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Buttitta Lab

@buttittalab.bsky.social

Studying cell cycle regulation during development at the University of Michigan. also at buttitta@drosophila.social

21 Posts496 Follower945 Folgt
Buttitta Lab@buttittalab.bsky.social · 2w ago

Wow. Can’t wait to share this story with my next undergrad Cancer Bio class. (We also cover the other 3 examples).

Vincent J Lynch 🐘🦣🦥 🦇🐋🐢🐍@devoevomed.bsky.social · 2w ago

Can't stop thinking about this; transmissible cancers are so crazy, extremely rare (tassie devils, dogs, some clams), but I wonder why? It seems like it should be very common. It's advantageous for the cancer to escape the dead-end host. And yet... www.nature.com/articles/s41...

Buttitta Lab@buttittalab.bsky.social · 3mo ago

I was truly impressed with the breadth of topics, quality and numbers of undergrad research posters yesterday at the UM UROP and UM Program in Biology&Neuroscience poster sessions. A great reminder of the impact of hands-on research experience in education! @umich.edu

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Buttitta Lab@buttittalab.bsky.social · 5mo ago

Reminder of a fantastic meeting coming up in July - FASEB Cell Cycle Regulation in Health and Disease. Note this meeting is also co-located with the FASEB Yeast Chromosome Biology Yeast Conference w/ shared poster session and joint talks. Please share! events.faseb.org/event/cell-c...

Cell Cycle Regulation in Health and Disease.

Explore breakthroughs in cell cycle regulation and its impact on disease and therapies at this new multidisciplinary scientific meeting.

events.faseb.org

Dr. Matt Schabath (he/him/his)@mattschabathphd.bsky.social · 9mo ago

🧪🧪 Nobel laureate Hamilton Smith, who discovered molecular 'scissors' to cut DNA, dies at 94 -- Smith, a microbiologist whose discovery revolutionized the field of genetic engineering, was a Johns Hopkins School of Medicine alumnus and professor emeritus hub.jhu.edu/2025/11/04/n...

Nobel laureate Hamilton Smith, who discovered molecular 'scissors' to cut DNA, dies at 94

Smith, a microbiologist whose discovery revolutionize the field of genetic engineering, was a Johns Hopkins School of Medicine alumnus and professor emeritus

hub.jhu.edu

Alejandro Montenegro@aemonten.bsky.social · 10mo ago

PREACH! www.nature.com/articles/s41...

Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology

As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

nature.com

Emilio M Bruna@brunalab.bsky.social · last yr.

Proposed cut to NSF Biology budget is 70%. 70%. Seventy. Call your senators & reps nonstop. Give them numbers on NSF impact for state/district. tableau.external.nsf.gov/views/NSFbyN... explain this will decimate the economy if their districts, especially if it has a major research univ. 🧪

Tableau

tableau.external.nsf.gov

Dan Garisto@dangaristo.bsky.social · last yr.

Presidential budget is out. Here's NSF. Biggest cut, by amount, is $1 billion, or 66.8%, from MPS (Physics & Math directorate). nsf-gov-resources.nsf.gov/files/00-NSF...

MPS budget
Buttitta Lab@buttittalab.bsky.social · last yr.

Pleased to share and amplify our most recent paper. Looking at #oncogene effects in the #drosophila #prostate which is #postmitotic and #polyploid. 🧪

DMM Journal@dmmjournal.bsky.social · last yr.

The fruitfly prostate-like accessory gland is a postmitotic and polyploid tissue. S. Jaimian Church, @buttittalab.bsky.social & co show similarities between the oncogenic activity in the Drosophila accessory gland and in polyploid prostate cancer. doi.org/10.1242/dmm.... #prostatecancer #cancer

Oncogenic activation leads to endocycling and tissue hypertrophy in the adult Drosophila accessory gland. (A) Diagram showing the major features of the Drosophila accessory gland. (B) DIC images of accessory glands with ejaculatory ducts exhibiting basal protrusions when YkiWT+P35 is expressed in adults. (C) Optical cross-sections of glands expressing the indicated transgenes for 10 days. (D) Optical coronal section through glands and ejaculatory duct expressing Myc+E2f/Dp+P35 exhibiting apical hypertrophy invading the lumen and a basal protrusion. (E) Split bar plot showing the frequency of accessory glands with apical or basal protrusions at various time points. d, day. (F) EdU labeling of flies from 6 to 10 days with transgene induction 24-48 h post eclosion. (G) DAPI integrated density measurements (DAPI intensity) after 10 days of transgene expression. (H) Flow cytometry measurements of ploidy from isolated nuclei at 10 days.
Ardem Patapoutian@ardemp.bskyverified.social · last yr.

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.” A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world. www.cnn.com/2025/04/09/h...

Nobel laureate: I owe America my success. Today, its scientific future is in danger | CNN

Dr. Ardem Patapoutian says he watches “with deep sadness as the United States’ remarkable scientific enterprise, which took generations of hard work and national investment to build, faces a concerted...

cnn.com