Pleased to share results from the CAcTUS Phase II trial of ctDNA-guided therapy in BRAF-mutant advanced melanoma are now published! 🌵🧬 CAcTUS is the first melanoma trial to adapt treatment based on ctDNA testing. Read: www.nature.com/articles/s41...

How do cells lining our epithelium evolve over a lifetime? 🧬 We built PHYFUM, a new Bayesian phylogenetic method to reconstruct the evolutionary history of normal tissue using Fluctuating Methylation. Here's what we found 👇 #CancerEvolution doi.org/10.64898/202...

Trevor Graham@trevorgraham.bsky.social · 3mo ago

In colon, stem cells divide & so do the crypts they reside in: a multi-level evolutionary process. D Mallo, P Bousquets @heathergrant.bsky.social @calumgabbutt.bsky.social have made "PhyPhum" to lineage trace somatic evolution in human glandular tissues www.biorxiv.org/content/10.6... @icr.ac.uk

In colon, stem cells divide & so do the crypts they reside in: a multi-level evolutionary process. D Mallo, P Bousquets @heathergrant.bsky.social @calumgabbutt.bsky.social have made "PhyPhum" to lineage trace somatic evolution in human glandular tissues www.biorxiv.org/content/10.6... @icr.ac.uk

Cases of bowel cancer in young adults are increasing at an alarming rate: there are too many stories like Bradley's, a young man who died from bowel cancer in his early twenties. @icr.ac.uk are fundraising so we can lead more research to prevent and better treat bowel cancer at all ages.

The Institute of Cancer Research@icr.ac.uk · 4mo ago

Today we launch our appeal to give everyone with bowel cancer the hope of a cure. Our world-class scientists are pushing the boundaries of research to shape a future in which bowel cancer is more preventable, predictable and treatable. Please support us today: www.icr.ac.uk/support-us/o...

If you work on quantitative cancer genomics, please consider submitting an abstract for our next "Cancer Population Genetics Club" #CANPOP meeting hosted @icr.ac.uk on 15 June 2026. CANPOP is free to attend. Registration & abstract submission here: docs.google.com/forms/d/e/1F...

New preprint: evolution of cross-resistance between two cancer drugs inferred from lineage barcoding data from single drug exposures. Removes need for complex combinatorial exposure experiments. Another tour de force from brilliant Freddie Whiting @icr.ac.uk www.biorxiv.org/content/10.6...

🔥🔥🔥💥💥💥🌶️🌶️🌶️ Hottest new lab in town, led by the exceptional @calumgabbutt.bsky.social, is recruiting it's first #PhD student. If you love #maths and somatic #evolution it could be your dream come true! 🌶️🌶️🌶️💥💥💥🔥🔥🔥

Calum Gabbutt@calumgabbutt.bsky.social · 6mo ago

If you’re interested in machine learning and mathematical modelling, we’re recruiting a PhD student to develop new methods for studying cancer evolution at @imperialimmuno.bsky.social www.findaphd.com/phds/project...

Is artificial general intelligence (AGI) already here? A thoughtful & compelling case: www.nature.com/articles/d41... "General intelligence can...emerge from simple learning rules applied at scale to patterns latent in human language: patterns [that] encode much of the structure of reality itself"

Does AI already have human-level intelligence? The evidence is clear

The vision of human-level machine intelligence laid out by Alan Turing in the 1950s is now a reality. Eyes unclouded by dread or hype will help us to prepare for what comes next.

nature.com

Open postdoc position in our lab @icr.ac.uk to develop a cfDNA test for #early detection of colorectal #cancer in inflammatory bowel disease #IBD: jobs.icr.ac.uk/vacancies/14... It's bench-to-bedside research, translating biology of pre-cancer evolution. Funded by @bowelcanceruk.bsky.social

Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs in Sutton | The Institute of Cancer Research

View details and apply for this Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Durati...

jobs.icr.ac.uk

Are you fascinated by cancer biology and also ❤️ 💻 ? Feel like this ->😻<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...

Data Scientist in Sutton | The Institute of Cancer Research

View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 - £53,500 (Salary appointment dependent on experience ) Reporting to: P...

jobs.icr.ac.uk

A big thank you to @bowelcanceruk.bsky.social and all their wonderful supporters for funding our research that aims to develop a blood test to predict bowel #cancer risk for people with inflammatory bowel disease #IBD. www.bowelcanceruk.org.uk/research/our... @icr.ac.uk

A new test to predict which people with inflammatory bowel disease will get bowel cancer

Dr Baker and Professor Graham are developing a non-invasive way to predict bowel cancer risk in people who have inflammatory bowel disease.

bowelcanceruk.org.uk

With the start of our new study trying to find causes of bowel cancer in young people hitting the headlines today: www.bbc.co.uk/news/article... I'm so glad to see bold efforts to raise awareness, like this giant 5x3m poster on the Croydon station platform I pass by on my to the lab each day

Cool new paper from @bloodgenes.bsky.social in @science.org. A common non-coding germline variant protects against clonal haem (CHIP) by modifying RNA regulatory networks. Wonder if CHIP protection is a tradeoff though - presumably some impact on immunity...? www.science.org/doi/10.1126/...

