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Antoine Taly

@ataly.bsky.social

Researcher at CNRS interested in the biophysics of proteins. Modelling membrane proteins and their interaction with ligands. Working in Paris.

174 Posts733 Follower573 Folgt
Jeff Groh@jeffgroh.bsky.social · last wk.

Avocados come in 2 varieties - A-types start each day female and switch to male midday. B-types do the reverse. In work just published from the last chapter of my PhD, we show this system evolved 40+million yrs ago and is regulated by alleles of 1 transcription factor www.pnas.org/doi/10.1073/...

Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado | PNAS

In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...

pnas.org

Dr. Jules Marien@marienj.bsky.social · 2w ago

New publication with Chantal Prévost and @sacquin-mo.eurosky.social is out in JPCB ! We show with all-atom MD simulations that disordered alpha-tubulin C-terminal tails wrap around the proline-rich region of the Tau protein, but not so much around its repeat domains pubs.acs.org/doi/10.1021/...

Simulations of an Extended Tau/Tubulins Interface Reveal a Complex Disorder–Disorder Interplay Mediated by the C-Terminal Tails

Building on a complex between a tubulin protofilament (PF) and a fragment of the Tau protein containing residues 169 to 367, we investigate the dynamics of the disordered elements of the system, namely the tubulin C-terminal tails (CTTs) and the Tau protein, using classical all-atom molecular dynamics simulations. Our results show that CTTs adopt a hook-like dynamic pattern on the bare PF while remaining highly mobile. The binding of Tau on the PF surface alters the dynamics of the αI-CTTs in a sequence-dependent manner. While the repeat domains of Tau are mostly maintained on the PF by weak and strong binding patches with the tubulin cores, the Proline-Rich Region (PRR) relies on the wrapping phenomenon of αI-CTTs to fuzzily stabilize its interaction with the PF. Our study thus provides a deep dive into the dynamic interplay between the Tau protein and the CTTs of microtubules, the latter being characterized extensively using a variety of disorder-adapted metrics.

pubs.acs.org

Timnit Gebru@timnitgebru.blacksky.app · 2w ago

Weeks ago, @chanda.blacksky.app sent me this declaration, written and signed by a bunch of mathematicians. But I only had time to read it yesterday, which ended up being right on time given a new round of hype falling exactly under the patterns this document notes.🧵 leidendeclaration.ai

Leiden Declaration on Artificial Intelligence and Mathematics

This declaration calls for action to address the challenges posed by the use of artificial intelligence within mathematics research.

leidendeclaration.ai

Extreme Temperatures Around the World@extremetemps.bsky.social · 2w ago

50 AGAIN IN CENTRAL ASIA ! 🇹🇲 50.0 Bagtiyarlyk 48.6 Kerki 47.8 Turkmenbat 46.2 BurdalykM 🇰🇿 49 Konyrolen 48.9 Arys 48.5 Shardara 46.5 ToleBi 45.2 Shkymkent 44.5 Bakanas 🇰🇬 44.6 Jhagy Jer NATIONAL RECORD AGAIN 43.5 Bishkek 40.1 Talas 🇹🇯 43.8 DushanbeM 42.5 Pendzhikent 🇺🇿 43.9 Dzizak 43.6 Samarkhand

Extreme Temperatures Around the World@extremetemps.bsky.social · 2w ago

‼️EXTRAORDINARY EVENT 50 DEGREES AT DAY 35 AT NIGHT IN CENTRAL ASIA MOST EXTREME EVENT EVER IN WORLD CLIMATIC HISTORY BY FAR DOZENS OF WORLD RECORDS SMASHED Nothing ever happened anywhere in the past 3 centuries remotely compare to what we witnessed today. MANY updates coming

Mara Wilson@marawilson.bsky.social · 3w ago

Thinking about how so many people I know said Don’t Look Up was so stupid and over the top and ridiculous but my environmental scientist brother was like “Nope, that’s exactly how it feels”

Structural Biology and Chemistry Dpt - Institut Pasteur@ipdbsc.bsky.social · 3w ago

Job Opportunity: #CNRS Chemistry - #InstitutPasteur Mid-Career Group Leader (Chemistry for Health) is open in Paris, France. This is a fantastic opportunity for a standout chemist to establish themselves in a world-class environment. research.pasteur.fr/en/call/mid-...

Mid-career Group Leader position in Chemistry for Health at Institut Pasteur, Paris - Research

Institut Pasteur and the CNRS are launching a joint call for a mid-career group leader position in Medicinal Chemistry and Chemistry for Health. We are looking for an experienced researcher (typically...

research.pasteur.fr

Alejandro Fábregas-Tejeda@alejandrofabregastejeda.com · 3w ago

If you have a background in #philosophy with relevant modeling skills, or a master's in climate science with interest in #philsci, consider applying to this PhD vacancy (@clpskuleuven.bsky.social)! Sylvia Wenmackers is an excellent mentor and one of the brightest & kindest scholars I know! #philsky

Centre for Logic and Philosophy of Science (CLPS)@clpskuleuven.bsky.social · 3w ago

Are you interested in climate modeling & #ML? Sylvia Wenmackers is looking for a #philsci PhD student to examine #uncertainty & #causality in climate science 👇🌍🌡️ www.kuleuven.be/personeel/jo... Apply by August 31 & please help us spread the word! #philsky #academicsky #MLsky #envhum #HPS

Three-dimensional rendering of the Earth showing the Americas and the Atlantic Ocean. A continuous blue-to-red color scale is mapped across the globe, with cooler colors concentrated at high northern latitudes and warmer colors over much of the tropics and subtropics. Land is shown as shaded gray topography with coastlines outlined in black, against a black background.
Djamé 🟥@zehavoc.bsky.social · 4w ago

Super urgent, I'm desperately trying to find two emergency reviewers for Neurips on a super interesting paper that study how LLM alignements evaluation depends on many different geopolitical factors. Seriously, I've been trying for a week, no one answered.

CNRS@cnrs.fr · 4w ago

#Communiqué 🗞️ Thierry Dauxois, Pdg du CNRS, nomme Sandrine Sagan directrice générale déléguée à la science du CNRS, à compter du 1er août 2026. Actuelle directrice de CNRS chimie, elle succèdera à Alain Schuhl dont le mandat s’achève fin juillet. 👉 www.cnrs.fr/fr/presse/sa...

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Ben Engel@cellarchlab.com · last mo.

Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩‍🔬👨‍🔬

Biozentrum, University of Basel@biozentrum.unibas.ch · last mo.

New Assistant (tenure-track) or Associate Professor position in Climate #Biophysics! Join our international research community to explore fundamental molecular mechanisms underlying climate-relevant biological processes. Apply by 7 Sept 2026! www.biozentrum.unibas.ch/de/open-posi...