🎉 Our paper is out in Cell Systems @cp-cellsystems.bsky.social ! How does an embryo build an energy-efficient fractal lung before the first breath? 📄 doi.org/10.1016/j.ce... 🧵 bsky.app/profile/iberd.bsky.social/post/3lfrdth6k4c22 @maltemederacke.bsky.social @kevinyamauchi.bsky.social

Dagmar Iber & CoBi@iberd.bsky.social · 2y ago

How does an #embryo build an energy-efficient #fractal #lung in time for the first breath at birth? 🫁 Discover the mechanical forces shaping the bronchial tree in our latest preprint: #LungDevelopment #Mechanobiology doi.org/10.1101/2025... 👇Thread 🧵(1/9)

What makes the MBL Physiology course a “life-changing experience”? According to one course participant this summer, there’s more than one reason why. Watch the full video and hear what made the experience so meaningful: go.mbl.edu/77pnuj

Our paper on nonlocal decoding is now out in @physrevlett.aps.org! See below for a thread about the preprint 🧵 👉 journals.aps.org/prl/abstract...

David Brückner@davidbrueckner.bsky.social · 8mo ago

How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔 We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns. buff.ly/w56OUJT

The "dead organ" model of the #aging #ovary needs a rethink ? it may be an actively remodeling tissue with the potential in inter-organ signaling during aging? Postmenopausal ovaries aren't just quiescent fibrous tissue.

Thrilled to share our new paper on cell extrusion. A beautiful study with a tremendous amount of data, led by the fantastic @fanny-wodrascka.bsky.social ! www.biorxiv.org/content/10.6...

🪲🪰 Our preprint is out! This was a team effort with @wolframponisch.bsky.social, @matthewabenton.bsky.social and Ewa Paluch. We asked whether Drosophila and Tribolium use the same cell behaviours to fold their embryos during gastrulation. 🧵👇 www.biorxiv.org/content/10.6...

Morphospace analysis reveals divergent cellular behaviours driving tissue internalisation during insect gastrulation

During gastrulation, embryonic epithelia undergo large-scale remodelling to internalise the mesoderm. Whether the cellular mechanisms underlying these tissue deformations are conserved across species ...

biorxiv.org

🚀Excited to share our latest efforts in bringing highly multiplexed whole-mount imaging to intact multicellular systems! Shield-4i: an integrated platform to study multi-scale information flow in 3D embryos and embryo-like systems. Kudos to @rhornb.bsky.social for this major milestone in the lab!🚀

Excited to share that our work on ‘How the gut gets patterned during regeneration’ is out now cell.com/cell/fulltext/S0092-8674(26)00696-3 Thanks a lot to @priscaliberali.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social and all co-authors! 🧵

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

Annual killifish continue to surprise us: they make neutrophils before almost every other cell type, even before gastrulation. Neutrophils usually arise from the lateral plate mesoderm (forming in cyan), but in killifish they are already patrolling around the embryo in gold. tinyurl.com/killiphil

🧰 New tool alert! ⚙️ #MorphoGrad, an open-source toolbox for simulating reaction–diffusion systems in 1D and 2D tissues, with cell-to-cell parameter heterogeneity & graphical user interface. No heavy coding required. Explore complex morphogen gradient models interactively. doi.org/10.1016/j.xp...

MorphoGrad: A MATLAB toolbox for simulating steady-state morphogen gradients under cell-to-cell variability

Studying morphogen gradient-based tissue patterning in silico while accounting for biological variability remains challenging. Here, we present a MATLAB-based protocol for simulating steady-state morp...

cell.com

How do sperm and egg fuse? Surprisingly, we still don’t fully know… Our field has uncovered many pieces of the fertilization puzzle, but not how they fit together. We identify ✨ SPARK ✨ - a conserved sperm complex that couples sperm-egg binding to fusion. tinyurl.com/34cm4xat Read on! 🧵👇

Summer is coming, but how will you maximize your picnic space when everyone else is doing the same? In our new preprint, we show that branched cells may have an elegant solution: As cells grow and repel neighbors, they don't just cover space, but reach a hidden order called hyperuniformity! 🧪⚛️

Welcome 2026 @dev-journal.bsky.social Pathway to Independence (PI) fellows Maëlle Bellec, @iamzico.bsky.social, @evhealy.bsky.social, @josepmercadal.bsky.social, @nikhil-mishra.bsky.social, Jessica Perochon, Yamini Ravichandran & Margherita Zamboni More info journals.biologists.com/dev/pages/pi...

