Alex Bisson

@archaeon-alex.bsky.social

🇧🇷🇺🇸Evolutionary Cell Mechanobiology of Archaea. Associate Professor at Indiana University. Standing tall on the shoulders of tiny (salty) bugs. Lab Website: bissonlab.com

A call out to our former postdoc John Mallon (not in social media), who contributed to both device development and “biology” :). John evolved a salt-loving archaeon to love salt a bit less (2.6M down to 1.3M!). Cells recovered growth rate AND cell morphology. Congrats Phil, Sebastian, and John!

Sebastian S. Cocioba@atinygreencell.bsky.social · 4w ago

@breakliquid.bsky.social and I are delighted to say our OpenEVO preprint is finally live! An open source hand-made turbidostat that's modular, affordable, and made to be customized. Designed with love for the research community. Enjoy!!!💚 www.biorxiv.org/content/10.6...

1/🧵 Can transcription factor condensate formation be explained without phase separation? Our new preprint introduces SPARK, a simulation tool that reproduces condensate behavior (clustering, fusion, FRAP) from diffusion & binding kinetics alone. Movie: 60 sec FRAP sim www.biorxiv.org/content/10.6...

Thank you, we hope people use it to think about condensates in various systems! SPARK isn’t sequence-based but rather works by modulating kinetic parameters (diffusion coeff, binding probability, residence time etc.) which does affect properties like brightness and persistence of condensates (Fig 1)

The Bisson Lab at IU (bissonlab.com) is hiring makers/builders/engineers across all career stages to join our team in one of the most exciting and crazy projects I've set to work on. Candidates can email us: saltylab@iu.edu More info in the thread [1/3]

Can't miss this amazing study on the ribosome structure of the Haloferax archaeon 👏🏼👏🏼👏🏼!! Congrats to my good friend @diorgeps.bsky.social and all the other ppl involved!!

Diorge Souza@diorgeps.bsky.social · 5mo ago

A new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...

Another paper on a topic we never worked on before: a new ribosomal hibernation! Under the leadership of the super-postdoc Diorge, Davis Lab (ribo-cryoEM master), and @vikramalva.bsky.social (protein-evo whisperer), we identified AHA (not the song, but archaeal hibernation AMPKγ factor). (1/2)

Diorge Souza@diorgeps.bsky.social · 5mo ago

A new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...

Very cool work led by @diorgeps.bsky.social from the labs of @archaeon-alex.bsky.social & Joey Davis (MIT)! They solved the Haloferax volcanii ribosome and characterize AHA, a conserved archaeal hibernation factor. With several recent related preprints, it’s an exciting moment for the field!

Diorge Souza@diorgeps.bsky.social · 5mo ago

A new preprint from the @archaeon-alex.bsky.social and Joey Davis (MIT) labs! We solved the structure of the ribosome from the archaeon Haloferax volcanii and discovered a new highly conserved ribosome hibernation factor that we named AHA (AMPKγ–HPF from Archaea) 🧵⬇️ www.biorxiv.org/content/10.6...

Excited to share this new Preprint from our lab led by PhD Candidate Carl Stone (defending Tuesday). Here we present a framework for longitudinal rbTn-Seq and apply it to the Microbial extended growth curve to resolve the fitness seascape through growth, death, and long-term stationary phase!

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bioRxiv Evolutionary Biology@biorxiv-evobio.bsky.social · 6mo ago

Bayesian analysis of longitudinal RB-TnSeq resolves the fitness seascape in fluctuating environments https://www.biorxiv.org/content/10.64898/2026.02.11.703069v1

🚨 Alarm!!! 🚨 AI/ML course for microscopy image analysis!!! 🧐 In 2026 at Janelia (@hhmijanelia.bsky.social), no tuition, housing and meals provided! Isn’t that borderline unbelievable?!? 20 students, ~14 TAs and lecturers 🗓️ June 4-18 2026 ✍️ Jan 15 2026 ✍️ 🔁 pls!! www.janelia.org/you-janelia/...

Deep Learning for Microscopy Image Analysis

Topics The following will be covered extensively during lectures, exercises, and project work: Image denoising and restoration (fully supervised and self-supervised) Image translation (e.g.,

janelia.org

I am beyond excited to announce that the Bisson Lab has a new home!!! Starting January 2026, I will join the Biology Department at Indiana University Bloomington as Associate Professor with tenure. I am actively recruiting scientists across all levels. More in our website: bissonlab.com/join [1/4]

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I’ve been regularly volunteering at a food bank for about a year and please, if you want to help, consider donating cash. For $3, they can provide 15 meals and what they can do with the money you might spend on a few cans can be converted to vastly more in fresh fruit, vegetables, dairy, or meat.

