Joost Snijder
@joostsnijder.bsky.social
a sort of scientist. viruses and antibodies. structure and biophysics. mass spec and cryoEM
How does an adenovirus transform from an immature particle into an infectious virus? See our new preprint for a closer look at how protease activity orchestrates structural changes that enable adenovirus maturation and infectivity. www.biorxiv.org/content/10.6...
bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 14h agoProtease-driven remodeling of stabilization networks during adenovirus assembly https://www.biorxiv.org/content/10.64898/2026.08.04.740336v1
Ontslag, huiszoekingen en jarenlange rechtszaken: dat hangt militairen boven het hoofd als ze misstanden aankaarten bij de krijgsmacht. Defensie belooft al twintig jaar om de behandeling van klokkenluiders te verbeteren, maar in de praktijk is er weinig tot niets veranderd. Hoe kan dat?
Klokkenluiders bij Defensie nog altijd vogelvrij
Het ministerie van Defensie kent een lange reeks aan klokkenluidersaffaires. Minstens zo lang is de rits onderzoeksrapporten en aanbevelingen, maar wat is er de afgelopen jaren nou wezenlijk veranderd...
ftm.nl
De wooncrisis lijkt iets van de laatste jaren, maar wie verder terug gaat in de tijd, komt tot een heel andere conclusie. Thomas Bollen spreekt met Buitenhof-presentator Maaike Schoon over waarom huizenprijzen blijven stijgen zonder dat er genoeg woningen bij komen. www.ftm.nl/artikelen/po...
Podcast | ‘Wij zijn allemaal speculanten’ – hoe de grond onder je huis een financieel product werd
In deze podcast spreekt Follow the Money-journalist Thomas Bollen verschillende gasten over het thema ‘geld’. In deze aflevering interviewt hij journalist en Buitenhof-presentator Maaike Schoon. In ha...
ftm.nl
Ebola may have been spreading for months in the DRC before anyone recognized it. A new reconstruction suggests the outbreak was already widespread in the gold-mining town of Mongbwalu by January. It wasn’t officially declared until 15 May. Why did no-one raise the alarm? My story for @science.org 🧪
EXCLUSIVE: Congo’s Ebola epidemic started at least 4 months before it was detected
A remote mining town gripped by fear saw hundreds of suspected cases before the government declared an outbreak, report says
science.org
New @talusbio.bsky.social #AI preprint just dropped 🚀 Meet Ptarmigan-1. It predicts which small molecules bind a protein, and which residues they hit, from sequence and 2D chemistry alone. No structures, no docking, no poses. www.biorxiv.org/content/10.6... Time for a 🧵 (1/13)
Structure-free, site-resolved contrastive learning extends small-molecule discovery beyond the reach of structure-based modeling
Virtual screening asks which molecules, among an enormous space of drug-like chemistry, are worth synthesizing and testing against a protein target. Most modern methods answer by building and scoring ...
biorxiv.org
We are excited to share two preprints reporting a mosquito-specific receptor for chikungunya virus and other alphaviruses! 🤩 www.biorxiv.org/content/10.6... www.biorxiv.org/content/10.6... @harvardmicro.bsky.social @harvardvirology.bsky.social @hhmi-science.bsky.social
Great to see this finally published! We describe channels at the poxvirus core wall involved in nucleic acid release. www.nature.com/articles/s41...
In situ structure of the poxvirus portal complex - Nature
Cryo-electron tomography uncovers the structure of a conserved hexameric ‘portal complex’ that spans the core wall in vaccinia virus, and shows how it is associated with viral functions such as a...
nature.com
One month left to apply (deadline August 31st)! 👇 #Virology #AcademicJobs #FacultyJobs #FacultyPosition #TenureTrack #GroupLeader
Daniel Hurdiss@danielhurdiss.bsky.social · last mo.We are looking for an Assistant or Associate Professor to join us at the @utrechtvirology.bsky.social. Interested in building an independent research programme in a collaborative #virology environment? Please take a look and share with anyone who might be a good fit! www.uu.nl/en/organisat...
