Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness. We found that transposable elements sustain stem-like states in AML and predict patient outcomes. www.nature.com/articles/s41...

Alterations of chromatin state at transposable elements rewire stemness in acute myeloid leukemia - Nature Genetics

By mapping chromatin accessibility over transposable elements (TEs) across normal hematopoietic cells and the various cell types of primary acute myeloid leukemia (AML), we identified TE subfamilies w...

nature.com

1/ My PhD work is finally out in @natgenet.nature.com ! 🎉 We introduce SelectSim and map co-mutations across >70,000 tumors and 100+ cancer types and subtypes. Cancer mutations do not act in isolation; their combinations can shape tumor evolution. www.nature.com/articles/s41...

Evolving patterns of co-mutations from tumor initiation to metastatic progression - Nature Genetics

SelectSim uses cancer and healthy tissue sequencing datasets to identify co-mutations that occur more or less frequently than would be expected by chance. Differences in co-mutation patterns observed ...

nature.com

The home has its own kind of peace. Not the kind that stops work, but the kind that slows the noise enough for you to see life a little more clearly. #break #peace #life #randomthoughts

Evolution is magnificent, but if humanity is its highest achievement, then perhaps the measure of greatness is flawed, shaped by the same pretension with which humans crown themselves. #random #thought #science #rambling

Went to a genaigenesis.ca hackathon after 8 years 🤖 Felt old. Felt lost. Built anyway. And somewhere in between the code, coffee, and chaos.. I remembered why I started building in the first place 💭 Wrote about this experience here: 👉 arvindkiyer.com/mixomania/20... #AI #Hackathon #Learning #GenAI

Another work from lab @matlupien.bsky.social #science #research #cellfreeDNA #earlydetection

Nature Cancer@natcancer.nature.com · 6mo ago

🌟New Resource article Read about the pancancer landscape of cancer-specific cell-free DNA methylation and fragmentomic features from plasma samples from 1,294 patients ✒️Yong Zeng, @matlupien.bsky.social, @pughlab.bsky.social, Housheng Hansen He & colleagues www.nature.com/articles/s43...

Check out this work from our lab @matlupien.bsky.social #science #research #cancer #prostate

Mathieu Lupien@matlupien.bsky.social · 8mo ago

Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.

Is science selfish? A 3 AM thought... arvindkiyer.com/mixomania/20... #random #life #science #Philosophy #PhD

Finally sharing Part 1 of my PCA series!-discover the history behind one of the most fundamental tools in stats & computational biology. Dive in: arvindkiyer.com/mixomania/20... #PCA #Statistics #ComputationalBiology #DataScience #BioCodeTalks #Blog #Writing #Science

My lab is recruiting postdocs in AI/ML for genetics & genomics through the Malone Postdoctoral Fellows program. Apply by Jan 30! Lots of other great labs across the Malone Center as well.

JHU Malone Center for Engineering in Healthcare@jhumceh.bsky.social · 8mo ago

Looking for a postdoc opportunity in computational & engineering applications in medicine & health care? Apply to the Malone Fellows Program and work with mentors in genomics, AI/data science, robotics, human-computer interaction, augmented/virtual reality, & more. Deadline coming up: Jan 31, 2025

After a PhD burnout, I decided to make health and discipline my priority. Discipline > motivation.. 💪 Slow progress compounds quietly 📈 . My 2025 weight loss journey so far.. Read the full story arvindkiyer.com/mixomania/20... #HealthyHabits #selfimprovement

Happy moment... My mentor Prof Debarka Sengupta got one of the highest Indian national science awards today. 🥳🥳❤️❤️... A well deserved. #proud #happy #mentor #science

After a long spell of procrastination, I’ve finally re-started something close to my heart "Mixomania". It’s a space where I’ll be sharing a mix of poems, deep dives into science aka computational biology and cancer genomics, and the occasional personal ramble or neural musing.

Let's check out this app. Looking to connect to people to talk about #science #research #curiosity