Brett L. Foster

@brettlfoster.bsky.social

Associate Professor of Neurosurgery @upenn.edu | Neuroscientist | Human Neurophysiology, Neuromodulation & Neurotechnology | Memory & Perception | 🇦🇺 | https://www.fosterneurolab.com/

(New results!) Human inference behavior varies widely across individuals and tasks. Using the information bottleneck framework, we show that two distinct axes capture a substantial amount of individual variability across two classic inference tasks. Thread below 1/

An information-bottleneck theory of suboptimal human inference

Human inference is often suboptimal in ways that vary across individuals and tasks. We propose that this variability reflects information processing limits and develop a task-general application of th...

biorxiv.org

New preprint! We show low arousal states promote hippocampal ripple genesis in sleep and wake. This bridges rodent work, where ripples predominate during sleep, with human studies reporting ripples during active behavior, identifying low arousal as a common mechanism www.biorxiv.org/content/10.6...

Arousal state modulates human hippocampal ripples

Hippocampal ripples are transient, high-frequency oscillations linked to memory replay and consolidation. Ripples are well-characterized in rodents to occur during periods of behavioral inactivity (i....

biorxiv.org

🔔 Preprint: “Hippocampal ripples evoke a stereotyped cortical response followed by spindle-mediated network synchronization.” Combining iEEG+scalp EEG during sleep, we show that hippocampal ripples leave a decodable cortical fingerprint and are followed by brain-wide spindle synchronization!

doi.org

We’ve got an exciting new thing to share! We have causal evidence (using TMR) that memory reactivation during sleep promotes abstract understanding of underlying structure, allowing transfer learning in a new domain with zero superficial feature overlap with the learned one.

Sarah Solomon@sarahsolomon.bsky.social · 4mo ago

Super excited to share this preprint! How do we disentangle underlying structure from the particular features of a learning episode to benefit future learning? We find that memory reactivation during sleep promotes this structure abstraction process. www.biorxiv.org/content/10.6...

Our new paper in @sfnjournals.bsky.social shows different neural systems for integrating views into places--PPA integrates views *of* a location (e.g., views of a landmark), while RSC integrates views *from* a location (e.g., views of a panorama). Work by the bluesky-less Linfeng Tony Han.

SfN Journals@sfnjournals.bsky.social · 7mo ago

#JNeurosci: Using fMRI, Han and Epstein explored how people integrate different kinds of views to form mental maps of places, revealing two sets of brain regions involved in integrating views of landmarks into existing mental maps of a virtual city. https://doi.org/10.1523/JNEUROSCI.0187-25.2025