Mathieu Lupien
@matlupien.bsky.social
Senior scientist @Princess Margaret Cancer Centre, Prof @UofT. BHAG: Conquer cancer by treating it as a disease of the chromatin. https://lupienlab.uhnresearch.ca/
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
A new study by @uhn.ca Princess Margaret Cancer Centre and University of Oxford identified a subset of blood stem cells that are shaped by past inflammatory events. These cells can accumulate with age and are linked to mutations with a higher risk of leukemia. www.nature.com/articles/s41...
Upcoming cancer epigenetics conference in Paris (Oct 13-16, 2026). Consider registering: www.atoutcom.com/cancer-epige...
Cancer Epigenetics
atoutcom.com
Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome. Grateful to the team & collaborators. www.nature.com/articles/s41...
Transposable elements shape stemness in normal and leukemic hematopoiesis - Nature Genetics
This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...
nature.com
Excited to share our Nature Genetics Research Briefing on how the repetitive genome helps shape leukemia stemness. We found that transposable elements sustain stem-like states in AML and predict patient outcomes. www.nature.com/articles/s41...
Alterations of chromatin state at transposable elements rewire stemness in acute myeloid leukemia - Nature Genetics
By mapping chromatin accessibility over transposable elements (TEs) across normal hematopoietic cells and the various cell types of primary acute myeloid leukemia (AML), we identified TE subfamilies w...
nature.com
Excited to share our @natgenet.nature.com study showing that epigenetically rewired transposable elements control AML leukemia stem cell properties and patient outcome. Grateful to the team & collaborators. www.nature.com/articles/s41...
Transposable elements shape stemness in normal and leukemic hematopoiesis - Nature Genetics
This study identifies distinct transposable element subfamilies as genetic determinants of stemness properties in normal and leukemic stem populations with clinical implications for patients with acut...
nature.com
Our new study found that ancient DNA sequences in our genome, called transposable elements, can act as control hubs for leukemia stem cells, fueling therapy resistance and relapse in AML. Led by @matlupien.bsky.social & John Dick @uhn.ca @uhnresearch.ca. www.nature.com/articles/s41...
The first astronaut in history to speak French while en route to the moon — Canada’s very own Jeremy Hansen 🇨🇦
Our most recent work on the “function and evolution” of #nuclear-speckles is now online at Cell @cp-cell.bsky.social doi.org/10.1016/j.ce... Read the thread👇 for the highlights of our findings.
Redirecting
doi.org
We're excited to announced that our 2nd Annual QMUL Centre for Epigenetics Conference is happening on June 18th, 2026 at Mile End! To find out more and book your ticket, please follow this link: www.qmul.ac.uk/epigenetics/... The deadline to book your tickets is Monday, June 8th 2026.
Pleased to share our new @natcancer.nature.com paper, where we harmonized cfMeDIP-seq across 11 cancer types, integrating methylation & fragmentation to boost detection. This resource strengthens the foundation for liquid biopsy monitoring to enable better, earlier, less invasive care.
A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer
Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...
nature.com
🌟New Resource article Read about the pancancer landscape of cancer-specific cell-free DNA methylation and fragmentomic features from plasma samples from 1,294 patients ✒️Yong Zeng, @matlupien.bsky.social, @pughlab.bsky.social, Housheng Hansen He & colleagues www.nature.com/articles/s43...
A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer
Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...
nature.com
Our researchers analyzed 1,294 blood samples from 11 cancer types to build a comprehensive atlas of DNA methylation patterns, advancing pan-cancer detection and monitoring through liquid biopsy. Published in Nature Cancer: www.nature.com/articles/s43... @uhnresearch.ca @uhn.ca
Mathieu Lupien@matlupien.bsky.social · 6mo agoMassive team-science effort across @pmresearch-uhn.bsky.social @uhnresearch.ca @uhn.ca @oicr.on.ca and collaborators (incl. TrevorPugh & Hansen He labs; lead author Yong Zeng). www.nature.com/articles/s43...
Pleased to share our new @natcancer.nature.com paper, where we harmonized cfMeDIP-seq across 11 cancer types, integrating methylation & fragmentation to boost detection. This resource strengthens the foundation for liquid biopsy monitoring to enable better, earlier, less invasive care.
A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection - Nature Cancer
Zeng et al. analyzed cfDNA methylation and fragmentomic data from 1,294 patient plasma samples across 14 major cancer types to present a comprehensive landscape of pancancer and cancer-specific cell-f...
nature.com
New study from Dr. Hansen Housheng He’s team, thrilled that we contributed, on functional mapping of m6A in cancer at scale with implications for novel target discovery and future therapeutic development. www.nature.com/articles/s43...