"Electroboy" is my memoir about my battle with bipolar disorder and which is being made into a feature film with Timothee Chalamet. The book is out of print - I have h/c and p/b copies which I inscribe to you and ship overnight to you. The cost is $30 for a h/c and $20 for a p/c - send me a DM!

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This is one of my fav bac cell div papers. It's remarkable how much we've learned about cytokinesis in the past decade, and how much we still don't know. This paper harmonizes many of the disagreements in the field, like what limits construction rates (1/4)

Ethan Garner@fleshball.bsky.social · last yr.

I’m excited that the work by Diego Ramirez and Lei Yin is out, where they gained several key insights into what provides the force underlying bacterial cell division doi.org/10.1101/2025.... To divide, cells must first bend the membrane inward, a process that’s energetically expensive

It bears repeating that nearly the entire US enterprise in science and technology has been irreversibly gutted. This is shocking. All this loss has occurred without any real benefit to the average US citizen. Except we now have the biggest, best funded secret police force perhaps ever. Yay for us!

Trump doesn't seem to see that some people are still immune to his threats. Jack White criticized Trump's Oval Office decor. The White House then called White a "washed-up, has-been loser... masquerading as a real artist." And White, undeterred, posted an absolutely blistering takedown in response.

officialjackwhite
"Jack White is a washed up, has-been loser posting drivel on social media because he clearly has ample time on his hands due to his stalled career," wrote Cheung. "It's apparent he's been masquerading as a real artist, because he fails to appreciate, and quite frankly disrespects, the splendor and significance of the Oval Office inside of The People's House."--White House Communications Director Steven Cheung

Listen, I'm an artist and not a politician so I'm in no need to give my answer or opinion on
anything if I'm not inspired or compelled, but how funny that it wasn't me calling out trump's
blatant fascist manipulation of government, his gestapo ICE tactics, his racist remarks about
Latinos, Native Americans, etc. his ridiculous "wall" construction, his attacks on the disabled
his attempted coup and mob insurrection and destruction of the sacred halls of congress,
his disparaging sexist and pedophilic remarks about women, his obvious attempts at
distraction about being a close personal friend of Jeffrey Epstein and his inclusion in the
Epstein files, his ignorance of the dying children in Sudan, Gaza, and the Democratic
Republic of the Congo, his lack of empathy for military veterans and those struggling with
poverty, his attempts to dismantle healthcare, his obvious wimpy and pathetic kowtowing
to the dictators Putin and Kim Jong Un, his nazi like rallies, his attempts to sell merchandise
and products like Goya beans through the office of the President, his fake "gunshot to the ear"
that he showed no medical records or photographs of his constant, constant lying to the American people, etc. etc. No, it wasn't me calling out any of that, it was the fucking DECOR OF THE OVAL OFFICE remarks I made that got them to respond with insults.
How petty and pathetic and thin skinned could this administration get? Masquerading as a
real artist? Thank you for giving me my tombstone engraving! Well here's my opinion,
trump is masquerading as a human being.officialjackwhite
He's masquerading as a christian, as a leader, as a person with actual empathy.
He's been masquerading as a businessman for decades as nothing he's involved in
has prospered except by using other people's money to find loophole after loophole and grift after grift. His staff of professional liar toadies like Steven Cheung
and Karoline Leavitt have been covering up and masking his fascism as patriotism and
"ample time on
at golf than
helping ANYONE in the country. Improve. Anything. There
progress with him, only
smoke and mirrors and tax breaks for the ultra wealthy. So maga folk, enjoy your
concrete paving over of the rose garden, your 200 million dollar ballroom in the White House, and your gaudy ass gold spray painted trinkets from Home Depot, cause he ain't spending any
money agenda. on helping YOU unless you fit into his white supremascist country club rich idiot.
No intelligent person can defend this
low life fascist. This bankrupter of casinos. This failed seller of trump steaks, trump vodka,
trump water, etc. This man and his goon squad have failed upwards for decades and have
fleeced the American people over and over. This professional golf cheat, this grifter who
has hundreds of thousands of deaths from his inaction of the pandemic on his hands,
this man that the majority of the country somehow were fooled into supporting and
voting into office (through the flawed electoral college) and their love of reality
television stars. Being insulted by the actual White House that this particular conman
leads is a badge of honor to me, because anyone who trump supports and likes is a villain
who gives nothing to their fellow man, only takes what can benefit themselves.
And no I'm not a Democrat either, I'm a human being raised in Detroit, I'm an artist who's
owned his own businesses like his own upholstery shop and recording label since he
was 21 years old who has enough street sense to know when a 3 card monte dealer is a
cheap grifter and a thief.