work from us looking at how Klebsiella spp. use gut microbiome-associated metabolites present in urine. Very much v1 but we wanted it out for feedback, and to support lead author @devarsh1917.bsky.social as he applies for PhDs. #microSky
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 3mo agoHippurate hydrolases encoded by Klebsiella pneumoniae and Klebsiella oxytoca are functional https://www.biorxiv.org/content/10.64898/2026.07.27.739834v1
Working on phage, predatory bacteria, bacterial antagonism, microbial warfare or microbiome manipulation? we've got the conference for you! Join us at the Microbiology Society Biotic Control of Bacteria meeting in Nottingham September 8th 2026. Details here: microbiologysociety.org/event//bioti...
Biotic Control of Bacteria
microbiologysociety.org
🚨 Calling all microbial genomics & metagenomics researchers 🚨 Join us in Nottingham, 5 June for a day of talks, posters & FREE networking lunch 👀 🎤 Keynotes @halllab.bsky.social @alexmsalmeida.bsky.social 🤝 with @bugsinyourguts.bsky.social & Microbiome-Net 🔗 linktr.ee/microbesng#MicroSky #MNGPopUp
🚨 New Research Alert! Our team has discovered two new bacteriophages that target Serratia spp.—a major cause of hospital‑associated infections and a growing antibiotic‑resistance threat. 📄 Open‑access article in Journal of Applied Microbiology: doi.org/10.1093/jambio/lxag011
Characterization of two novel bacteriophages infecting clinical isolates of Serratia spp. and therapeutic efficacy in a Galleria mellonella model of infection
AbstractAims. This study aimed to isolate virulent bacteriophages (phages) with the capacity to lyse clinical strains belonging to the genus Serratia. Furt
doi.org
🧬 Free @microbesng.bsky.social PopUp ECR symposium 🧬 UK-based MRes or PhD student, research assistant or postdoc working on microbial genomics or metagenomics? Present your work and/or chair a session, plus excellent keynote speakers: @halllab.bsky.social and @alexmsalmeida.bsky.social. #MNGPopUp
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8
Delighted for @mohamedeladawy.bsky.social on the publication of the "big one" from his PhD work. - Largest genome-based study on uropathogens in Egypt. - AMR genes for Pseudomonas, and those associated with meropenem poorly understood. - Prediction databases need better curation. #UTIsky #microsky
Phenotype–genotype discordance in antimicrobial resistance profiles of Gram-negative uropathogens recovered from catheter-associated urinary tract infections in Egypt
AbstractObjectives. Catheter-associated urinary tract infections (CAUTIs) are among the most common healthcare-associated infections in low- and middle-inc
academic.oup.com
If you are UK-based and working on any aspect of microbiomes (human, plant, insect, soil, animal, ...), please do sign up to Microbiome-Net for details of networking, funding and training opportunities. forms.office.com/pages/respon...
Microsoft Forms
forms.office.com
Professor Lesley Hoyles@bugsinyourguts.bsky.social · last yr.Delighted to announce the launch of the BBSRC-funded UK-wide microbiome innovation network Microbiome-Net. I'm looking forward to representing and furthering the East Midlands Microbiome Research Network's contributions to research, innovation and policy. www.liverpool.ac.uk/microbiome-i...
You have to love Belgium. A country built on beers, bikes and bacteriophage.
We have a position for an Assist Prof in Microbial Genomics in our School of III. Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it www.jobs.ac.uk/job/DOO184/a...
Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham
Apply now for the Assistant Professor (Research and Education) in Bacterial Genomics role on jobs.ac.uk - the leading job board for higher education jobs. View details.
jobs.ac.uk
Interested in investigating the use of bacteriocins for the treatment of urinary tract infections? Come work with me and @bugsinyourguts.bsky.social Professor Lesley Hoyles as a research associate on an exciting project funded by The Urology Foundation vacancies.ntu.ac.uk/Job/JobDetai...
Research Associate:Clifton Campus
vacancies.ntu.ac.uk
I'm super happy to share this preprint on ‘Distribution of capsule and O types in #Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage’ doi.org/10.1101/2025...