METTL3-based epitranscriptomic editing screening identifies functional m6A sites in cancers - Nature Cancer
He and colleagues develop a METTL3-based RNA base-editing screening strategy to identify functional N6-methyladenosine (m6A) sites that are important for prostate cancer cells and validate the role of...
nature.com
New study from Dr. Hansen Housheng He’s team, thrilled that we contributed, on functional mapping of m6A in cancer at scale with implications for novel target discovery and future therapeutic development. www.nature.com/articles/s43...
METTL3-based epitranscriptomic editing screening identifies functional m6A sites in cancers - Nature Cancer
He and colleagues develop a METTL3-based RNA base-editing screening strategy to identify functional N6-methyladenosine (m6A) sites that are important for prostate cancer cells and validate the role of...
nature.com
Our new study found that, when prostate cancer cells spread, they adopt an “inflammatory-like” state and mimic immune cells, suggesting new ways to control cancer progression. Co-led by @matlupien.bsky.social @uhn.ca @uhnresearch.ca with @dkfz.bsky.social: doi.org/10.1038/s414...
Back-to-back: Integrating single-nuclei RNA-seq and whole-genome sequencing, @joachimwei.bsky.social and his team show how prostate cancer metastasis is shaped by plasticity-driven convergence alongside ongoing clonal evolution, with distinct clones adopting shared transcriptional trajectories.
Clonal evolution and transcriptional plasticity shape metastatic dissemination routes in prostate cancer - Nature Communications
The impact of tumour heterogeneity on metastatic potential in prostate cancer remains poorly understood. Here, the analysis of single nuclei RNA sequencing and whole-genome sequencing from samples fro...
nature.com
Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.
Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination - Nature Communications
Understanding tumor heterogeneity and its impact on prostate cancer progression remains elusive. Here, single nucleus snATAC and snRNA sequencing of a multi-loci sampled cohort of advanced prostate ca...
nature.com
Hot from the press: Using single-cell chromatin accessibility and gene expression across ~300,000 cells, we show that prostate cancer dissemination involves phenotypic plasticity over clonal selection, with malignant cells converging toward an inflammatory-like state during lymph node spread.
Prostate cancer cells converge to an inflammatory-like state upon metastatic dissemination - Nature Communications
Understanding tumor heterogeneity and its impact on prostate cancer progression remains elusive. Here, single nucleus snATAC and snRNA sequencing of a multi-loci sampled cohort of advanced prostate ca...
nature.com
A major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...
An integrated view of the structure and function of the human 4D nucleome - Nature
The 4D Nucleome Project demonstrates the use of genomic assays and computational methods to measure genome folding and then predict genomic structure from DNA sequence, facilitatin...
nature.com
Our lab website just got a major refresh to better present: Our research philosophy: why chromatin is central to our work. A snapshot of our culture: diverse, collaborative, impact-driven. Our priorities: how we translate discoveries into clinical reality. Check it out
Lupien Lab
lupienlab.uhnresearch.ca
www.linkedin.com/posts/mathie...
Cancer is fundamentally a complex, multifactorial disease, and research fields have grown from viewing cancer through different mechanistic lenses. 1. Cancer as an immune-related disease. This… |...
Cancer is fundamentally a complex, multifactorial disease, and research fields have grown from viewing cancer through different mechanistic lenses. 1. Cancer as an immune-related disease. This vi...
linkedin.com
Our lab website just got a major refresh to better present: Our research philosophy: why chromatin is central to our work. A snapshot of our culture: diverse, collaborative, impact-driven. Our priorities: how we translate discoveries into clinical reality. Check it out
Lupien Lab
lupienlab.uhnresearch.ca
One of our top-rated posts on @altmetric.com this past was published in @nataging.nature.com. You can read 'Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries' here: spklr.io/63325BMpTZ
Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries - Nature Aging
In cross-sectional and longitudinal analyses of 86,149 participants across 27 European countries, Amoruso, Hernandez and colleagues identify multilingualism as a protective factor against accelerated aging, using biobehavioral age gaps.
spklr.io
DNA replication is only half the story. Cells actually replicate their chromatin, ensuring that both the DNA sequences and the chromatin states are faithfully maintained to preserve cell identity and function after division. Here's a glimpse of how this process unfolds, courtesy of theCrux:
Epigenetic Replication during DNA Replication - Replicating histones and DNA methylation
YouTube video by theCrux
youtube.com
