At the New River Gorge National Park, the NPS has a message for you. Particularly relevant for us, scientists, to decrease our environmental footprint. Are you using the recycling facilities offered by your university/institute ? Safety permitting, are you considering to reuse plastic labware?

The People Behind Our Science Meet Nolva, the barista, cashier, store manager and all-in-one person at the Building 50 cafeteria at the NIH Intramural Bethesda campus.From morning till 3:30 pm, she does this with a great attitude, which is exemplary for PIs and trainees alike. Thank you Nolva.

An article that I read today in Nature on how AI is overwhelming cyber security monitoring tools resonated deeply with an episode later this evening on NPR’s The World ……. 1/n AI is set to completely transform cybersecurity — here’s how researchers must prepare www.nature.com/articles/d41...

AI is set to completely transform cybersecurity — here’s how researchers must prepare

As automated tools accelerate both the discovery and the exploitation of software vulnerabilities, organizations must redesign their defences and workflows to keep pace.

nature.com

Excited to see this collaboration now in print. Dye chemistry meets AI-designed proteins. Three small, orthogonal tags; lifetime modulation; split versions. Request the free dyes at dyes.janelia.org www.science.org/doi/10.1126/...

De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging

Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...

science.org

If you are a parent, I hope that you are at least as upset as Mark and I are, hopefully more. Thank you for highlighting this, @markhisted.org

Mark Histed@markhisted.org · 3w ago

My 10 year old tells me his friends at school bet on sports (“dad they made money on the Eagles!”) via DraftKings.

Lab of Gisou van der goot @gisouvggoot.bsky.social shows that no less than three palmitoylation enzymes, zDHHC7, zDHHC3 and APT2 are involved in regulating Capillary Morphogenesis Gene 2 (CMG2/ANTXR2). #proteinlipidation #proteinpalmitoylation #zDHHC3 #zDHHC7 #APT2 www.nature.com/articles/s41...

Protein S-acylation, commonly known as protein palmitoylation, targets thousands of proteins. Here, role of protein S-acylation in cell wall damage response in plants, Very intriguing. Congratulations to all authors. #proteinlipidation #proteinpalmitoylation #PAT10 www.science.org/doi/10.1126/...

S-acylation switches the fate of a plant peptide precursor in cell wall damage responses

A lipid tag mediated via S-acylation redirects the precursor of a plant elicitor peptide to alter its fate upon cell wall damage.

science.org

Happy Fourth to fellow Americans. May the pursuit of life, liberty and happiness belong to everyone in this world, not a select few. My day started with listening to this podcast. Quote from the producers - " explores what it means to have a chance to die free." www.latinousa.org/2026/07/03/r...

Released To Die: Episode 3 - Latino USA

After months out of prison, Frank Ross’ dementia has progressed. At times, he can no longer remember why he needs to wear the GPS monitor the law requires, putting his freedom at risk.

latinousa.org

Don't let your leftovers go to waste. Cookbook authors share clever storage techniques — like an "Eat Me First" box in your fridge — and cooking tricks to help you make the most of your food scraps.

This mindset shift can help you get better at using up your leftovers

Don't let your leftovers go to waste. Cookbook authors share clever storage techniques — like an "Eat Me First" box in your fridge — and cooking tricks to help you make the most of your food scraps.

n.pr

“The whole point of AI tools is that I no longer need to retain information in my biological memory. My biological memory is for other things now. Important things. Like my Netflix password” 😂 inpreparation.substack.com/p/opinion-i-...

Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

inpreparation.substack.com

I am the father of two biological kids and a perennially infant lab that seems to refuse to grow up. To like minded souls and to all others, Happy Father's Day. We are all fathers, of our kids, our workplace, our communities, of our land, our country and the planet. We just have to take ownership.

Dynamic cycles of palmitoylation and depalmitoylation of the tight junction protein CLDN12 in the host influences the susceptibility of host cells to Hepatitis C virus. #proteinlipidation #proteinpalmitoylation #zDHHC7 #HCV #HCC journals.asm.org/doi/10.1128/...