Opinie met Renske Leijten over de datakluis bij belastingdienst - Overtredingen van grondwet, WOO en strafrecht (achterhoudenvoor parlementaire enquete) - Financien moet nu ophouden zichzelf te onderzoeken - OM, politie, Kamer aan zet Lees hieronder: www.trouw.nl/opinie/piete...
Pieter Omtzigt en Renske Leijten: Laat Financiën niet wegkomen met dit onderzoek naar de achtergehouden datakluis
De vondst van bewust achtergehouden documenten vormt een nieuwe ontmaskering na het toeslagenschandaal, schrijven oud-Kamerleden Pieter Omtzigt en Renske Leijten.
trouw.nl
Spijt is eigenlijk zonde van de tijd. Maar van mijn fout op 27 mei 2020 lig ik nog regelmatig wakker… Nieuwe column 👇🏽 open.substack.com/pub/nijman/p...
‘Door mijn fout werd iedereen beetje bij beetje gecorrumpeerd’
Over spijt, strafrecht en een datakluis
open.substack.com
Als het over de wooncrisis gaat, wordt vaak naar expats gewezen als schuldigen. Maar is het echt zo simpel? Buitenlandse kenniswerkers hebben dankzij hun belastingkorting extra geld en kunnen daarmee Nederlandse woningzoekers aftroeven. Maar dat effect blijkt landelijk verrassend klein. Hoe zit dat?
Expats zouden jouw woning afpakken, maar dat valt wel mee
Het populaire verhaal dat buitenlandse kenniswerkers de woningmarkt ontregelen, blijkt maar ten dele waar. Met het afschaffen van de belastingkorting voor expats los je de landelijke wooncrisis dan oo...
ftm.nl
102 new Ebola cases and 45 deaths reported by DRC over past 24 hours. For context: Many Ebola outbreaks in the past have remained small. These numbers mean the DRC has reported more cases overnight than were reported IN TOTAL during each of about two dozen smaller Ebola outbreaks. 🧪
Doneer jij wel eens bloed? 🩸 Dan krijg je daar niets voor terug. Maar de organisatie die het ontvangt, Sanquin, verkoopt het wél op de internationale markt. De bloedbank draait op belangeloosheid, maar in een wirwar van bv’s gaan honderden miljoenen euro’s om. www.ftm.nl/artikelen/jo...
Jouw belangeloos gedoneerde zak bloedplasma kan zomaar op de commerciële markt belanden
Bij de Nederlandse bloedbank Sanquin krijgen bloeddonoren een roze koek en een sleutelhanger. Het kan daarna zomaar zijn dat je bloedplasma belandt in een woud van commerciële bv’s, waar honderden mil...
ftm.nl
DRC's #Ebola case count continues to climb. As of 07/22, there have been 2,905 confirmed cases, 1,269 of them fatal. At this pace it may not be long before this outbreak surpasses the 2018-2020 North Kivu outbreak, the 2nd largest on record (3470 cases, 2287 of them fatal). insp.cd/sitrep-n069-...
NEJM.org@nejm.org · 2w agoAlpha-gal syndrome is an IgE-mediated delayed hypersensitivity to galactose-α-1,3-galactose (alpha-gal), a carbohydrate found in mammalian meat but absent from human tissue. The condition is initiated by exposure to alpha-gal through tick bites. Learn more: https://nej.md/4wIygTh
In new study led by @bdadonaite.bsky.social, we show many influenza HAs (H5, H7, H9, H1, H2, H3) can use avian or human MHC-II to enter cells. We then use novel combo of deep mutational scanning & cryoEM to define how H5 HA binds to avian MHC-II. Preprint: doi.org/10.64898/202...
Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly www.nature.com/articles/s41...
