Cogent & well-articulated explanation of the hidden pre-programmed biases of homeostatic microglia (sex-, age-, region-, experience- & exposure- dependent) that are only apparent when triggered to their next reactive state. Say goodbye to M1-M2 paradigm in CNS #glia #neuroinflammation #neuroskyence

Nature Reviews Neuroscience@natrevneuro.nature.com · last wk.

Microglial states revisited: from homeostasis to disease — a Review by Bart J. L. Eggen & Susanne M. Kooistra #neuroscience #neuroskyence www.nature.com/articles/s41...

Insane new research. Scientists gave asthma patients free electric stoves to replace their gas stoves, then checked to see if symptoms improved. Not only did symptoms improve, ditching gas was *better than medicine.* Details in today's newsletter: www.climatecoloredgoggles.com/p/electric-s...

Researchers used electric stoves to treat asthma. It worked.

The latest evidence that gas is bad for your health.

climatecoloredgoggles.com

San Diego Comic-Con will stay in San Diego through 2030, as just announced by Mayor Todd Gloria at the San Diego Convention Center.

San Diego Comic-Con To Stay In San Diego Until 2030

Whew, that's a long con!

comicbookclublive.com

Wow we humans (& our brains) aren’t as unique as we thought. Very well written, easy to understand and highly impactful study revealing varicose projection astrocytes are conserved actors in neuropathology across species #neuroskyence #neuroinflammation #glia www.science.org/doi/10.1126/...

Varicose projection astrocytes: Conserved reactive cells in brain pathology

Varicose projection astrocytes emerge as a conserved reactive phenotype linked to inflammation and brain pathology.

science.org

Centro de Neurociencias Cajal@cncajal-csic.bsky.social · 2w ago

What if a brain cell once considered a hallmark of healthy tissue was actually linked to disease? Our latest study, by @ulloaseverinolab.bsky.social, identifies varicose projection astrocytes as a neuroinflammatory phenotype across mammals. More info: shorturl.at/4Oti1

#neuroskyence #immunosky a rather unexpected role for IgM antibodies in modulating neuronal activity, but makes sense for a C1q mediated process. Cool stuff!

Soyon Hong@soyonhonglab.bsky.social · 4w ago

Thrilled to share: we show that neuronal hyperactivity drives C1q-mediated synapse loss via brain-recruited B cell/IgM, revealing unexpected neuroimmune crosstalk in the adult brain. Congrats to Gerard Crowley who led this w/ resilience & creativity & our whole team! www.science.org/doi/10.1126/...

It has been criminally underreported but Kelsey Pfendler has just rowed solo across the Pacific Ocean from the US coast to Hawaii in record time. A 2,400-mile unsupported journey in 43 days, 17 hours, and 55 minutes. Notably beating the Men’s record by 9 whole days.

Go team #microglia Just like mom….sometimes you really need a properly reactive microglia to make it all well again! #neuroskyence

Shicheng Guo@shihcheng.bsky.social · 2mo ago

Study finds enhancing microglial repair helps stroke recovery. Microglia persist post-stroke, but lose efficiency. Understanding can improve outcomes. 🧠📈 PMID:42129556, Nature 2026, @Nature https://doi.org/10.1038/s41586-026-10480-0 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

The results of a study in Nature Metabolism establish hyperglycosylation as a pathological driver of Alzheimer’s disease and highlight glycan metabolism as an actionable target in the fight against the disease. #alzsky #Neuroskyence 🧪

Hyperglycosylation is a metabolic driver of Alzheimer’s disease - Nature Metabolism

Through spatial multiomics, spatial stable isotope tracing and retrospective cohort analyses, this study identifies hyperglycosylation as a driver of Alzheimer’s disease and a promising therapeutic target.

go.nature.com

#academicsky #medsky #neuroskyence #immunosky read the thread quoted here - very concerning use of AI and automated review process in Frontiers series journals.

Michael Okun@michael-okun.bsky.social · 2mo ago

Over the last month I saw that human editors are now stripped of control. I could no longer stop the system from auto-inviting "reviewers" with zero relevant expertise. Even worse - the AI began actively revoking the invitations I manually sent out to actual, qualified experts.

Thanks to Annika and others in this thread who are pulling together resources on the OMB proposed rules changes. Now that my grant is submitted (😳) I am drafting a comment. Hope you will too!

Annika Barber@annikabarber.bsky.social · 2mo ago

Megathread about responding to new OMB grant funding rules (feel free to add/link more!) I was collecting these for me, but figured I'd round 'em up for everyone 🧪 What's the problem? arstechnica.com/science/2026... elizabethginexi.substack.com/p/summary-of...

Megathread about responding to new OMB grant funding rules (feel free to add/link more!) I was collecting these for me, but figured I'd round 'em up for everyone 🧪 What's the problem? arstechnica.com/science/2026... elizabethginexi.substack.com/p/summary-of...

Proposed new US funding rules: We can cancel any grant at any time

Peer review now optional, political staff would screen grants for forbidden topics.

arstechnica.com

The proposed rule raises significant concerns about the introduction of broad political and ideological considerations into federal funding decisions. Read SfN’s full statement on proposed OMB rule: vist.ly/56rqw #neurosky #scisky #medsky #neuroskyence

Copying what the Utah state legislature did with the leadership of the University of Utah to remove power from the Senate.

