Interested in genetically encodable inhibitors of your favorite biomolecular condensate? Excited to announce our latest work, w/ Jibin Sadasivan, Gene-Wei Li, & Lindsay Case, on protein fragments as generalizable regulators of phase separation. (1/n) www.biorxiv.org/content/10.6...

If you're at #cellbio2025, @atmolines.bsky.social Hernan Garcia and I invite you to attend our Minisymposium “Physical Cell Biology from Molecules to Organisms” for incredible talks on epigenetic mechanical memory, viscoelasticity, cortical flows, morphogenesis, tissue wetting, size scaling, et al!

🚨 Link up with me at #Cellbio2025 ! 🚨 Excited to present the majority of my postdoc work in the Physical Cell Biology from Molecules to Organisms Minisymposium. Thanks to the organizers for putting together such an exciting session 🤩

Rikki Garner@rikkigarner.bsky.social · 8mo ago

If you're at #cellbio2025, @atmolines.bsky.social Hernan Garcia and I invite you to attend our Minisymposium “Physical Cell Biology from Molecules to Organisms” for incredible talks on epigenetic mechanical memory, viscoelasticity, cortical flows, morphogenesis, tissue wetting, size scaling, et al!

Super excited to share some of my work in such a great session at #cellbio2025!! If you’re at the meeting come on down, I’ll be talking about cell density and its influence on tissue fluidization during epithelial morphogenesis 🔬👨🏻‍🔬🪰

Rikki Garner@rikkigarner.bsky.social · 8mo ago

If you're at #cellbio2025, @atmolines.bsky.social Hernan Garcia and I invite you to attend our Minisymposium “Physical Cell Biology from Molecules to Organisms” for incredible talks on epigenetic mechanical memory, viscoelasticity, cortical flows, morphogenesis, tissue wetting, size scaling, et al!

Looking forward to seeing everyone at #cellbio2025! Excited to share new work from my postdoc to measure, model, and control the interplay of tissue fluidity and multicellular patterning in a living organism. Come see me at my talk or poster (details below), or DM me if you want to meet up!

Thrilled to contribute to this exciting work on protein binder design together w/ @hannes-stark.bsky.social , Felix Faltings, Regina Barzilay, Tommi Jaakkola, and co. We applied BoltzGen to design novel antimicrobial peptides targeting DNA gyrase based on inhibitory protein fragments. (1/n)

Hannes Stark@hannes-stark.bsky.social · 9mo ago

Excited to release BoltzGen which brings SOTA folding performance to binder design! The best part of this project is collaborating with a broad network of leading wetlabs that test BoltzGen at an unprecedented scale, showing success on many novel targets and pushing the model to its limits!

Happy to share that this work is now published in @biophysj.bsky.social! doi.org/10.1016/j.bp...

Rikki Garner@rikkigarner.bsky.social · last yr.

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...

So honored to be speaking today at the Stanford.Berkeley.UCSF Next Generation Faculty Symposium! Hope to see you there! (Zoom registration link below)

Polly Fordyce@pollyfordyce.bsky.social · 11mo ago

Incredibly excited for this year's iteration of the Next Generation Faculty Symposium on 9/10/25! This is a fantastic opportunity to hear 10 minute talks describing fantastic cutting-edge science from researchers preparing to launch a faculty search. Please register (link below) & forward widely :)

Friendly reminder that the deadline to submit an abstract for talk at #cellbio2025 is TOMORROW, Wednesday, September 3, 2025 at 9 PM ET! Please consider submitting to our minisymposia "Physical Cell Biology from Molecules to Organisms (more details in the repost)

Rikki Garner@rikkigarner.bsky.social · last yr.

Excited to announce our minisymp. “Physical Cell Biology from Molecules to Organisms” #CellBio2025 w/ Hernan Garcia and ‪@atmolines.bsky.social‬! Have an interesting story on how physical cell properties are controlled, coordinated across scales, or contribute to development and disease? (1/3)

Check out this exciting new minisymposium at ASCB!

Rikki Garner@rikkigarner.bsky.social · last yr.

Excited to announce our minisymp. “Physical Cell Biology from Molecules to Organisms” #CellBio2025 w/ Hernan Garcia and ‪@atmolines.bsky.social‬! Have an interesting story on how physical cell properties are controlled, coordinated across scales, or contribute to development and disease? (1/3)

Congratulations to Barbara Imperiali, the Class of 1922 Professor of Chemistry and Biology, who has been elected as a Fellow of the Royal Society, the United Kingdom’s national academy of sciences. chemistry.mit.edu/chemistry-ne...

The @berlowlab.bsky.social kicking off the next session at #PS39 If you missed his talk, Jake Simmons and Jamie Do of the Berlow lab will both be presenting posters at the afternoon session!