Palmitoylation of CLDN12 regulated by ZDHHC7 and APT1/2 promotes hepatitis C virus entry | Journal of Virology

HCV infection poses a significant global health burden. Despite the remarkable efficacy of direct antiviral agents, developing new strategies targeting host factors is crucial for addressing drug resi...

journals.asm.org

How palmitoylation regulates protein function and structure beyond membrane localization is very poorly understood. Human organic solute transporter (OST) α/β uses palmitoylation to facilitate substrate transport. #proteinlipidation #proteinpalmitoylation #OST #transporter rdcu.be/fpxyI

Structural insights into OSTα/β-mediated transport of bile acids and steroid conjugates

Nature Structural & Molecular Biology - OSTα/β regulates bile acid and steroid conjugate homeostasis. Sun, Tian, Low and colleagues reveal structures of the human OSTα/β...

rdcu.be

This week, a group of about 50 students and faculty members from 30 universities in IDeA states visited 10 labs at the NIH Intramural Research Program (IRP). They were attending the 10th National IDeA Symposium of Biomedical Research Excellence (NISBRE) conference in Bethesda. 1/n

Meet Joanna Engstrom. At the 2026 FASEB conference on Trace Elements in Biology and Medicine, she is the star of the show. From taking group photos on her cellphone to herding attendees into elevators, to making sure the coffee is strong, she sees that everything is going as smoothly as possible.

At 2026 FASEB @faseborg.bsky.social conference on Trace Elements in Biology and Medicine, heartening to see many young scientists at the session on academic careers. Thanks to the panelists for their honesty and transparency. Hope we can sustain the interest and enthusiasm of these youngsters.

Want to start your independent research career with your ideas, be within a thriving environment with more than 1000 PIs, have the world's largest research hospital to collaborate with, and are excited about being a public servant doing science for the benefit of human health ?Apply today -

Article in WaPo describing pioneering work spearheaded by Greg Verdine , Kevan Shokat and others targeting Ras that “has shown unprecedented success in treating pancreatic cancer, upending conventional wisdom about the disease”. Very proud moment as a Verdinian. Gift link - wapo.st/4vceYox

How scientists found a weakness in one of the deadliest ‘undruggable’ cancers

An experimental pill has shown unprecedented success in treating pancreatic cancer, upending conventional wisdom about the disease.

wapo.st

We have a late opening for postbac in my lab starting this summer. Please reshare, repost.

Anirban Banerjee@banirbn.bsky.social · last yr.

Interested in chemical mechanisms of membrane proteins ?We have an opening for postbac fellows. Please share and repost. Thanks ! Our research focuses on understanding the chemical and cellular mechanisms of integral membrane enzymes and transition metal transporters. bit.ly/42jWXYD. /n

Foundation for the National Institutes of Health (FNIH) has started an NIH Alumni Network to foster connections among former NIH staff and provides information, opportunities, and resources. fnih.org/nih-alumni-n...

NIH Alumni Network | FNIH

fnih.org

#proteinlipidation #proteinpalmitoylation #ALS #SOD1 #COMMD1 www.jneurosci.org/content/earl...

COMMD1 Induces Copper Deficiency of SOD1 by Inhibiting the Palmitoylation of CCS in ALS

Mutations in superoxide dismutase 1 (SOD1) compromise its metal-binding capacity, resulting in protein misfolding and aggregation, which ultimately induces cellular apoptosis in amyotrophic lateral sc...

jneurosci.org

All expenses paid opportunity to visit the NIH campus for late stage grad student/early stage postdoc in biophysics, who are interested in pursuing the next stage of their career at the NIH Intramural Program. Deadline May 29th. Apply today ! Please reshare, repost. www.niddk.nih.gov/research-fun...

