In collaboration with @mattevilab.bsky.social, we share in @naturecomms.bsky.social our work studying the mechanism of LSD1 covalent ‘formylators’. Many LSD1 inhibitors create a bulky FAD-drug adduct. Discovered by Takeda by phenotypic screening, these formylators serendipitously create formyl-FAD.
I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and
Oxidation of retromer complex controls mitochondrial translation - Nature
Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...
nature.com
Interested in small molecule mechanism? If you’re at #ACSSpring2025, stop by the Eli Lilly Symposium Wed 9am–12pm @ Room 31A in the convention center. Cool talks from @michael-erb.bsky.social, Yuh Min Chook & @xiaoyuzhang.bsky.social. I’ll discuss our program on chemical genomics. Come check it out!
Delighted to share this work led by @mekedlawitts.bsky.social that investigates the delivery efficiency of various protein delivery vehicles! pubs.acs.org/doi/10.1021/...
Engineering Cell-Specific Protein Delivery Vehicles for Erythroid Lineage Cells
Biologics such as proteins, peptides, and oligonucleotides are powerful ligands to modulate challenging drug targets that lack readily accessible and “ligandable” pockets. However, the limited membran...
pubs.acs.org
Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...
Molecular glue unexpectedly mimics the effect of cancer mutations
Protein structures could guide the design of molecular glue degraders.
nature.com
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
