Basolateral amygdala dopamine transmits emotional salience - Nature Communications

The basolateral amygdala dopamine system has received little attention. Here, authors show that BLA dopamine plays a unique role in learning, by encoding the emotional salience of sensory cues to supp...

nature.com

NOT-OD-26-094: NIH Is Replacing Letters of Support with Letters of Collaboration to Reduce Administrative Burden

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: NIH Is Replacing Letters of Support with Letters of Collaboration to Reduce Administrative Burden NOT-OD-26-094. NIH

grants.nih.gov

Ventral tegmental area astrocytes regulate drug-cue associations and drug intake

Cocaine use disorder remains a critical public health concern with limited treatment options. Astrocytes are increasingly recognized as active regulators of neurotransmission and are emerging as impor...

biorxiv.org

Pancreatic mu opioid receptors regulate metabolism and ingestive behaviors

The mu opioid receptor system has long been recognized for its role in regulating ingestive behaviors and food palatability. However, beyond their rob…

sciencedirect.com

Interrogating roles for VTA dopamine neurons in locomotion and ultrasonic vocalizations elicited by different classes of rewarding drugs

urldefense.com

utep.interviewexchange.com

Addiction Neuroscience | The Role of Transcriptomics in Addiction | ScienceDirect.com by Elsevier

The generation of RNA transcripts in a cell is one of the first opportunities for interaction between DNA sequence and the environment (both at the organism and cellular level). Although many RNA transcripts get translated into proteins that are active in the cell, many other types of transcripts play critical roles in both the transcription and translation processes and ultimately, in how our bodies respond to our environment. Brain transcriptomics has the potential to mediate our acute responses to drugs of abuse and to reflect the changing cellular environment across the addiction cycle. Furthermore, RNA-based therapeutics are emerging as a significant treatment resource for many diseases. However, our knowledge about non-coding RNA transcripts, differences in transcript processing, and the interdependence among networks of transcripts is far from complete. This Special Issue features novel research into the role of transcriptomics and epigenetics in the neuroscience of addiction including predisposing factors and changing molecular phenotypes across the addiction cycle with the ultimate goal of identifying novel treatment and prevention approaches.

sciencedirect.com

Inside the new political screening that’s stalling NIH grants

Mandatory reviews by top health officials and checks for 235 disfavoured terms have left hundreds of vetted grant applications in administrative limbo.

nature.com

Careers

The Fraser Lab at the University of Minnesota (https://fraserlab.psych.umn.edu/) is recruiting a full-time research technician to support the lab. As a part of the Department of Psychology we are involved in the greater neuroscience research community at the University of Minnesota which provides excellent access to training and professional development. The Fraser Lab is interested in the neurobiological basis of motivated behavior and investigates how defined brain circuits contribute to behavioral regulation. We make use of modern neuroscience approaches to record and manipulate neural activity in real-time as rodents perform complex behavioral tasks to relate precise aspects of neural activity to well-defined psychological processes. To do so, we regularly use optogenetics, chemogenetics, calcium imaging, biosensors, pharmacology, and immunohistochemistry. Our ultimate goal is to decipher the neural mechanisms regulating behavior and to characterize how these are altered in psychiatric illness, such as addiction, or by differences in lived experience, such as after early life adversity, to potentially identify novel therapeutics. We seek a team member who can play a lead role in lab operations, collaborate closely with the PI, and engage in team-building and growth.Duties:Laboratory logistics, maintenance and operations (30%):

hr.myu.umn.edu

PA-27-037: Predoctoral to Postdoctoral Transition Award (Parent F99/K00 - Clinical Trial Not Allowed)

files.simpler.grants.gov

Glucose-Dependent Insulinotropic Polypeptide Receptors Are Expressed in the Lateral Septum and Reduce Electrically-Evoked Dopamine Release as well as the Ability of Cocaine to Increase Extracellular Dopamine

Tirzepatide, a dual agonist of the glucagon-like peptide 1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR), represents a new class of medication for obesity and type II diabetes treatment. Using laboratory mice, we show that GIPRs are present in the lateral septum (LS) in cells also expressing GLP-1R, particularly in the dorsolateral LS. Likewise, we show the coexpression of the dopamine (DA) D2 receptor (DRD2) in LS cells with GLP-1R in both the dorsolateral and intermediate portions of the LS. Using fast-scan cyclic voltammetry, we demonstrate that systemic GLP-1R or GIPR agonist treatment reduces both electrically evoked DA release in the LS and the ability of cocaine to increase extracellular DA levels. These data unveil a new central role for GIPR signaling and identify a potentially important cell type expressing both GLP-1R and GIPR upon which tirzepatide or other dual agonists may modulate DA homeostasis in the brain.

pubs.acs.org

Dorsal raphe nucleus enkephalin peptide modulates behavioral preference - Neuropsychopharmacology

Neuropsychopharmacology - Dorsal raphe nucleus enkephalin peptide modulates behavioral preference

nature.com

Cool, Cool, Cool - Detective Jake Peralta (B99)

Alt: Cool, Cool, Cool - Detective Jake Peralta (B99)

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Huh Kermit

ALT: Huh Kermit

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Grants Management Specialist

The incumbent performs limited grants management analysis assignments that are developmental and recurring in nature including functions such as the following: assisting a higher-level specialist in c...

usajobs.gov