Sequential division of labor between PAXX and XLF drives NHEJ synaptic complex stability and maturation https://www.biorxiv.org/content/10.64898/2026.08.10.743781v1

Save the date! 2nd DNA Damage Response for Cancer Therapeutics returns 07 - 11 July 2027 in Portugal. Now a 5 day programme, bringing together leading experts in the field discussing their latest research - this is one you don't want to miss! Click here to sign up for updates: bit.ly/4xg9EBI

😱 " we generated 306,146 binder candidates covering 8,296 human proteins" The Human Bindome: A Proteome-scale Atlas of Designed Binder Candidates www.biorxiv.org/content/10.6... bindome.epfl.ch/static/index...

#ResultatScientifique🔎| Une découverte éclaire comment notre ADN est protégé grâce à deux protéines essentielles. Une avancée clé pour mieux comprendre certaines maladies et cancers ✍️ Patrick Calsou ▶️ buff.ly/McLDnCv 📕 @natcomms.nature.com

Excited to finally share our preprint on mapping the genetic interaction network of the DNA damage response with combinatorial knockout screens led by Sam Hayward, Alina Vaitsiankova, and Tomas Lama-Diaz! www.biorxiv.org/cgi/content/...

Mapping the genetic landscape of the DNA damage response with Cas12a-based combinatorial knockout screens

The DNA damage response (DDR) is a complex network of cellular pathways that ensures the faithful maintenance of our genomes upon a wide array of genomic insults. To elucidate the functional architect...

biorxiv.org

Exploiting HSD17B11-dependent dialkynylcarbinols cytotoxicity for facile CRISPR/Cas9-based gene inactivation https://www.biorxiv.org/content/10.64898/2026.05.13.724824v1

🧬 A new review article highlights 50 years of discoveries describing DNA’s many alternative forms which have trailblazed nucleic acid research. Read the full article at academic.oup.com/nar/article/... #DNAResearch #GenomeBiology #NucleicAcidsResearch #MolecularBiology #HistoryofDNA

Please join the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination in Roscoff, France. Deadline for abstract submission extended to May 20, 2026. cjm.sb-roscoff.fr/en/conferenc...

@sandraduharcourt.bsky.social · 4mo ago

The Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination is approaching. There are selected talk slots available. Abstract submission deadline: Tuesday, May 5, 2026.

600 directrices et directeurs d’unités du CNRS alertent sur les coupes budgétaires qu’ils qualifient de « rupture » : on leur demande de restituer des crédits DÉJÀ alloués aux laboratoires.

Our new review on NHEJ just came out on G&D genesdev.cshlp.org/cgi/content/... Highlight the 5 phases, and importantly, the 5 protein bridges that bring the 2 DNA ends together for NHEJ. Thank Dr. Geunil Yi, for generating the illustration for all structural models.

Excited to announce the upcoming Jacques Monod Conference on the mechanistic and evolutionary basis of programmed DNA elimination (Sept 21–25, 2026): cjm.sb-roscoff.fr/en/conferenc... Organized by @laurarossevo.bsky.social and myself.

Excited to announce: the EMBO Workshop: DNA damage response in cell physiology & diseases - 12–16 Oct 2026 - in stunning Sounio, Greece - fabulous speaker speaker lineup representing the cutting-edge of genome stability research: Abstract deadline: 17 May meetings.embo.org/event/26-dna... Join us!

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

Profiling the proteome-wide selectivity of diverse electrophiles - Nature Chemistry

Covalent inhibitors are powerful entities in drug discovery. Now the amino acid selectivity and reactivity of a diverse electrophile library have been assessed proteome-wide using an unbiased workflow...

nature.com

Réparer l’ADN cassé : comment les polymérases X peuvent-elles sauver nos cellules ? 🤝 @ipbstoulouse.bsky.social‬ ‪ @sebastien-britton.bsky.social‬ 👉 Lire l'article dans ‪ @natcomms.nature.com‬ buff.ly/n2gO2qZ

Réparer l’ADN cassé : comment les polymérases X sauvent nos cellules

L’ADN de nos cellules subit en permanence des lésions, dont la plus grave est la cassure simultanée des deux brins qui le comp

buff.ly

The Institute of Pharmacology and Structural Biology (IPBS) of Toulouse, France, is seeking for motivated postdoctoral researchers to apply for Marie Skłodowska-Curie and/or EMBO fellowships on specific projects (including one in the DDR team 😉 ) www.ipbs.fr/call-for-pos... Plse circulate or apply!

Call for Post-doctoral fellows - 2025 - IPBS-Toulouse

The Institute of Pharmacology and Structural Biology (IPBS) of Toulouse, France, is seeking motivated postdoctoral[…]

ipbs.fr

Really pleased to share this story from Amphista Therapeutics on the discovery and MoA of a potent and selective BRD9 "targeted glue" degrader. The compound also works in vivo and is orally bioavailable! Fantastic work from the team on a super fun project! www.biorxiv.org/content/10.1...

I'm honoured to speak at the upcoming Genome Instability & Cancer Conference, celebrating the legacy of Angelos Constantinou. His pioneering work transformed our understanding of DNA repair. Register now to join us near his home town in France in March! www.tribute2angelos.fr/page/home/

Hi DNA/RNA folks! With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie! 1st meeting next year (May 25) in Paris Contact me if interested

Hi Bluesky! New here and a bit surprised not to see a starter pack dedicated to Chemical Biology so.. here we go! go.bsky.app/DDpDuvo

ok, I tried to make a starter pack on genome stability/DNA replication/DNA repair etc. Sorry if I couldn't find someone, please nominate yourself and your colleagues in comments or DMs, looking forward to connecting with everyone! go.bsky.app/9jdDNxG

New updates to the upcoming DNA repair/Genome Stability conferences over 2024/2025. Please let me know if you have meetings to add: docs.google.com/spreadsheets...

DNA REPAIR/GENOME STABILITY CONFERENCES

docs.google.com