Berkeley Policy Institute

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The Berkeley Policy Institute (BPI, formerly BRG Institute) is an independent nonprofit working to advance knowledge on policy and management through research, publication, and public engagement. BPI is not affiliated with the University of California.

New article on MNEs & AI “Orchestration Theory of the Multinational Enterprise in Digital Platform and AI Ecosystems," by David Teece and Chris Pitelis, is freely available online in Management International Review via open access. doi.org/10.1007/s115... #DigitalPlatform #AI #MNE

Orchestration Theory of the Multinational Enterprise in Digital Platform and AI Ecosystems - Management International Review

The emergence of digital platforms, business ecosystems, and artificial intelligence (AI) is transforming the nature of multinational enterprise (MNE) activity and challenging established theories of international business. While internalization theory has provided a powerful explanation for the existence and boundaries of the MNE through its focus on market imperfections, transaction costs, and governance choices, its explanatory power is increasingly constrained in environments characterized by ecosystem-based value creation, distributed innovation, and technologically mediated forms of control. Building on earlier work by Pitelis and Teece, this paper advances orchestration theory as a broader framework for understanding the contemporary MNE. We argue that modern MNEs are best viewed not simply as organizations that internalize transactions, but as focal firms that orchestrate globally distributed systems of resources, capabilities, partners, and complementary assets. Orchestration encompasses the creation, co-creation, and capture of value through the deployment of dynamic capabilities and the management of complementarities and co-dependencies across organizational and national boundaries. The digital platform and AI era further reinforces the importance of orchestration as control increasingly derives from technological architectures, data flows, ecosystem positioning, and access to critical complementary assets rather than ownership alone. By integrating insights from internalization theory, dynamic capabilities, and ecosystem research, the paper proposes a reconceptualization of the MNE that better reflects the realities of contemporary international business and provides a foundation for future theoretical development.

doi.org

In a July 2026 podcast episode, Dr. Bo Heiden discusses the critical roles of patenting for biopharmaceuticals, and what can go wrong when lawmakers and courts oversimplify innovation trade-offs. Find out more, and watch or listen to the full conversation: www.aurorapatents.com/blog/the-bio...

The Biotech Bargain

Startups have a unique set of patent strategy needs - so let this blog be a resource to you as you embark on your patent strategy journey.

aurorapatents.com

Op-ed by Prof. Kristina Acri -- "Treatment for millions of Americans at stake in ‘skinny label’ Supreme Court case" Prof. Acri gives an overview of Hikma Pharmaceuticals USA Inc. v. Amarin Pharma, Inc., and the potential implications for innovation. www.washingtonexaminer.com/op-eds/45885...

Treatment for millions at stake in 'skinny label' Supreme Court case

The Hikma Pharmaceuticals USA Inc. v. Amarin Pharma, Inc. ruling could have a major effect on incentives to invest in research for FDA‑approved medicines.

washingtonexaminer.com

Does evidence support the #pharmaceutical evergreening narrative? The research points to a dynamic innovation process in which incremental improvements to existing medicines continue alongside eventual generic entry. Read the article by Prof. Erika Lietzan here: papers.ssrn.com/sol3/papers....

Evergreening's Empirical Chasm

For more than two decades, policymakers have been told that pharmaceutical innovators companies engage in a practice that is called, disparagingly, “evergreenin

papers.ssrn.com

Dynamic Universities: Strategic Leadership for Higher Education's Turbulent Future In a CMR Insights post, Prof. David Teece and Prof. Sohvi Heaton explore why and how university leaders must adapt in the current era for institutional viability and resilience. cmr.berkeley.edu/2026/05/dyna...

Dynamic Universities: Strategic Leadership for Higher Education’s Turbulent Future

Long-term institutional vitality depends on structured sensing, disciplined resource reallocation, and intentional organizational transformation.

cmr.berkeley.edu

New working paper from the Eira Initiative "Methodological Concerns and a Lack of Evidence for Reforming Regulatory Exclusivities for Pharmaceuticals" By Dr. Kristina M.L. Acri, née Lybecker, forthcoming in Nature Biotechnology eirainitiative.org/publications/

Publications - Eira Initiative

Publications Nature Biotechnology ~ Matters Arising: Methodological Concerns and a Lack of Evidence for Reforming Regulatory Exclusivities for Pharmaceuticals By Prof. Kristina Acri, Colorado College ...

eirainitiative.org