Distribution of capsule and O types in Klebsiella pneumoniae causing neonatal sepsis in Africa and South Asia: meta-analysis of genome-predicted serotype prevalence and potential vaccine coverage
Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against 70% of K. pneumoniae infections, could aver...
doi.org
Great to see the typeset version of this invited review out. Covers pretty much everything we know about metabolites/peptides produced by Klebsiella spp. and how they interact with the host. #microsky #microbiomesky @microbiotaandhost.bsky.social doi.org/10.1530/MAH-...
Host interactions of bioactive molecules produced by Klebsiella spp
Abstract Klebsiella spp. are early colonisers and commensals of human skin, oral, nasal, throat and gut microbiotas, but are also opportunistic pathogens. Much of our information on these bacteria is ...
doi.org
🚨New publication🚨 We show that K. Pneumoniae bacteriophages can be incorporated into alginate to create an antibiofilm matrix effective against clinical K. pneumoniae strains academic.oup.com/jambio/artic...
Bacteriophage-embedded and coated alginate layers inhibit biofilm formation by clinical strains of Klebsiella pneumoniae
AbstractAims. This study aimed to determine the antibiofilm properties of Klebsiella pneumoniae phages previously isolated from Thai hospital sewage water.
academic.oup.com
Very pleased to see this review out on host interactions of bioactive molecules produced by Klebsiella spp. #MicroSky
mah.bioscientifica.com
New preprint from @mohamedeladawy.bsky.social This represents the main body of work from Mohamed's thesis. He's carried out the largest study, to date, on G-ve (11 different genera) CAUTI-associated bacteria in Egypt. #UTIsky #Microsky #AMR It's been a pleasure to supervise Mohamed's PhD studies.
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2y agoPhenotype-genotype discordance in antimicrobial resistance profiles of Gram-negative uropathogens recovered from catheter-associated urinary tract infections in Egypt https://www.biorxiv.org/content/10.1101/2025.04.17.649370v1
New paper from me and @davidnegus.bsky.social. We've trebled the number of authenticated webervirus genomes, and show that low-quality virome MAGs are to be avoided in comparative analyses. academic.oup.com/femsec/advan...
Weberviruses are gut-associated phages that infect Klebsiella spp.
Abstract. Weberviruses are bacteriophages (phages) that can infect and lyse clinically relevant, multidrug-resistant (MDR) strains of Klebsiella. They are
academic.oup.com
Two ERC-funded postdoc positions available in the team - one here and second to follow - please repost! jobs.ncl.ac.uk/job/Newcastl...
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
Research Associate Genetic and functional analysis of Gram positive secretion systems and substrates
jobs.ncl.ac.uk
Congratulations to Caitlin Wildsmith on the second paper from her PhD with @davidnegus.bsky.social! #microsky
Genomic and phenotypic characterization of staphylococci isolated from the skin of non-human primates
The growth of wildlife tourism coupled with continued deforestation has resulted in increased contact between non-human primates (NHPs) and humans. Such events may promote the transmission of potentia...
microbiologyresearch.org
We had a few weberviruses isolated and lots of K. pneumoniae strains/genomes but hadn't done anything with them. COVID lockdown meant Sam needed to change the focus of his PhD for a while. This is the result. Nice collaboration with @davidnegus.bsky.social and @halllab.bsky.social, among others.
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 2y agoWeberviruses are gut-associated phages that infect Klebsiella spp. https://www.biorxiv.org/content/10.1101/2024.11.04.620279v1
New paper alert! New paper alert! Insight, including genomic analyses, in to Staphylococcal diversity on NHP skin. @microbiologysociety.org @davidnegus.bsky.social www.microbiologyresearch.org/content/jour...
Genomic and phenotypic characterization of staphylococci isolated from the skin of non-human primates
The growth of wildlife tourism coupled with continued deforestation has resulted in increased contact between non-human primates (NHPs) and humans. Such events may promote the transmission of potentia...
microbiologyresearch.org