Out on bioRxiv - chemogenetic activation of VTA astrocytes switches pro- to anti-addictive behavior dependent on prior drug exposure - via @mattjwanat.bsky.social and our collaborators at UT Health

bioRxiv Neuroscience@biorxiv-neursci.bsky.social · 2w ago

Ventral tegmental area astrocytes regulate drug-cue associations and drug intake https://www.biorxiv.org/content/10.64898/2026.07.20.739241v1

Please email me if you are interested in this postdoctoral position on gene expression and human disease mechanisms and apply here with a cover letter and CV: 2/2 (reskeets/reposts appreciated!!) cfopitt.taleo.net/careersectio...

"Biggest scam in modern political history."

Watch Director Bhattacharya's performance at CPAC really got to me. I chose to share some of my observations with him. Hold on... 1/11

Here We Go Sherman Bell GIF

ALT: Here We Go Sherman Bell GIF

media.tenor.com

Not to downplay the serious issue but what's with this title?.. www.nature.com/articles/s41... @natcomms.nature.com

Deadly heat stress conditions are already occurring for submission to Nature Communications - Nature Communications

The authors use a physiological approach, finding recent extreme heat events had deadly heat stress conditions, particularly for fully exposed older people. Conditions were well below wet-bulb tempera...

nature.com

Happy 30th birthday to this paper published March 22, 1996, one of the studies that moved chromatin biology from correlation toward mechanism. Brownell et al. linked a transcription-associated Tetrahymena HAT to yeast Gcn5p, providing a biochemical link for chromatin modification to gene activation.

Grad school application portals that require you to make an account to submit a reference letter should not exist /rant

I'm guest-editing a collection on "Enhancer-promoter interactions" at Genome Biology. Please send us your exciting stories! link.springer.com/collections/...

Don't post often but this is a good occasion: we wrote a huge review about mechanisms that preserve chromatin fidelity, and how its progressive degradation occurs in disease. Inspired by #oncohistones but mostly *not* about that. Bonus, snuck Horace into the title! academic.oup.com/narmolmed/ar...

Aere perennius: how chromatin fidelity is maintained and lost in disease

Abstract. Multicellular organisms arise from a single genome template in the zygote, necessitating the cells of the developing embryo to up- and downregula

academic.oup.com

Check out this 🧵 from @eimearlagan.bsky.social on our new Molecular Cell @cp-molcell.bsky.social paper! We show how the H3K27M Oncohistone reprograms chromatin in DMG, creating a specific dependency on CBX4/PCGF4-containing forms of cPRC1 👇

Eimear Lagan@eimearlagan.bsky.social · last yr.

Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).

Not that I wont be thrilled to grow a shaggy mouse...

The HuSH complex silences retrotransposable elements. We identify HuSH2, centered on TASOR2, targeting KRAB-ZNFs and interferon genes, balancing retrotransposon silencing and immune regulation. www.nature.com/articles/s41...