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation

Somatic mutations that increase the fitness of hematopoietic stem cells (HSCs) drive their expansion in clonal hematopoiesis (CH) and predispose individuals to blood cancers. Population variation in t...

science.org

All I want for xmas is... combined cell segmentation and phenotyping with high accuracy from whole slide histology images with #Classpose (semantic segmentation). www.biorxiv.org/content/10.6... From the inimitable @sohmandal.bsky.social @icr.ac.uk

Classpose: foundation model-driven whole slide image-scale cell phenotyping in H&amp;E

Cell segmentation and phenotyping in histopathology samples are essential techniques applied across diagnostic and research workflows. However, annotation by human experts requires significant time an...

biorxiv.org

Huge congratulations to Fran on being awarded the ERC Consolidator Grant! 🎉 Such a well-deserved recognition of an outstanding trajectory and a truly creative, exciting proposal on T-cell clonal hematopoiesis. Can’t wait to see the discoveries that come out of this project. So proud of you! 👏✨

Vall d’Hebron Institute of Oncology@vhio.bsky.social · 8mo ago

👏 Congratulations to Francisco Martínez Jiménez‼️ The head of the Computational Immunogenomics Group at #VHIO has been awarded an @erc.europa.eu Consolidator Grant to uncover new immunotherapy strategies built on expanded T-cell clones. ➡️ https://linke.to/ERCFranMVHIO #ERCCoG @cerca.cat

We held the first #CANPOP symposium today (cancer population genetics club) @icr.ac.uk. 6 excellent & didactic talks, all applying mathematical #popgen theory to dissect somatic evolutionary dynamics: spanning the full range of pre-cancer, metastasis through to 6000 year old transmissible cancer...

First paper from the exceptional Marco Bezzi, group leader in our @cec-icr.bsky.social: a disease-matched syngeneic mouse modelling platform for prostate cancer evolution. Many results here, highlighted is MYC/MAPK driving castration resistance & remodelling tumour microenvrn Congrats! @icr.ac.uk

ProMPt: A modular preclinical platform for functional modelling of prostate cancer heterogeneity and therapeutic vulnerabilities

Prostate cancer progression is driven by heterogenous genetic, phenotypic, and microenvironmental programs that remain challenging to model experimentally. Existing systems such as genetically enginee...

biorxiv.org

Fantastic opportunity from @turajliclab.bsky.social! 🚀 The CanDy Lab is recruiting an Associate Scientist to drive cutting-edge cancer research across @cruk-mi.bsky.social and @crick.ac.uk. A rare chance to lead, grow, and shape high-impact science 👇 www.cruk.manchester.ac.uk/career/mi-25...

MI/25/63 Associate Scientist | Cancer Research UK Manchester Institute

We are seeking a highly motivated and accomplished Associate Scientist to help lead and shape the programme. You will act as an operational deputy to Professor Samra Turajlic, helping to bridge activi...

cruk.manchester.ac.uk

@kevinmonahan.bsky.social & I have an open clinical #PhD position between @stmarkshospital.bsky.social and @icr.ac.uk If you're interested in the biology of pre-cancer in the bowel & want to translate biology for cancer prevention this one could be for you... funded by the brilliant #40tude

Kevin Monahan@kevinmonahan.bsky.social · 9mo ago

We are looking for our new Tom Smith Clinical Research Fellow in #LynchSyndrome and Early Onset ColorectalCancer with @trevorgraham.bsky.social in translational science … thanks to 40tude curing colon cancer for supporting this fellowship - get in touch! @stmarksgenomics.bsky.social @icr.ac.uk

Calling cancer data scientists! 📊 💽 🧮 We have a number of open positions in our core facility @icr.ac.uk These are bioinformatician staff scientist like roles to work on exciting single cell, spatial & other genomics data from across our Institute. A PhD is required. jobs.icr.ac.uk/vacancies/13...

Data Scientist in Sutton | The Institute of Cancer Research

View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £53,500 (Dependent on experience ) Reporting to: Professor Trevor Gra...

jobs.icr.ac.uk

New @natgenet.nature.com paper from the brilliant @eszterlakatos.bsky.social presents evidence that chromatin alterations disrupt antigen presentation & neoantigens in colorectal cancer. Also that immune escape is part of the "Big Bang", at the outset of CRC growth. www.nature.com/articles/s41...

Epigenetically driven and early immune evasion in colorectal cancer evolution - Nature Genetics

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

nature.com

Congratulations Alvaro! And your exciting papers are following...

Udai Banerji@udaibanerji.bsky.social · 9mo ago

PhD convocation ceremony at @icr.ac.uk with DrDr Alvaro Graces. His thesis entitled Clonal Dynamics and evolutionary pathways in high grade serous ovarian cancer under therapeutic pressure siggests our current use of chemotherapy can be better optimised. @trevorgraham.bsky.social

Ouse Valley Viaduct, Sussex, UK

🚨🚨🚨 Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program. If you're excited about evolution, genomics and biomedical research, this is your DN! 😃 Further info: www.evomg-dn.eu and 👇

We have two fantastically well-funded #PhD studentships available through the @evomg-dn.bsky.social #EU doctoral network (led by brilliant @mirimiam.bsky.social, @crg.eu). These enable students to move to the UK and come and work with us @icr.ac.uk to exploit #cancer #evolution for patient benefit.

Big, beautiful trees!! SMART-PTA for whole-genome+transcriptome on thousand of single cells from the normal human esophagus 🤯 Massively scaling up the power of scWGS to build deep phylogenies and chart somatic evolution from birth throughout life. www.biorxiv.org/content/10.1...

Great flash talks from Anton Patrikeev (HPV evolution in head and neck cancer) and Florian Gabel (resistance evolution in prostate cancer) both from our @cec-icr.bsky.social @icr.ac.uk #CrickCancerConf

Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life. www.nature.com/articles/s41...

Here's @calumgabbutt.bsky.social's nice thread on our #EVOFLUx paper in @nature.com that uses fluctuating methylation to track cancer evolution

Calum Gabbutt@calumgabbutt.bsky.social · 11mo ago

Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7) rdcu.be/eFrrc

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

nature.com