First antidote to anthrax? 20 years ago we started working on S-acylation in the context of anthrax toxin entry. CMG2 is so hard to work on, but now we figured out! Amazing long term effort of Laurence Abrami, started by Sanja Blaskovic, with help of many lab members. www.nature.com/articles/s41...
Dynamic S-acylation controls CMG2 maturation extracellular matrix regulation and anthrax toxin susceptibility in vivo - Nature Communications
Regulation of membrane receptors governs extracellular matrix homeostasis and host-pathogen interactions. Here, authors show that reversible S-acylation controls CMG2 maturation, trafficking, and sign...
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