We found that cells use emergent collective memory—arising from simple chemical reactions—to outperform physical limits of detecting chemical gradients. Curious how? 1/n 8 min talk: www.youtube.com/watch?v=A7XH... bioRxiv: www.biorxiv.org/content/10.1... #biophysics #cellbiology

Local collective memory from ratiometric signaling outperforms cellular gradient sensing limits

YouTube video by Debraj Shubham Ghose

youtube.com

Excited to be at the @bostonbacteria.bsky.social‬ Meeting this year! I'll be a panelist at the AI in biology breakout session on Tuesday 6/10 after lunch, in Hall A -- together with ‪@microyunha.bsky.social‬ and M.S. Suryateja Jammalamadaka. Come join us for what should be a great discussion!

Whitehead Institute Member Yukiko Yamashita, who studies how genetic information is passed from parents to offspring, has been elected to the National Academy of Sciences. Full story on our website: wi.mit.edu/news/yukiko-...

So excited to see this live! Awesome work from @giannatbusch.bsky.social on the concept of population-based synergy—using cell-to-cell heterogeneity to uncover new therapeutic vulnerabilities!

Gianna T. Busch@giannatbusch.bsky.social · last yr.

Excited to share our new work on the distinct drug sensitivity profiles of heterogeneous therapy-resistant melanoma cells! @arjunraj.bsky.social www.biorxiv.org/content/10.1... (1/10)

Super excited to share a new preprint from our lab on design of small-molecule binding proteins using neural networks! The paper has a bit of everything. A new graph neural network, new design algorithms, and experimental validation. www.biorxiv.org/content/10.1... 🧵🧪

Zero-shot design of drug-binding proteins via neural selection-expansion

Computational design of molecular recognition remains challenging despite advances in deep learning. The design of proteins that bind to small molecules has been particularly difficult because it requ...

biorxiv.org

I'm the biggest fan of Rikki. Elegant physics. Breathtaking biology. If you're looking for a seminar speaker...she's a fantastic communicator. Congrats for the new work, @rikkigarner.bsky.social!

Rikki Garner@rikkigarner.bsky.social · last yr.

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...

Check out this extremely thought-provoking work on tissue fluidity, cell motility, and patterning from @rikkigarner.bsky.social! Certainly changes how I think about development...

Rikki Garner@rikkigarner.bsky.social · last yr.

In developing embryos, cells move a lot! Plenty of that movement is random. Is random cell mixing a feature or bug for tissue patterning? Turns out, it’s both! Excited to share the 1st preprint from my postdoc w/ Sean Megason @seanemcgeary.bsky.social and Allon Klein. 1/20 doi.org/10.1101/2025...

Also happy to share the @MITBiology news brief highlighting our @NIH-funded basic research which paves the way to systematically develop novel inhibitors and drugs, such as peptide-based antibiotics: biology.mit.edu/a-sum-of-the....

A sum of their parts

All biological function is dependent on how different proteins interact with each other. Protein-protein interactions facilitate everything from transcribing DNA and controlling cell division to highe...

biology.mit.edu

Andrew Savinov@biosavinov.bsky.social · last yr.

Happy to announce that our paper on systematically discovering peptides to inhibit protein-protein interactions in living cells is out now @pnas.org: www.pnas.org/doi/10.1073/.... @MITBiology @hhmi.bsky.social See thread on the updated preprint for details: x.com/bioSavinov/s...

Happy to announce that our paper on systematically discovering peptides to inhibit protein-protein interactions in living cells is out now @pnas.org: www.pnas.org/doi/10.1073/.... @MITBiology @hhmi.bsky.social See thread on the updated preprint for details: x.com/bioSavinov/s...

Researchers engineered Escherichia coli bacteria to express an enzyme derived from sea sponges, which polymerizes bioglass from silica, allowing the bacteria to self-assemble lenses that focus light into narrow, intense beams. In PNAS: www.pnas.org/doi/full/10....

Now updated! www.biorxiv.org/content/10.1...

Make-or-break prime editing for bacterial genome engineering

CRISPR-Cas9 has revolutionized genome engineering by allowing precise introductions of DNA double-strand breaks (DSBs). However, genome engineering in bacteria is still a complex, multi-step process r...

biorxiv.org

Axel Janssen@axeljanssen.bsky.social · 2y ago

🚨New work alarm🚨 Very happy to see this work out, together with Monica, @mvmazzuoli.bsky.social, Anne-Stephanie, Xue, and @jwveening.bsky.social. We developed make-or-break Prime Editing, through which we can make a wide variety of mutations. Read more on BioRxiv!

⚠️ Tag with Caution ⚠️ New preprint led by Kerstin Dörner in Maria Hondele’s lab with contributions from Fan Cao on our side on the effects of tagging with FPs and peptides on condensation and phase separation 🧪 TL/DR: It’s complicated See more: doi.org/10.1101/2024...

bioRxivpreprint@biorxivpreprint.bsky.social · 2y ago

Tag with Caution - How protein tagging influences the formation of condensates https://www.biorxiv.org/content/10.1101/2024.10.04.616694v1