Becca Williams

@beccasue99.bsky.social

Postdoc @ Cambridge Uni MRC Cognition & Brain Sciences Unit. Love brains 🧠. Love talking about brains 😍. Not a zombie. She/her

Want to improve your writing? Blogging genuinely taught me not only how to write better, but that I also have interesting things to say! Who knew? If you've ever considered blogging - why not just give it a whirl? You might learn something about yourself 🤔 #academicsky #neuroskyence #scicomm

Dementia Researcher@dementiaresearcher.bsky.social · 9mo ago

Ever thought blogging but convinced yourself you were not ready? Rebecca Williams @beccasue99.bsky.social did too. Three years and 26 blogs later, she discovered something surprising. She had plenty to say, and writing helped her say it better. www.dementiaresearcher.nihr.ac.uk/blog-why-you...

Fancy a forray into policy? 🗣 Specifically, are you an ECR that thinks its too early to engage with policy? To thee I say "pfft" - its never too early! Get used to communicating science now and I guarantee it will pay off later 😉 #academicsky #scicomm www.csap.cam.ac.uk/case-studies...

Rebecca Williams - Centre for Science and Policy

"The opportunities that CSaP has provided have been transformative. The connections and skills I've developed have fundamentally changed how I approach my research and its potential impact."

csap.cam.ac.uk

Its not all smooth sailing - and that's why I recommend getting yourself a might fine crew for the journey 🏴‍☠️😄 Some of my reflections on the final stretch of #PhD life which I hope might be helpful to those coming along next! #academicsky #WomeninSTEM

Dementia Researcher@dementiaresearcher.bsky.social · 10mo ago

Climbing the thesis mountain is wild but @beccasue99.bsky.social reminds us that perfection is not required and cheesy chips after submitting taste incredible. pod.fo/e/35d311

Reflections on a fab session at #CCN25 - how might gamification fit into #dementia research? 🎮 Would love to hear others' thoughts on this one 😊 #neuroskyence

Dementia Researcher@dementiaresearcher.bsky.social · 11mo ago

What if dementia research felt more like playing a game than taking a test? 🎮 @beccasue99.bsky.social explores how gaming could make research more engaging and realistic — from Sea Hero Quest to futuristic lab simulations. www.dementiaresearcher.nihr.ac.uk/blog-gamifyi...

🎃 Halloween meets sleep science💤: Our ECSM team's “Polysomnography Pumpkin” brought sleep science to the spooky season - earning second place at Oxford’s Dorothy Crowfoot Hodgkin Building Games! Brains, electrodes, and a few spiders included.🧠

Bild

Come listen to John Duncan and myself discussing his new book on 25 Nov. So much insight into the human condition. Definitely not an event to miss!

MRC Cognition and Brain Sciences Unit, University of Cambridge@mrccbu.bsky.social · 12mo ago

What does it mean to be both animal and thinker? Join @moatazassem.bsky.social and John Duncan on 25 November at Murray Edwards College for the launch of John’s new book ‘The Animal and the Thinker.’ Get your tickets here: www.eventbrite.co.uk/e/the-animal...

NEW PREPRINT ❗️ A slightly different take on the old problem of #apathy - we find evidence that apathy is linked to confidence on action outcomes 🎯 🧠This confidence may be underpinned by self-regulation of prefrontal superficial pyramidal neurons #neuroskyence www.biorxiv.org/content/10.1...

Apathy as a Loss of Prior Precision on Action Outcomes

Apathy is common in neurological disease, associated with poor prognosis and limited treatments. Current models posit that goal-directed actions are reduced because costs or effort outweigh the expect...

biorxiv.org

It's terrifying out here in #AcademicSky... and yet I'm still willing to give it a whirl. At least for now. Join me for my latest blog as I share some reflections on the uncertainty (and maybe thrill??) of careers in the academic sector 🤔 #neuroskyence #WomeninSTEM

Dementia Researcher@dementiaresearcher.bsky.social · last yr.

“It feels at times that the only certainty is rejection.” Rebecca Williams @beccasue99.bsky.social shares her reflections on life towards the end of a PhD and at the edge of the academic map. www.dementiaresearcher.nihr.ac.uk/blog-uncerta...

Normative neuroanatomical modelling to quantify individual 🧠atrophy patterns in #FTLD - results from this UCL and Brunel collaboration are now out: link.springer.com/article/10.1...

Neuroanatomical normative modelling in frontotemporal lobar degeneration: higher heterogeneity in the behavioural variant - Journal of Neurology

Introduction Frontotemporal lobar degeneration (FTLD) includes heterogenous diseases: behavioural variant frontotemporal dementia (bvFTD), primary progressive aphasias (PPA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). We applied neuroanatomical normative modelling to quantify individual atrophy patterns and heterogeneity within and between FTLD forms. Methods We included 160 participants across FTLDNI and 4RTNI studies: controls (n = 15), bvFTD (n = 22), nfvPPA (n = 14), svPPA (n = 21), CBS (n = 43) and PSP (n = 45). Using cortical thickness and subcortical volumes from 3T MRIs, we applied normative modelling with a large healthy reference dataset (n = 58,836), further accounting for age, sex, and scanner. Outlier regions (z < – 1.96) were used to compute total outlier counts (tOC) and Hamming distances, capturing individual atrophy patterns and inter-subject dissimilarity. Results bvFTD, svPPA, CBS and PSP showed significantly higher cortical tOC than controls, with all groups showing higher subcortical tOC than controls, especially svPPA and PSP. bvFTD, svPPA, CBS and PSP had significantly higher cortical Hamming distance scores than controls, with higher scores in bvFTD and svPPA than nfvPPA and PSP. svPPA and PSP had significantly higher subcortical scores than controls and CBS. Greater disease severity (measured using the Clinical Dementia Rating—CDR for PSP and CBS, and the CDR® plus NACC-FTLD global scores for FTD variants) was associated with increased tOC and dissimilarity, highlighting the link between clinical progression and neuroanatomical heterogeneity. Conclusions The pronounced heterogeneity within and between FTLD subtypes (particularly in bvFTD) increases with disease progression and may reflect distinct underlying pathologies. This supports the development of subtype-specific biomarkers and emphasize the need for personalized diagnostic and therapeutic strategies.

link.springer.com

Worried about what comes next? Me too! The solution? No idea - but here's some advice I've been giving students for years that I'm now hoping to turn inwards 😄 #AcademicSky #science #careers

Dementia Researcher@dementiaresearcher.bsky.social · last yr.

Career paths aren’t linear. PhD Student Rebecca Williams @beccasue99.bsky.social reflects on research, life choices, and learning from every step. www.dementiaresearcher.nihr.ac.uk/blog-career-...