@badfx75.bsky.social
MD/PhD working at Université Paris Cité, Hôpital Universitaire Robert-Debré, GHU APHP.Nord, NeuroDiderot INSERM UMR1141 & IHU Robert-Debré du Cerveau de l’Enfant. Interested in neurodevelopment, neuroinflammation and epilepsy
In our review out in @MyeloidC14405, we discuss how neuro–myeloid effects depend on tissue, cell identity, receptor subtype & signal dynamics. The field needs standardized reporting, stronger causal evidence & better translation to human biology. #Neuroimmunology #MyeloidCells #ANS
Thank you @fcyimmuno.bsky.social & @sfi-immunologie.bsky.social for highlighting our recent work 🙏🏻
FCYI@fcyimmuno.bsky.social · last yr.📢 April’s Article Award goes to François-Xavier Mauvais & team! Their Immunity paper reveals that rare spleen cells—metallophilic marginal zone macrophages—can rival dendritic cells in triggering antitumor T cell responses. 🧠🔥 A breakthrough for cancer immunotherapy! 🔗 tinyurl.com/sfiam25
Our special issue on #neuroimmunology is online! Check out the collection, with reviews from @jonykipnis.bsky.social @michellemonje.bsky.social @ugolinis.bsky.social @bethstevenslab.bsky.social @movahedilab.bsky.social Matteoli, Butovsky, Kim, Artis, & Prinz! www.cell.com/immunity/col... #AAI2025
🙏🏻 for the highlight @frenchdcsociety.bsky.social one important finding was the very efficient #vacuolar pathway in MZ #macrophages challenging the current view that #proteasome dependent pathways (active in DC1) are prominent to generate antigenic peptides for #MHC-I through #cross-presentation
The French DC Society - Club Francophone des DC (CFCD)@frenchdcsociety.bsky.social · last yr.👉 When splenic metallophilic marginal zone macrophages do antigen cross-presentation equally well as conventional DC1. Congrats to the team of Peter van Endert from @inem-necker.bsky.social for this work published in @cp-immunity.bsky.social www.cell.com/immunity/abs...
🙏🏻 Faculté de Santé @upcite.bsky.social pour la mise en valeur de notre publication @cp-immunity.bsky.social sur le rôle #anti-tumoral des #macrophages de la zone marginale de la #rate u-paris.fr/sante/des-ma... @inem-necker.bsky.social @hopitalrobertdebre.bsky.social @hopitalnecker.bsky.social
Des macrophages gardiens de la rate capables d’activer l’immunité contre les tumeurs | Faculté de Santé
u-paris.fr
Very proud to see my work published in Immunity. It has been a long journey but very enriching on a personal level. I am grateful to all the collaborators, the three reviewers for their very constructive -and challenging evaluation, and the Editor @cp-immunity.bsky.social
Immunity@cp-immunity.bsky.social · last yr.Online now: Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Splenic metallophilic marginal zone macrophages (MMMs) prime CD8+ T cell responses via MHC class I cross-presentation. Cross-priming by MMMs protects against a splenic tumor in the absence of dendritic cells. www.cell.com/immunity/ful...
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages are positioned strategically within the spleen to process internalized blood-borne materials. Mauvais et al. find that these CD169+ macrophages cross-prime CD8+...
cell.com
Metallophilic CD169+ marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors using a proteasome- and cDC1-independent pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...
Online now: Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors
Metallophilic marginal zone macrophages are positioned strategically within the spleen to process internalized blood-borne materials. Mauvais et al. find that these CD169+ macrophages cross-prime CD8+ T cell responses to internalized antigens using a proteasome-independent pathway, contributing to antitumor immunity independently of type 1 conventional dendritic cells.
dlvr.it
🚨 New: Spleen-resident macrophages (MMMs) can directly activate CD8+ T cells to fight tumors – independently of dendritic cells. They use a vacuolar MHC-I pathway & need Batf3 for this antitumor response. 🧠 A game-changer for immunotherapy? 🔗 www.cell.com/immunity/abs... @cp-immunity.bsky.social
