What is the most appropriate platform for roasting a #bioinformatics colleague? You simply put them on BLAST

Important work! Generally we either think about specialized glycan binding proteins (lectins) or we don't think about glycans. Canner et al help us see the massive world proteins, 35-40%, that also bind glycans! Thanks Sam for bringing glycan-protein interactions into focus!

Samuel William Canner@swcanner.bsky.social · last yr.

I’m happy to announce my latest paper has been released as a preprint on BioRxiv: Predictions from Deep Learning Propose Substantial Protein-Carbohydrate Interplay. This paper was only able to happen thanks to both @jeffreyjgray.bsky.social and Dr. Ronald L Schnaar www.biorxiv.org/content/10.1...

#Medsky update: I've added label support to the following feeds: Family Medicine: bsky.app/profile/meds... Cardiology: bsky.app/profile/meds... Int Medicine: bsky.app/profile/meds... Nephrology: bsky.app/profile/meds... Gastro: bsky.app/profile/meds... Rheum: bsky.app/profile/meds...

Boltz-1: Open source (MIT license) protein + PPI + PLI structure prediction method performs on par with AlphaFold3 by Gabriel Corso, Barzilay et al. & Genesis Therapeutics Blog-post jclinic.mit.edu/boltz-1/ Technical report: t.co/px0spnTA0S Model and code: github.com/jwohlwend/boltz

Important numbers to know for the difficult years ahead. Also worth asking if the "next dollar" will yield similar returns. How much more would we need to invest in research to see less than a 250% return?

Sergiu P. Pasca@sergiuppasca.bsky.social · 2y ago

Research funded by NIH generated $2.46 in economic activity for every $1 of funding in 2023 [a total of $92.9 billion] www.fiercebiotech.com/research/rep...

My starter packs (1) handy list of all (blueskydirectory.com/starter-packs), ...

Starter Packs - Bluesky Directory

A curated collection of all things relating to the Blue Sky social media platform.

blueskydirectory.com

New bit of work from CCG, with our newest cellular framework - GlycoCarrier www.nature.com/articles/s41...

Mammalian cell-based production of glycans, glycopeptides and glycomodules - Nature Communications

Access to defined human glycans is crucial for biomedical research. Here, authors report Glycocarriers, a mammalian cell-based method for the sustainable and scalable production of O-, N-glycans, and ...

nature.com

A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses www.science.org/doi/full/10....

A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses

Profiling of ERV-reactive B-1 cells in mice reveals natural antibodies against terminal N-acetylglucosamine on multiple viral envelope proteins.

science.org

Download our database of 313 different postdoctoral fellowships. For each entry, we provide link to funder, description, amount, deadline, and eligibility criteria (e.g. citizenship). Download our database here: research.jhu.edu/rdt/funding-...

Partner and I got an icecream maker. Tldr, we think we can make some weird icecream with a bit of help from glycans! Will share if it's good or weird.

Reposting for continuity... I believe we discovered a comprehensive mapping from protein structure to glycan structure, a genetic encoding for specific glycans, and a new paradigm in extracellular biology. www.biorxiv.org/content/10.1...

go.bsky.app/CN9pS3u We are home!