Benjamin Werner

@benjaminwerner.bsky.social

Es irrt der Mensch, solang er strebt. Group Leader at Barts Cancer Institute in London. Working on somatic evolution, ecDNA, clonal haematopoiesis… https://www.bartscancer.london/staff/dr-benjamin-werner/ Contact: b.werner@qmul.ac.uk

🧬 New preprint on coral somatic evolution! We compare the robust coral Orbicella faveolata with the complex coral Acropora palmata. 80x whole genome sequencing shows that O. faveolata has high fixation of somatic variants in older interior polyps consistent with a segregated germline.

doi.org

Published today in the Special Issue of Cell to mark this 25th anniversary, it is my honor to contribute in a review article to discuss how ecDNA could contribute to the established Cancer Hallmarks, especially its role in genome instability and mutation: www.cell.com/cell/fulltex...

A recipe for chaos: Extrachromosomal DNA and the hallmarks of cancer

When oncogenic genetic elements untether from chromosomes and no longer follow Mendelian inheritance, genomic chaos and accelerated evolution ensues. In this review, Wong et al. discuss the mechanisti...

cell.com

I'm thrilled to start my first bluesky post by highlighting the review paper Hyerim and I have been working really hard together - published just yesterday on Nature Reviews Drug Discovery. In this review, we outlined the latest ecDNA biology and corresponding therapeutic vulnerabilities [1/2] -

Nature Reviews Drug Discovery@natrevdrugdiscov.nature.com · 6mo ago

Targeting extrachromosomal DNA in human cancers www.nature.com/articles/s41... rdcu.be/e2kVS This new Review discusses ecDNA biology, challenges faced by current therapeutic and detection approaches and discoveries that highlight emerging therapeutic vulnerabilities