Vázquez López Lab
@biometalusc.bsky.social
Research group of Miguel Vázquez López. Full Professor of Inorganic Chemistry at Universidade de Santiago de Compostela and PI at CiQUS (Spain). Supramolecular Chemistry & Chemical Biology 🇪🇺 Website: vzlab.carrd.co IG: @biometalusc Linkedin: mvazquezlopez
Very happy to have shared our latest advances in the control of 3WJ recognition at @ismsc2026.bsky.social in Bordeaux. Congratulations to the organizers for a conference that was a real success even in the middle of an intense heat wave. #SupramolecularChemistry #ChemicalBiology #ISMSC2026
Very happy to have contributed to the symposium “Metallo-supramolecular chemistry meets Biology” at ICCC2026 in Odense, Denmark. Many thanks to Mike Hannon and Valerie Pierre for the invitation and for organizing such a stimulating symposium. #SupramolecularChemistry #ChemicalBiology
🎓 Huge congratulations to Dr. Axel Sarmiento Fuentes on successfully defending his doctoral thesis! 🥂 📘 “Peptide and Supramolecular Engineering for Delivery and Molecular Recognition” Well done, Áxel — we’re proud of you and excited to see where your next chapter leads! #FondosEuropeos
Many thanks to Dr. Andrew Kellett for his visit to #CiQUS and for sharing his latest research on “Recent Advances in Artificial Gene-Editing and DNA-Targeted Metallodrug Design.” It was a real pleasure to host you and learn from your insightful talk. #RedeCIGUS #FondosEuropeos
We had the pleasure of hosting @akellett.bsky.social (@dublincityuni.bsky.social) at @ciqus.bsky.social for a great lecture on his latest advances in metallodrugs and artificial gene editing. An inspiring visit that strengthens our scientific collaboration and friendship. #Metallodrugs #ChemSky
We’re excited to host Prof. Andrew Kellett (DCU) @akellett.bsky.social next Friday 24th at @ciqus.bsky.social (11:00 a.m.) for a talk on “Recent Advances in Artificial Gene Editing and DNA-Targeted Metallodrug Design” #ChemBio #ChemSky #DNA #Metallodrugs
#CiQUSintheMedia 🗞 | Un sistema molecular con potencial para recoñecer dianas do ADN asociadas ao cancro: A investigación de Miguel Vázquez, destacada nel Correo Gallego → www.elcorreogallego.es/santiago/202... #FondosEuropeos #RedeCIGUS
El CiQUS desarrolla una molécula con potencial para aplicarse en nuevas terapias contra el cáncer
El trabajo fue liderado por el catedrático de la USC Miguel Vázquez López
elcorreogallego.es
Last Sunday at noon, @tvgalicia.bsky.social Telexornal featured a short news piece on our recent @jacs.acspublications.org article (also highlighted as a cover). #DNAjunctions @ciqus.bsky.social @usc.gal Here is the link to it: www.g24.gal/-/un-achado-...
Un achado realizado en Galicia e por galegos pode facilitar a loita contra o cancro - G24
A peculiaridade da descuberta é a súa capacidade de empregala no espazo e no momento máis eficaces
g24.gal
Thrilled to announce our new National Project funded by the Agencia Estatal de Investigación and the Ministerio de Ciencia, Innovación y Universidades, focused on #CancerResearch #Metallopeptides #DNAJunctions #ChemicalBiology #SupramolecularChemistry
Agencia Estatal de Investigación@ageinves.bsky.social · last yr.Publicamos la Propuesta de Resolución Provisional de la convocatoria Proyectos Generación de Conocimiento 2024 (#PID2024). ✅ Dotación histórica de 667M de euros y 7.190 solicitudes. 👉 www.aei.gob.es/noticias/propuesta-resolucion-provisional-convocatoria-proyectos-generacion-conocimiento-2024
Albariño, fideuá & the beach🍷🥘 🏖️ with some friends from @ciqus.bsky.social @glowsticks.bsky.social @biometalusc.bsky.social @diegopena.bsky.social @montenegrolabo.bsky.social
🔥 New research from CiQUS makes the cover of Journal of the American Chemical Society (JACS): chiral helical polymers meet helicates and chart their path to DNA three-way junctions (3WJ). 🧪 Full story: www.usc.es/ciqus/en/new... #FondosEuropeos #RedeCIGUS
A molecular system with potential to target DNA structures associated with cancer
During DNA replication, the classic double helix can temporarily rearrange into an alternative structure known as a DNA three-way junction (3WJ). These configurations form a well-defined central
usc.es
🎨 Our JACS Supplementary Cover is out! A supramolecular story of fibers, peptide helicates, and DNA three-way junctions… 👉 pubs.acs.org/toc/jacsat/1... #DNAjunction #MyACSCover #ChemSky #SupramolecularChem @acs.org @pubs.acs.org @jacs.acspublications.org
Big news! 🚀 Our new paper is out in JACS! 👉 pubs.acs.org/doi/10.1021/... “Unlocking a Biological Interface of Chiral Supramolecular Helical Polymers” #DNAjunction #SupramolecularChem #ChemSky @acs.org @pubs.acs.org @jacs.acspublications.org
Unlocking a Biological Interface of Chiral Supramolecular Helical Polymers
Here we report a C3-symmetric metal-binding tripeptide, BTMA-1, that self-assembles in water into either a chiral supramolecular helical polymer or a discrete CoII peptide helicate, depending on metal coordination. The CoII peptide helicate exhibits high affinity and selectivity toward DNA three-way junctions (3WJ), a class of noncanonical DNA structures with emerging biological relevance. Importantly, we demonstrate that the recognition process can be triggered dynamically by adding CoII ions to a dispersion of the supramolecular polymer, which acts as an inert precursor reservoir in physiological media. In this way, our strategy shows that chiral supramolecular helical polymers can form temporarily inactive aggregates that release discrete helicates for biomolecular recognition, such as 3WJ binding, upon metal ion coordination. Overall, this mechanism reveals a previously unexplored capability of this class of materials and offers a new approach for the design of responsive supramolecular systems for nucleic acid recognition and anticancer therapy.
