bedzhov lab

@bedzhovlab.bsky.social

Max Planck Institute for Molecular Biomedicine Embryonic Self-Organization research group Bedzhov lab / 🇪🇺🇩🇪🇮🇳🇨🇳🇧🇷🇬🇷🇧🇬 www.mpi-muenster.mpg.de/176301/bedzhov

We found that in addition to Fgf/Mek, Erk is activated by Aurora kinase A to promote differentiation. During cell division, Erk localizes at the centrosomes, where its activation depends on Plk1. Congrats to Fei & the team! doi.org/10.1126/scia... 🐁 @sfb1348.bsky.social @mpi-muenster.bsky.social

Developmental regulation of Erk signaling by mitotic kinases

The mitotic kinases aurora A and polo-like kinase 1 act as cell-intrinsic regulators of Erk signaling in pluripotent stem cells.

doi.org

This is our Tron-inspired candidate cover design for Dev Cell, illustrating the temporal sequence of epithelial morphogenesis during preimplantation development. Although the image was not selected for the cover, we enjoyed developing the concept. t.co/XQ43VeLSR0

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“Implantation is the most difficult and unpredictable stage,” wrote IVF pioneer Sir Robert Edwards. In this review, we explore the cell shape and tissue dynamics in the early mouse embryo, focusing on the peri-implantation stages of development and embryonic dormancy.🐁 doi.org/10.1016/bs.c...

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