What matters most for childhood brain organization? We analyzed 649 variables. The answer: Socioeconomics (SES); with brain patterns pointing at sleep & stress as drivers. Even brain-IQ associations were better explained by SES. In Science today: www.science.org/doi/10.1126/...

Brain network responsible for Parkinson’s disease identified

Brain network responsible for Parkinson’s disease identified

A brain network first identified by Washington University in St. Louis School of Medicine researchers, called SCAN, is shown in a new study to be the neurological basis for Parkinson’s disease. Patients receiving treatments targeted to this brain region, rather than to surrounding areas, experienced greater improvements in symptoms.

source.washu.edu

Scientists just discovered a key brain network affected by Parkinson’s disease. The finding could change how doctors understand symptoms and lead to better treatments. 🧠 bit.ly/4qdpLMf

A new study suggests Parkinson’s may stem from disruptions in a little-known brain network, reshaping how doctors think about the disease. trib.al/XFtsWKn

A new study suggests Parkinson’s may stem from disruptions in a little-known brain network, reshaping how doctors think about the disease.

A new study suggests Parkinson’s may stem from disruptions in a little-known brain network, reshaping how doctors think about the disease.

trib.al

I’m very excited about this new work describing the specific cortical-striatal circuits that are altered in Parkinson’s Disease and that should be targeted for optimal PD treatment. www.nature.com/articles/s41...

Thanks to @shawnballard.bsky.social for this terrific synopsis of our latest work in @cellpress.bsky.social. The details of how stimulant medications like Ritalin work inside the brain will surprise you! doi.org/10.1016/j.ce...

WashU Medicine@washumedicine.bsky.social · 7mo ago

What if we've misunderstood how ADHD stimulants work? WashU Medicine brain imaging and child neurology teams joined forces to uncover where in the brain these drugs act — knowledge that could improve how attention disorders are treated. medicine.washu.edu/news/stimula...

This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...

Check out some compelling and timely work by @nasiametoki.bsky.social on sex vs gender differences in the developing adolescent brain!

Nasia Metoki@nasiametoki.bsky.social · 10mo ago

Is resting-state functional connectivity (rsFC), cortical thickness (CT), or cortical volume more effective at capturing sex and gender differences in the brains of preadolescents? Check out our new article (doi.org/10.1016/j.dc...) now out in Developmental Cognitive Neuroscience.

Ever wondered if your interesting brain-behavior correlation was over- or under-estimated due to head motion, but were afraid to ask? We’ve created a motion impact score for detecting spurious brain-behavior associations, now available in Nature Communications! doi.org/10.1038/s414...

Poor image quality introduces systematic bias into large neuroimaging datasets, new study of ABCD data shows. By Natalia Mesa www.thetransmitter.org/spectrum/poo...

Poor image quality introduces systematic bias into MRI data

Analyses that include low-quality MRI data underestimate cortical thickness and overestimate surface area, according to new work from the ABCD Study.

thetransmitter.org

Excited to see the latest paper from @bttyeo.bsky.social's lab finally published in Nature! Now I know the most economical way to spend my grant money on MRI! No surprise, sample size matters, but adequate sampling in scan time can reduce the cost of sampling adequate numbers of participants.

Thomas Yeo@bttyeo.bsky.social · last yr.

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

Once again, if you give @gordonneuro.bsky.social et al a network, they're going to want to characterize its subnetworks... A thought provoking read on the AMN (née CON) and the brain architecture of the decision-action-feedback loop. I always feel smarter after reading these kinds of papers!

Evan Gordon@gordonneuro.bsky.social · last yr.

We have argued that the brain’s Action Mode Network controls functions required for goal-directed behavior. www.nature.com/articles/s41... Now, in new work, we show that AMN contains distinct subnetworks for making decisions, implementing actions, and processing feedback. doi.org/10.1073/pnas...

Fantastic work from @drdamienfair.bsky.social's using the latest in precision neuroimaging and neuromodulation to untangle the mechanisms of chronic pain!

Damien Fair@drdamienfair.bsky.social · last yr.

Alert!!!! “An Action Networks Model for Pain” We propose a new model for chronic pain — and highlight two functionally connected cortical networks that could revolutionize how we treat it. 👉 thread below 🧵 osf.io/preprints/ps...

It's not surprising to see that cutting off funding disrupts science and impacts its novelty, but I think it's important that this is documented and shared 🧪 . For more see the news coverage in @nature.com www.nature.com/articles/d41...

Renewal of NIH grants linked to more innovative results, study finds

Survey of hundreds of scientists’ work suggests that cutting off funding disrupts focus and reduces the novelty of research.

nature.com

My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our preprint!

Had a great time speaking with Sydney about our most recent paper out now in @natcomms.nature.com @macwoodburn.bsky.social . Paper link here: rdcu.be/ehbOy

The human brainstem’s red nucleus was upgraded to support goal-directed action

Nature Communications - The authors find the human red nucleus is functionally connected with action and motivated behavior networks, instead of motor-effector networks. They argue the red nucleus...

rdcu.be

Cedric Boeckx@cedricboeckx.bsky.social · last yr.

Happy to read @sydneywyatt.bsky.social’s piece on the recent study by @samkrimmelneuro.bsky.social @ndosenbach.bsky.social @gordonneuro.bsky.social re: the human red nucleus I was glad to discuss this great work with Sydney @thetransmitter.bsky.social www.thetransmitter.org/brain-imagin...

The brainstem’s red nucleus is an evolutionarily old structure that emerged as animals began to use limbs for walking, but its function in humans reaches beyond motor control, a new study suggests. By @sydneywyatt.bsky.social #neuroskyence www.thetransmitter.org/brain-imagin...

‘Old’ brainstem structure evolved beyond basic motor control

The human red nucleus may also help coordinate action, reward and motivated behavior, a new study suggests.

thetransmitter.org

It turns out the brain🧠is silently🤫working when your arm is in a cast. 🩼 🚧 Plastic changes occur, and revert again when the cast is removed … not just in cortex.

It's shocking how little is known about the brainstem red nucleus. In our new paper “The human brainstem’s red nucleus was upgraded to support goal-directed action” out now in @naturecomms.bsky.social we show that current thinking on the red nucleus is in need of a serious upgrade. rdcu.be/ehbOy

The brain’s action-mode network — a Perspective by Nico U. F. Dosenbach, Marcus E. Raichle & Evan M. Gordon @ndosenbach.bsky.social @gordonneuro.bsky.social www.nature.com/articles/s41...

The brain’s action-mode network - Nature Reviews Neuroscience

The brain enters an action-mode of function during goal-directed behaviour. In this Perspective, Dosenbach, Raiche and Gordon describe “action-mode” as an informative functional label that reduce...

nature.com

The brain’s action-mode is created by a dedicated action-mode network (AMN) rdcu.be/d5odm. In the brain’s mode continuum, AMN sits opposite DMN’s default-mode, as yin-yang. AMN might be key in pain, apathy, Parkinson’s. New @natrevneurosci.bsky.social w/ Marc Raichle & @gordonneuro.bsky.social 🧵 ⬇️

Is it critical to stimulate @ndosenbach.bsky.social's SCAN and CON networks for clinical improvements of Tourette's patients that undergo DBS? Carlos Baldermann says yes in a cool new paper out in @natureportfolio.bsky.social comms today! www.nature.com/articles/s41...