pubs.acs.org
🎉 Honored to share that I’ve been appointed as a new board member of @aebin25.bsky.social at #BioCiudadReal25. Grateful for the trust and excited to contribute to the growth of our vibrant community of spanish bioinorganic chemists. #AEBIN #BioinorgChem #ChemSky
Something big is coming… Soon, we’ll be able to share a story of peptide helicates, helical polymers, and DNA junctions. Stay tuned 😉 #ChemSky #DNAJunctions #SupraChemSky #ChemBioSky
Call for Expressions of Interest – MSCA Postdocs 2025 Join my group at CiQUS to work on “Selective DNA Junction Binders for Targeted Anticancer Therapy”. Deadline: June 15 www.usc.es/ciqus/en/MSC... #MSCA #CiQUS #DNAJunctions #Postdoc #ChemSky #ChemBioSky
Can’t wait to travel to Pavia next month to see my friends. Honored to speak at the Università di Pavia about our latest work on peptide helicates and DNA three-way junctions. #DNAJunctions #ChemSky #ChemBioSky
The best of the best! The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others Thank you again for your participation!
A small gift for @christinecardin.bsky.social — a short video of the beautiful crystal she solved with Mark Searcey A bright fragment of science 🧬 onlinelibrary.wiley.com/doi/10.1002/... #IRN_NAC #ChemSky #DNAJunctions
Especially of course @dmonchaud.bsky.social for all the inspiration and perspiration to get to this point.
The first IRN on Nucleic Acid Junctions meeting couldn’t have gone any better. Brilliant science, inspiring people, and a perfect atmosphere. Huge thanks to @dmonchaud.bsky.social for making it happen #IMAJ1 #ChemSky #DNAjunctions
David Monchaud@dmonchaud.bsky.social · last yr.Thank you, Miguel! It was great to have you all here in Paris. It was our first meeting, but it was so exciting and promising! I'm eager to repeat this beautiful experience next year, certainly in the UK! Stay tuned! #DNA #DNAjunction #iMAJ #IRN
One of the many great outcomes of the first IRN on Nucleic Acid Junctions meeting @hannongroup.bsky.social is now active on Bluesky — great to have you here, Mike ;) #IMAJ1 #ChemSky #DNAjunctions
Hannon research group@hannongroup.bsky.social · last yr.Vive les jonctions d'ADN! Fabulous scientific discussions in Paris with @biometalusc.bsky.social @sebastien-britton.bsky.social @christinecardin.bsky.social @dmonchaud.bsky.social @jlmergny.bsky.social @granzhan.bsky.social and Mark Searcey. Join us next year in UK for Edition 2 of this meeting!
Vive les jonctions d'ADN! Fabulous scientific discussions in Paris with @biometalusc.bsky.social @sebastien-britton.bsky.social @christinecardin.bsky.social @dmonchaud.bsky.social @jlmergny.bsky.social @granzhan.bsky.social and Mark Searcey. Join us next year in UK for Edition 2 of this meeting!
Vázquez López Lab@biometalusc.bsky.social · last yr.Great success at the first IRN on Nucleic Acid Junctions meeting — inspiring science, engaging discussions, and exciting prospects. Thanks to all, especially @dmonchaud.bsky.social for the leadership! @cnrs.fr @akellett.bsky.social @granzhan.bsky.social #IMAJ1 #ChemSky #DNAjunctions
Thank you, Miguel! It was great to have you all here in Paris. It was our first meeting, but it was so exciting and promising! I'm eager to repeat this beautiful experience next year, certainly in the UK! Stay tuned! #DNA #DNAjunction #iMAJ #IRN
Vázquez López Lab@biometalusc.bsky.social · last yr.Great success at the first IRN on Nucleic Acid Junctions meeting — inspiring science, engaging discussions, and exciting prospects. Thanks to all, especially @dmonchaud.bsky.social for the leadership! @cnrs.fr @akellett.bsky.social @granzhan.bsky.social #IMAJ1 #ChemSky #DNAjunctions
Great success at the first IRN on Nucleic Acid Junctions meeting — inspiring science, engaging discussions, and exciting prospects. Thanks to all, especially @dmonchaud.bsky.social for the leadership! @cnrs.fr @akellett.bsky.social @granzhan.bsky.social #IMAJ1 #ChemSky #DNAjunctions
Excited to speak at the 1st International Meeting on Nucleic Acid Junctions (IMAJ#1) in Paris, May 12–14, 2025. Grateful to be part of this great lineup. Thanks to Dr. David Monchaud and team! #IMAJ2025 #DNAjunctions #ChemSky
Inspiring morning at @ciqus.bsky.social with @lsalassa.bsky.social, who showed how flavin photocatalysis can unlock new paths for platinum-based cancer therapies. Brilliant chemistry 🧪, sharp vision 💡 #chemsky #chembiosky
