In a new preprint led by Ves Manojlovic, we develop an agent-based model and an ABC-SMC inference workflow to infer tumour growth parameters from methylation arrays, focussing on sites whose states fluctuate on clinically relevant timescales. We applied this workflow to 10 colorectal tumours. 1/2

Fluctuating DNA methylation sites encode colorectal tumour growth history

Determining the nature of human tumour growth is challenging given the impracticality of obtaining detailed data across time. A promising solution is to examine DNA regions whose methylation states fl...

biorxiv.org

How do cells lining our epithelium evolve over a lifetime? 🧬 We built PHYFUM, a new Bayesian phylogenetic method to reconstruct the evolutionary history of normal tissue using Fluctuating Methylation. Here's what we found 👇 #CancerEvolution doi.org/10.64898/202...

Trevor Graham@trevorgraham.bsky.social · 3mo ago

In colon, stem cells divide & so do the crypts they reside in: a multi-level evolutionary process. D Mallo, P Bousquets @heathergrant.bsky.social @calumgabbutt.bsky.social have made "PhyPhum" to lineage trace somatic evolution in human glandular tissues www.biorxiv.org/content/10.6... @icr.ac.uk

In colon, stem cells divide & so do the crypts they reside in: a multi-level evolutionary process. D Mallo, P Bousquets @heathergrant.bsky.social @calumgabbutt.bsky.social have made "PhyPhum" to lineage trace somatic evolution in human glandular tissues www.biorxiv.org/content/10.6... @icr.ac.uk

If you're interested in integrating theory and data to better understand how cancers evolve, register for the 2nd CANPOP meeting! Featuring a keynote talk from Martin Taylor (@mstaylor.bsky.social) and selected short talks, what better way to spend an afternoon? forms.gle/jSxB1TdPURRa...

If you’re interested in machine learning and mathematical modelling, we’re recruiting a PhD student to develop new methods for studying cancer evolution at @imperialimmuno.bsky.social www.findaphd.com/phds/project...

Developing machine learning methods to infer the evolution of haematological cancers at Imperial College London on FindAPhD.com

PhD Project - Developing machine learning methods to infer the evolution of haematological cancers at Imperial College London, listed on FindAPhD.com

findaphd.com

An incredible opportunity for early career researchers - Imperial's Faculty of Medicine is hiring 20 Assistant Professors!

Department of Immunology and Inflammation@imperialimmuno.bsky.social · 6mo ago

We're #hiring for new non‑clinical Assistant Professors! Keen to join us at the Department of Immunology and Inflammation? Make sure to select ‘Immunology and Inflammation’ as your first preference when applying. ✍️Apply by 11 March 2026. 👉 www.imperial.ac.uk/jobs/search-...

We held the first #CANPOP symposium today (cancer population genetics club) @icr.ac.uk. 6 excellent & didactic talks, all applying mathematical #popgen theory to dissect somatic evolutionary dynamics: spanning the full range of pre-cancer, metastasis through to 6000 year old transmissible cancer...

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

nature.com

Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7) rdcu.be/eFrrc

Fluctuating DNA methylation tracks cancer evolution at clinical scale

Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

rdcu.be

🚀 AI in Science Fellowships – Applications Now Open! The I-X Centre for AI in Science is recruiting up to 19 fellows to join their prestigious programme and accelerate artificial intelligence research in Engineering, Natural and Mathematical Sciences. 1/5

Imperial's Schmidt AI in Science fellowships are now open! As a current fellow, I can highly recommend applying for these prestigious and enriching awards. No prior AI experience needed, just a scientific problem suited to AI. For cancer researchers there are dedicated joint positions with the ICR.

Schmidt Fellowships for #AI in #cancer research 2025 round is now open. These are pathway to independence fellowships between @icr.ac.uk & @imperialcollegeldn.bsky.social that support fellows to be competitive for faculty jobs at the end of the 2 year funding. www.imperial.ac.uk/jobs/search-...

New preprint! Let me tell you a story about trees, caterpillars, brooms, entropy, and getting scooped by 50 years. Rooted trees of all shapes and sizes crop up all over biology, computing and elsewhere. How can we best compare the shapes of these myriad trees? 1/14 arxiv.org/abs/2507.08615

Interested in population genetics of cancer? If so, have a look at our manuscript accepted by @genetics-gsa.bsky.social, in which we provide a theoretical assessment of the genetic makeup of cancers before and after treatment!

Benjamin Werner@benjaminwerner.bsky.social · last yr.

Very happy that @alexsteinresearch.bsky.social manuscript on the patterns of genetic heterogeneity before and after treatment is out now: academic.oup.com/genetics/adv... We build on and expand the population genetics theory of gITH. Very worth a read if you are interested in somatic evolution.

Calling data scientists: we have opening in our Data Science core @icr.ac.uk to lead work around cancer spatial biology and single cell analysis. These are staff scientist type positions, ideal for someone who wants to help drive computational research. Apply here: jobs.icr.ac.uk/vacancies/12...

Data Scientist in Sutton | The Institute of Cancer Research

View details and apply for this Data Scientist vacancy in Sutton. Salary : Salary range £39,805 to £49,023 (depending on the experience) Reporting to: Professor Trevor Graham ...

jobs.icr.ac.uk

If you're a PhD student interested in using maths to understand cancer, this HCEMM summer school in Szeged, Hungary, is an excellent opportunity. Registration is free and local costs are covered, so apply before 15th April.

This week-long summer school looks set to be an excellent opportunity for to learn about cancer evolution! Bursaries are available for those who require financial assistance, deadline 1st April.

Wellcome Connecting Science Learning and Training@eventswcs.bsky.social · last yr.

Working in #CancerBiology? Join us at our expert-led #EBECancer25 course, to discover how insights on the #evolutionary and ecological aspects of #cancer are shaping the future for improved clinical treatments.💊 📅 30 June-3 July 2025 ⏰Apply by 1 April! 📎bit.ly/40nLdDD @sysbiocurie.bsky.social

Does the evolutionary history of a cancer predict patient outcome? In our new pre-print, we introduce a powerful new method to measure a cancer’s past using bulk methylation data. In chronic lymphocytic leukaemia (CLL), these inferred histories are highly prognostic! (1/9) doi.org/10.1101/2023...