Kathleen Bachynski@bachynski.bsky.social · 2mo ago

“The Auburn University Board of Trustees on Friday gave itself complete control over course offerings, curriculum, degree requirements and academic credentials while eliminating shared governance at the Alabama land-grant university… The policy leaves many questions unanswered”

Wow! #microglia really do know what’s going on. Like any self-respecting tissue #macrophage , they have a tissue specific sensing and they specialize to support the functions of their tissue. Here, see this applied to respond to a brain implant. Fun stuff #neuroskyence

TK (Takashi DY) Kozai@bioniclab.bsky.social · 2mo ago

🕵️ Your brain's immune system isn't fighting the implant. It's listening to it. The textbook story: immune system sees foreign object, attacks, builds scar. Incomplete. We found microglia monitor what the device does to nearby neurons in real time, then adjust behavior to match. 🧵

Jennell Jennett, Class of 2026, happened to start a job in biotechnology after studying microbiology in college—and found her true calling. Her love of research led her to a PhD in biomedical sciences at UCR.

A Love of Science: Jennell Jennett, Class of 2026

After studying microbiology in college in Arizona, Jennell Jennett considered becoming a doctor. Yet while working in a primary care office after earning her bachelor’s degree, she soon understood tha...

somnews.ucr.edu

Again, please share. In every aspect of American history you will run smack dab into the critical contributions of Black people. It’s not Black history. It’s American history. Trying to erase it is a fool’s errand. We live it every day. time.com/5836444/blac...

The Forgotten Black History of How Memorial Day Started

Historians like the Pulitzer Prize winner David Blight have tried to raise awareness of freed slaves who decorated soldiers' graves in 1865

time.com

Stephen Colbert is a national treasure: The day after his show was canned after 11 years by CBS to appease a tyrant, he shows up on the Monroe, MI public access channel where he did his first Late Show broadcast in 2015.

Only In Monroe --- May 22, 2026

YouTube video by Stephen Colbert

youtu.be

‘Dawn Staley’ would’ve been so easy to spell.

Put some more respect on her name. Coach Dawn Staley!!!! Congratulations to the GOAT!!!

Here here for retiring an often overgeneralized M1-M2 binary phenotypic framework. #macrophages express an incredible large array of sensome receptors that allow them to tailor their phenotype and reactions to the needs of incredibly local environments. #neuroskyence #immunosky #glia

Danny Saban@sabanlab.bsky.social · 4mo ago

Bonus 1/3 (for Blusky only!) We argue for sunsetting the M1/M2 dichotomy in eye macrophage research, supported by single cell RNA-seq data demonstrating a complexity that does not conform to this binary framework

Awesome discussion for those of us who love resident #macrophages in all their forms, and wonder what allows some to be be self renewing #neuroskyence #immunosky #glia #neuroinflammation

Danny Saban@sabanlab.bsky.social · 4mo ago

Resident tissue #macrophages (RTM) are now recognized as integral regulators of tissue physiology, not transient immune sentinels. one fundamental question remains unresolved: why do some populations achieve lifelong self-maintenance, while others are replaced under steady-state conditions? 🧵1/11

It’s Pi Day! The perfect time to listen to the perfect song about Pi, by the wonderful @lucykaplansky.bsky.social www.youtube.com/watch?v=nJkw...

Lucy Kaplansky - "A Song About Pi" (Official Video)

YouTube video by Lucy Kaplansky

youtube.com

The Senate has (finally) voted to reauthorize the small business SBIR/STTR program. Not reauthorized yet, but this was likely the biggest hurdle.

Worth a read: de-siloing research is critical for understanding brain function, brain health and innovative treatment and repair paradigms- as noted here, to do so means it’s critical to utilize observed differences and concordance between species and studies #neuroskyence #glia

The Transmitter @thetransmitter.bsky.social · 6mo ago

If neuroscience is serious about building general principles of brain function, cross-species dialogue must become a core organizing principle rather than an afterthought, writes @suthanalab.bsky.social. #neuroskyence www.thetransmitter.org/animal-model...

📰 ISN News Issue 5 is out! Explore the latest updates, insights, and stories from across the neurochemistry community. 🖼️ Cover image: Silvia Mangia 🔗 Read it here: bit.ly/3OsjMWL #WeAreNeurochemistry #ISNNews #Neuroskyence #Neurosky

🚨Do we need a large, expensive MRI scanner to map whole-brain networks in the mouse? Not necessarily! In our new preprint ▶️ tinyurl.com/3a2h4r9f we show that transcranial functional ultrasound (fUSI) can map connectome-scale networks with striking agreement to fMRI 🧵👇

Celebrities and talent who do shows for Apple TV should publicly ask the company when SAVANT will be released and why they pulled a show about white supremacists and domestic terrorism? (We know why but pressure them.) www.rollingstone.com/tv-movies/tv...

Whatever Happened to Jessica Chastain's Show on Domestic Terrorism?

Five months after 'The Savant,' Jessica Chastain’s show on domestic terrorism, was set for release, its fate is still uncertain, and no one is talking

rollingstone.com

#measles is dangerous. ~30% of cases result in serious complications, particularly in children <5 & adults >30. Bonus: Measles causes "immune amnesia", wiping out ~70% of immune memory cells, eliminating body’s immune toolkit gained in past infections, increasing vulnerability to all infections

Fiona "Fi" Webster 🌎🌍🌏@fiona-webster22.bsky.social · 6mo ago

The measles virus infects ~90% of unvaccinated people exposed to it. The infected can then infect a dozen to several hundred people each. This well-researched piece is a chilling, powerful account of exactly how easily a kid could get measles, and how they could die of it. Must read! Gift link.

“The Obamas are competent, classy, loving, Harvard and Princeton graduates, loved by many, not in the Epstein files, got the Nobel Peace Prize, and gave us a steady economy to boot…”