New Preprint alert!🚨 Super excited to share my postdoc work now on BioRxiv. How does PRC2 loss lead to developmental failures? We combined rapid protein degradation with TLS embryoid models to uncover temporal and lineage-specific dependencies 🧬. Preprint: doi.org/10.64898/2026.04.18.719361

We tracked a zebrafish tail tip for 30h of light-sheet imaging. It didn’t exist at t=0. LiLiTTool: CoTracker3 + object detection → real-time microscope steering. 3D, multi-ROI, open source. www.biorxiv.org/content/10.6... #bioimaging #lightsheet thanks @jytinevez.bsky.social

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis

Gene expression patterns underlie development, but their systematic detection in whole embryos has remained elusive. We introduce a whole-embryo imaging platform using multiplexed error-robust fluores...

science.org

We’re excited to share our latest preprint on Fractal: our approach towards FAIR bioimage analysis at scale with OME-Zarr-native workflows. Fractal defines interoperable tasks on OME-Zarr and provides a platform for TB-scale image analysis. (1 / 10🧵) www.biorxiv.org/content/10.6...

Join us in Vienna for the European 🐠 🐟 meeting👇👇we are excited to welcome researchers working with all fish models in Europe and beyond!We provide travel fellowship opportunities to make the meeting as inclusive as possible 😊

Pauli Group (posts by Andi Pauli)@pauligroup.bsky.social · 6mo ago

Join us in Vienna for the biggest international 'FISH' meeting in 2026! No matter which fish is your favorite model - zebrafish, medaka, killifish, cavefish, Danionella, cichlids, stickleback, you name them...- this meeting is for you! www.ezm2026.org Abstract submission deadline is March 15th.

Happy to share this work from Carlos Camacho de la Maccora that reveals how rates of posterior progenitor addition and anterior vacuolation are balanced across the notochord. With Alberto Ceccarelli and @osvaldo-chara.bsky.social we present a model of long-range communication to provide robustness.

A 🆕 #Ichthyosporea story Led by@margaridaaraujo.bsky.social, in Co. @gautamdey.bsky.social & @hiralshah.bsky.social+🔥team across @embl.org & @sciencesunige.bsky.social We finally have a look at what #microtubules are doing during #cellularization in #Sphaeroforma ▶️ tinyurl.com/MTSARC #ProtistsOnSky

it's always fun to look back at phd data in @heisenbergcplab.bsky.social - here a wave of acentrosomal microtubule asters forming in maturing zebrafish oocytes, bringing the cytoplasm into motion...

Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon. Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity. Plus: a clever way to measure cell volume. www.pnas.org/doi/10.1073/...

Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS

Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is know...

pnas.org

In @natphys.nature.com, they demonstrated that the zebrafish embryo “reads” and correctly interprets the zygote’s geometry during the initial few minutes of its existence. They discovered ... 📷 C.-P.Heisenberg, N. Mishra, Y. I. Li (from left to right).

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

bioRxivpreprint@biorxivpreprint.bsky.social · 8mo ago

Organelles harbour pH gradients https://www.biorxiv.org/content/10.64898/2025.12.12.694065v1

The lab’s first pre-print! We investigated how growth-inducing Erk activity waves are regulated in regenerating zebrafish scales. We discovered that Erk waves are followed by waves of expression of their own inhibitors, as predicted by excitable waves theory. tinyurl.com/26r2cmpj

Happy to present the final version of our Cadherin and gastruloid manuscript, online at @cp-cellreports.bsky.social. www.cell.com/cell-reports... Initially in BiorXiv (www.biorxiv.org/content/10.1...) 1/12

Cadherins modulate the self-organizing potential of pseudo-embryos

Gastruloids derived from ES cells mimic embryonic patterning through robust self-organization. Mayran et al. uncover that this competence depends on a cadherin switch regulated by Snai1-driven E-cadhe...

cell.com

🎉 I am very glad to share that our paper on the rapid isotropic light-sheet microscope has just been published in Nature Biotechnology @natbiotech.nature.com. 🔗 Read the full article: www.nature.com/articles/s41...

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue - Nature Biotechnology

A light-sheet microscope built from off-the-shelf components enables high-resolution clear tissue imaging.

nature.com

Why do whales and elephants have much lower rates of cancer than expected? "Species with a lower cancer prevalence and mortality risk are those with a higher presence of cooperative and caring habits, while the opposite is found....:" www.science.org/doi/10.1126/...

Coevolution of cooperative lifestyles and reduced cancer prevalence in mammals

While cooperative mammals evolve reducing cancer prevalence, oncogenes can be maintained by selection in competitive species.

science.org

#ZebrafishZunday: Cytoplasmic (or ooplasmic) streaming leads to the segregation of embryo from yolk granules. Credit to @shamipourshayan.bsky.social & @heisenbergcplab.bsky.social. 🧪

@sushantbangru.bsky.social and @rdiegmiller.bsky.social new review on regeneration is out in Nature Reviews Molecular Cell Biology. A fun piece to write and another great collaboration with @kenposs.bsky.social.

Nature Reviews Molecular Cell Biology@natrevmcb.nature.com · 10mo ago

New Online! Signal control during tissue regeneration in adult animals