Direct lipid interactions control SARS-CoV-2 M protein conformational dynamics and virus assembly - Nature Communications
SARS-CoV-2 M protein binds the host lipid ceramide-1-phosphate, stabilizing its short conformation to organize viral structural proteins during assembly. Disrupting this interaction impairs virus-like...
nature.com
Important @nejm.org correspondence today. Investigators found that licensed Ebola vaccines generate cross-reactive binding antibody responses against Bundibugyo ebolavirus (BDBV) in humans. www.nejm.org/doi/full/10....
Excited to share our now published paper @cp-cell.bsky.social highlighting advances in modeling the evolution of protein-protein interactions with MSA Pairformer. Big thanks to Zhidian Zhang, Olivia Tang, @eunbelivable.bsky.social @milot.bsky.social @martinsteinegger.bsky.social and @sokrypton.org!
Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer
Protein language models have excelled at modeling individual proteins, but extending these capabilities to protein complexes remains a major challenge. MSA Pairformer, a parameter-efficient protein la...
cell.com
Today I'm posting a blog about another ridiculous antibody blunder. Dozens of papers in the senescence and ageing field have mistakenly used an antibody for E. coli β-galactosidase when trying to stain for the human protein with the same name. forbetterscience.com/2026/07/21/d...
🚨 new paper alert 🚨 Here we apply our protein nanoparticle vaccine platform toward a bacterial indication: uropathogenic E. coli, the primary causative agent of UTIs: bit.ly/4waDqaM
Frontiers | Improving the immunogenicity of E. coli FimH via multivalent display on I53-50 nanoparticles
Urinary tract infections, caused primarily by uropathogenic E. coli, are a significant public health burden, affecting approximately 50% of women worldwide. ...
bit.ly
Thrilled to share our collab led by Grace Hibshman with the Shipman lab! Type IX retron-Kva2 structure reveals phage detection via an HTH fold, not a primary sequence. We computationally designed triggers that program bacteria cell death, pointing toward designer antimicrobials.
We have a PhD position at Sanquin Research in Amsterdam involving protein engineering, de novo design and antibody development related to bleeding disorders. Please share this with anybody to whom this may be relevant! 🩸 🧬 🧪 🧫 www.sanquin.nl/en/working-a... www.linkedin.com/jobs/view/44...
Sanquin hiring PhD Candidate: Antibody Therapy for Bleeding Disorders in Amsterdam, North Holland, Netherlands | LinkedIn
Posted 10:24:43 AM. The Division of Research and Lab Services of Sanquin is home to 250 researchers, including over 60…See this and similar jobs on LinkedIn.
linkedin.com
Alles op alles zetten om je eigen misdadige handelen af te dekken. Maar de staatssecretaris heeft geen aanwijzingen dat het met opzet gebeurd is. www.trouw.nl/politiek/rap...
35th Glycobiology Meeting October 2026 - in Leiden, Netherlands 🇳🇱 jgm2026.aanmelder.nl/registration
https://jgm2026.aanmelder.nl/registration
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jgm2026.aanmelder.nl
CasanovoGUI: a cross-platform desktop application for deep learning-based de novo peptide sequencing with Casanovo https://www.biorxiv.org/content/10.64898/2026.07.11.737889v1
research.pasteur.fr/en/call/mid-...
Mid-career Group Leader position in Chemistry for Health at Institut Pasteur, Paris - Research
Institut Pasteur and the CNRS are launching a joint call for a mid-career group leader position in Medicinal Chemistry and Chemistry for Health. We are looking for an experienced researcher (typically...
research.pasteur.fr
De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging | Science www.science.org/doi/10.1126/...
De novo design of orthogonal far-red, orange, and green fluorophore-binding proteins for multiplexed imaging
Fluorescent proteins and small-molecule dyes offer complementary advantages for biological imaging: proteins are amenable to genetic tagging, whereas dyes provide superior brightness and photostabilit...
science.org
