Joseph Hughes

@bljog.bsky.social

https://bioinformatics.cvr.ac.uk/people/joseph-hughes/ Bioinformatics, phylogenetics, open science, bikes and cycling, ranting. Views my own.

Converting images to trees has a long history. @arambaut.bsky.social wrote TreeThief many years ago, @bljog.bsky.social released TreeRipper over a decade ago doi.org/10.1186/1471..., the list goes on. All because people don't share machine readable phylogenies 😞

TreeRipper web application: towards a fully automated optical tree recognition software - BMC Bioinformatics

Background Relationships between species, genes and genomes have been printed as trees for over a century. Whilst this may have been the best format for exchanging and sharing phylogenetic hypotheses during the 20th century, the worldwide web now provides faster and automated ways of transferring and sharing phylogenetic knowledge. However, novel software is needed to defrost these published phylogenies for the 21st century. Results TreeRipper is a simple website for the fully-automated recognition of multifurcating phylogenetic trees ( http://linnaeus.zoology.gla.ac.uk/~jhughes/treeripper/ ). The program accepts a range of input image formats (PNG, JPG/JPEG or GIF). The underlying command line c++ program follows a number of cleaning steps to detect lines, remove node labels, patch-up broken lines and corners and detect line edges. The edge contour is then determined to detect the branch length, tip label positions and the topology of the tree. Optical Character Recognition (OCR) is used to convert the tip labels into text with the freely available tesseract-ocr software. 32% of images meeting the prerequisites for TreeRipper were successfully recognised, the largest tree had 115 leaves. Conclusions Despite the diversity of ways phylogenies have been illustrated making the design of a fully automated tree recognition software difficult, TreeRipper is a step towards automating the digitization of past phylogenies. We also provide a dataset of 100 tree images and associated tree files for training and/or benchmarking future software. TreeRipper is an open source project licensed under the GNU General Public Licence v3.

doi.org

Fully funded PhD in virology - CVR & The Pirbright Institute Vector-imposed constraints on the evolution and diversity of bluetongue virus. J. Hughes, P. Johnson, M. Guimera Busquets, C. Sanders, N. Forrester-Soto Deadline for application: 08/05/2026 - tinyurl.com/BTVevolution

FULLY FUNDED PhD - Vector-imposed constraints on the evolution and diversity of bluetongue virus at University of Glasgow on FindAPhD.com

PhD Project - FULLY FUNDED PhD - Vector-imposed constraints on the evolution and diversity of bluetongue virus at University of Glasgow, listed on FindAPhD.com

tinyurl.com

I think more studies need to be done in humans as it seems likely that antipyretics do more harm than good in some situations. Lowering body temperature could be neutralising a powerful antiviral defence. Thanks for reading this thread.

How does fever work? Our new Science paper shows how elevated body temperature can protect against severe influenza and that avian-origin viruses escape this defence. This is likely one reason why bird flus and some pandemic influenzas can be so severe.🧵 www.science.org/doi/10.1126/...

Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals

Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

science.org

“Many Swedish cities, including Stockholm, prioritize snow clearance very differently. They now clear walkways & bike paths first, especially those near bus stops & primary schools. Next, they clear local roads, & then, finally, highways.” Via @usa.streetsblog.org usa.streetsblog.org/2018/01/24/w...

Why Sweden Clears Snow-Covered Walkways Before Roads — Streetsblog USA

It's part of "gender-balanced" policy that reflects the fact that women walk more than men.

usa.streetsblog.org