Biophysics Fellows Research Conference at the NIH - NIDDK

The conference provides predoctoral candidates and postdoctoral biophysics researchers the opportunity to explore resources and research opportunities at NIH.

niddk.nih.gov

Mitra Rana and I wrote a Preview of the article (link in comment) by Qi Hu and lab at Westlake University where they fuse a depalmitoylation enzyme to RAS generating a constitutively depalmitoylated RAS. 1/n www.sciencedirect.com/science/arti...

Engineering NRas palmitoylation to hook zDHHC inhibitors

Protein palmitoylation is an important lipidic post-translation modification catalyzed by the zDHHC protein acyltransferases. In this issue of Cell Ch…

sciencedirect.com

Palmitoylation of BRAF by zDHHC5, a zDHHC protein palmitoyltransferase family member, stabilizes BRAF protein and plays a critical role in tumour progression in cholangiocarcinoma. #proteinlipidation #proteinpalmitoylation #zDHHC5 #Cholangiocarcinoma #BRAF www.sciencedirect.com/science/arti...

ZDHHC5-mediated BRAF palmitoylation activates the MAPK pathway and drives cholangiocarcinoma progression

Cholangiocarcinoma is a highly malignant tumor with an increasing incidence around the world. Discovery of novel molecular targets and effective thera…

sciencedirect.com

Protein palmitoylation is important in the pathogenesis of many viruses. Palmitoylation of SARS-Cov-2 ORF3a by zDHHC18 is a central regulator of ORF3a stability and virulence. #proteinlipidation #proteinpalmitoylation #zDHHC18 #SARS-CoV-2 #ORF3a advanced.onlinelibrary.wiley.com/doi/10.1002/...

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Palmitoylation by ZDHHC18 blocks ORF3a K27-linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation thro....

advanced.onlinelibrary.wiley.com

#proteinlipidation #proteinpalmitoylation #PPT1 #GAP43 #NeurodevelopmentalDisorder PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function | Science Advances www.science.org/doi/10.1126/...

PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function

Disrupted lipid signaling in neurons impairs brain connectivity, revealing a target for epilepsy, neurodevelopmental disorders.

science.org

TDP43 is palmitoylated by the zDHHC enzyme zDHHC23. Importantly, TDP43 palmitoylation is decreased in the familial ALS-associated TDP43 mutants, suggesting involvement in ALS pathogenesis. . #proteinlipidation #proteinpalmitoylation #zDHHC23 #ALS #TDP43 www.sciencedirect.com/science/arti...

S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis

TDP43 inclusion bodies are widely present in the majority of patients with familial and sporadic amyotrophic lateral sclerosis (ALS). The mechanisms r…

sciencedirect.com

Thanks very much for sharing. Congratulations Kevan, Greg and all involved. This is inspirational. A must read for aspiring biomedical scientists.

Karen S Wilcox, PhD (she/her)@karenswilcoxphd.bsky.social · 3mo ago

Gift link because this is important stuff. Pancreatic cancer is horrific and breakthroughs in treatment need to be shared around. Also, science. #PancreaticCancer Explore this gift article from The New York Times. You can read it for free without a subscription. www.nytimes.com/2026/05/12/h...

Congratulations to my colleagues in the NIH intramural program Okihide Hikosaka and Alan Sher for being elected members to the NAS @nationalacademies.org www.linkedin.com/posts/congra...

🙌 Congratulations to two NIH senior scientists on being elected as members to the U.S. National Academy of Sciences! Dr. Okihide Hikosaka serves as head of the Laboratory of Sensorimotor Research… | ...

🙌 Congratulations to two NIH senior scientists on being elected as members to the U.S. National Academy of Sciences! Dr. Okihide Hikosaka serves as head of the Laboratory of Sensorimotor Research at ...

linkedin.com

For context: Chemsketch was a free (for academic use?) chemical structure editor. Revvity bought Chemdraw, a commerical editor, few years back and took it from perpetual license to annual subscription and ramped up prices massively. Now they're buying up whatever competition there still was.

Simon Hammann@simonhammann.bsky.social · 3mo ago

I was not aware. But ChemSketch is about to cost a few hundred euros per year I guess. Cool cool cool cool #Chemchat 🧪