Thomas Yeo

@bttyeo.bsky.social

Brain imaging, machine learning, neuroscience, mental disorders https://sites.google.com/view/yeolab

A video of a patient who responded well to personalized TMS: www.temasekreview.com.sg/community-st...

temasekreview.com.sg

Thomas Yeo@bttyeo.bsky.social · 2mo ago

Our TMS algorithm is now published in @imagingneurosci.bsky.social doi.org/10.1162/IMAG... If you are coming to @ohbmofficial.bsky.social @ohbmtrainees.bsky.social, come check out our poster about our open label trial. Poster number 1152 Monday, Jun 15 | 14:45-15:45 Tuesday, Jun 16 | 13:30-14:30

Excited that Imaging Neuroscience has gotten its impact factor. Note that the impact factor is artificially low for the first year of any journal (because of the way it is calculated), so we expect the impact factor to improve next year. See more statistics below

Imaging Neuroscience@imagingneurosci.bsky.social · 2mo ago

A note on first IF for new journals: IF is based on citations in year 3 of papers published in years 1 and 2. As papers from year 1 have longer to accrue citations, the smaller launch-year output reduces the first combined calculation. This effect disappears the following year.

Our first Impact Factor is 3.0 — an important milestone for a new journal. As with most new journals, the first IF is affected by the smaller publication volume in the launch year. Latest citation data are encouraging, and the journal’s IF is set to rise in 2027.

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For those at @ohbmofficial.bsky.social @ohbmtrainees.bsky.social come check out our poster on using deep learning to accelerate biophysical model fitting & resulting insights into lifespan changes in E/I ratio! Poster number 2304 Wed, June 17 | 13:45-14:45 Thurs, June 18 | 14:45-15:45

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Thomas Yeo@bttyeo.bsky.social · 4mo ago

Updated preprint: doi.org/10.1101/2025... We have improved DELSSOME and showed that we can accelerate the estimation of two new biophysical models. By collating 12,005 individuals, we derive normative trajectories of cortical E/I ratio across the lifespan ...

One interpretation: baseline salience FC reflects the attractor basin characteristics of that network or how reliably it settles into coherent functional states. Low FC = shallow, poorly defined basins. The network can get there, but with more variability and less precision.

Openly shared implementation of TMS targeting is still rare, so we are pleased to make ours freely available for research use: github.com/ThomasYeoLab... Let us know if you have any issue running it!

GitHub - ThomasYeoLab/Kong2026_TMSTree: Tree-based MS-HBM TMS targeting algorithm

Tree-based MS-HBM TMS targeting algorithm. Contribute to ThomasYeoLab/Kong2026_TMSTree development by creating an account on GitHub.

github.com

Thomas Yeo@bttyeo.bsky.social · 2mo ago

Our TMS algorithm is now published in @imagingneurosci.bsky.social doi.org/10.1162/IMAG... If you are coming to @ohbmofficial.bsky.social @ohbmtrainees.bsky.social, come check out our poster about our open label trial. Poster number 1152 Monday, Jun 15 | 14:45-15:45 Tuesday, Jun 16 | 13:30-14:30

If you are attending @ohbmofficial.bsky.social @ohbmofficial.bsky.social come by and check out our poster on how excessive censoring hurts parcellation and personalized TMS target accuracy. Poster number 2399 Presenting on Wednesday, June 17 (12:45-13:45) and Thursday, June 18 (13:45-14:45)

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Thomas Yeo@bttyeo.bsky.social · 4mo ago

Do you censor high motion frames in fMRI? In two preprints by @twktan.bsky.social @mandymejia.bsky.social, we find that we may be censoring too much! doi.org/10.64898/202... arxiv.org/html/2603.07... Strict censoring leads to worse personalized TMS targets than no censoring, even with high motion!

Here's bonus slides on cross-validation tests, separate from our preprint. Covering: 1. paired (sign-flip) permutation test 2. label-swap permutation test 3. sample-level vs fold-averaged stats 4. a common misapplication of the corrected t-test 5. three bootstrap variants 1/N

Thomas Yeo@bttyeo.bsky.social · 3mo ago

In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N

For years, we've known that running a standard t-test on cross-validation folds violates sample independence. We wanted to see how widespread this issue actually is. The result? 97% of the studies used an invalid statistical test. 🧵👇

Thomas Yeo@bttyeo.bsky.social · 3mo ago

In a meta-analysis of 210 biomedical AI studies that statistically compared models under cross-validation, 97% used invalid statistical tests. Here's our new preprint doi.org/10.64898/202... led by @tianchu.bsky.social @hetuli.bsky.social @shaoshiz.bsky.social @nichols.bsky.social 1/N

Can't stress this enough 👇 If you use ML to compare predictive models in your research (neuroscience, genetics, you name it), this paper is a must read! 👀 The majority of work in this space (mine included 🙋) misses critical nuances when reporting comparative stats.