Falk Hildebrand

@bioinf.bsky.social

Bioinformatician, Quadram & Earlham Institute, Norwich, loves when programs break .. not

At 14.45 BST Anthony Duncan will present a new tool developed to uncover biologically meaningful patterns in biological datasets. The Python tool - cvaNMF - aims to describe samples from complex biological communities as a mixture of a small number of underlying signatures. @bioinf.bsky.social

Detecting signatures underlying the composition of biological data

Abstract. Biological compositional data is inherently multidimensional and therefore difficult to visualize and interpret. To allow for the automatic decom

academic.oup.com

The importance of sharing data and equivalizing sampling efforts of microbiome research across continents by @raeslab.org and colleagues: link.springer.com/article/10.1... Well spoken, let's all put this into action now!

Toward ethical human microbiome research: improving health through radical interdisciplinary and intercultural co-laboration - Microbiome

As human microbiome research is globalizing, it raises ethical concerns regarding the European and North American dominance in the field, which may reproduce a colonial bias and perpetuate inequities in global health research and outcomes. We suggest disentangling this ethical quandary into three main concerns: 1) scientific bias toward European and North American populations; 2) limited meaningful community inclusion, participation, and ownership, and 3) scant significant inclusion of diverse global researchers. We then formulate three recommendations for their resolution, deploying co-laboration—joint labor of diverse partners in generating synergies between diverse disciplines, cultures, and knowledges around shared concerns—and co-laborative science—a form of citizen science based on such synergies between diverse partners—to guide meaningful inclusive, participatory, and ethical human microbiome research. To conclude, we promote a programmatic list for putting co-laborative ethical science into practice, benefiting global communities, individuals, and researchers alike and decolonizing and improving health worldwide.

link.springer.com

Led by Anthony Duncan, and after much hard work, we have now published an Enterosignature follow-up paper: cvaNMF academic.oup.com/nar/article/... This work represents a generalization of the Enterosignature (ES) framework e.g. discovering ES disease associations, and describe "Terrasignatures" 👇👇👇

Detecting signatures underlying the composition of biological data

Abstract. Biological compositional data is inherently multidimensional and therefore difficult to visualize and interpret. To allow for the automatic decom

academic.oup.com

PhD opportunity: Exploring the western gut microbiome and how these transfer between family members (2nd Dec 25 deadline). www.uea.ac.uk/course/phd-d... This bioinformatic-project will teach high-resolution metagenomics, population genetics, mobile DNA and about bacterial species theory. Please RT

PhD PhD Opportunity: Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome (HILDEBRAND_Q26DTP) 2026/27 | UEA

PhD PhD Opportunity: Evolutionary and Ecological Impact of the Western Lifestyle on the Gut Microbiome (HILDEBRAND_Q26DTP) 2026/27 | UEA

uea.ac.uk

🆕 New project explores potential of soil microbes to achieve UK net zero goals Providing expertise in cutting edge methodologies for studying microbes, @bioinf.bsky.social and Dr Chris Quince, Group Leaders at the Quadram Institute & Earlham Institute, will together explore key research questions.

New project explores potential of soil microbes to achieve UK net zero goals - Quadram Institute

Researchers are combining the latest science in climate forecasting and soil science to understand how land use management could enable soil carbon storage

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