Happy to share my new paper from the @nogaleslab.bsky.social, combining #cryoEM and #cryoET to solve how Kinesin-4 KIF21B tail binds to microtubules! Our work shows how the specialized tails of KIF21 kinesins allow both #microtubule attachment and crosslinking. www.biorxiv.org/content/10.6...

Excited to see our recent work on the structural mechanism of α/β-tubulin biogenesis featured on the #CryoSPARC blog! 🎉 Many thanks to the team at @structurabio.bsky.social Biotechnology for highlighting both the study and the #cryo-EM workflow that made these structures possible. Read more here:

Structura Biotechnology@structurabio.bsky.social · 3w ago

🔬 Cryo-EM Reveals the Molecular Machinery of Tubulin Assembly In a recent study from @ucdavis.bsky.social, #cryoEM and #CryoSPARC were used to uncover the molecular mechanism underlying α/β-tubulin biogenesis! Read more on the latest CyoSPARC blog 👉 cryosparc.com/blog/tubulin

Excited to share our new preprint with the Yildiz and Janke labs on how Ndc80 and Ska complexes cooperate on microtubules through a SKA3 tether and tubulin tail interface to stabilize attachment! Congrats to Ju and Ipsita for leading this exciting study! www.biorxiv.org/content/10.6...

Congrats to Ana Galic and Kevin Li, who just graduated with honors in MCB @berkeleymcb.bsky.social, and to the brand new Dr. Trinity Cookis @trinitycookis.bsky.social 👨‍🎓👩‍🎓👩‍🎓🤩. Very best wishes for your next endeavors 💝

How do #tubulin dimers assemble and disassemble to form the #microtubule #cytoskeleton? Our recent #cryo-EM structures, published in #ScienceAdvances, demonstrate the processes of tubulin biogenesis and degradation. Click on the video and link below to learn more! www.science.org/doi/10.1126/...

How does Taxol bind microtubules, and why do tubulin isoforms matter for its efficacy? In my recent commentary in @natchembio.nature.com, I discuss Luo et al.’s mechanistic insights and their implications for designing isoform-selective microtubule-targeting drugs. www.nature.com/articles/s41...

New preprint from the lab 🎉: γ-tubulin is a novel target of the tubulin autoregulation pathway! Previously thought to exclusively target α- and β-tubulin mRNAs, we show that the TTC5–SCAPER–CNOT11 axis also degrades γ-tubulin mRNA, expanding the scope of this fundamental regulatory mechanism.

Happy to share that our new preprint from the Al-bassam lab at @ucdavis.bsky.social is out on @biorxivpreprint.bsky.social 🎉 The Structural Basis of Alpha/beta-tubulin Assembly and Disassembly by Tubulin Cofactors www.biorxiv.org/content/10.6...

The Structural Basis of alpha/beta-tubulin Assembly and Disassembly by Tubulin Cofactors

Microtubules polymerize from cytoplasmic pools of soluble αβ-tubulin heterodimers that support diverse cellular functions. The tubulin cofactors, TBCC, TBCD, TBCE, and the Arl2 GTPase, form TBC-DEG as...

biorxiv.org

Happy to share our paper is out now in @natcomms.nature.com : “Cryo-EM structures of the tubulin cofactors reveal the molecular basis of α/β-tubulin biogenesis.” 🎉 www.nature.com/articles/s41...

Excited to share our new preprint in collaboration with Ahmet Yildiz's lab. Check out how our team uncovers a novel binding footprint and motor regulation mechanism for MAP9 Congrats to Burak Cetin and @aryantaheri.bsky.social www.biorxiv.org/content/10.1...