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Camila dos Santos

@caoresco.bsky.social

Associate Professor at CSHL - mom of 2 humans and 2 dogs - interested on women’s health and epigenetic regulation of breast development and cancer. Running enthusiastic. Music lover.

12 Posts238 Follower172 Folgt
Camila dos Santos@caoresco.bsky.social · 3mo ago

My team is moving the amazing St. Jude Children’s Reseerch Hospital in August and we have 2 postdoctoral positions available to study the intersection between genetics, women’s health, and breast cancer risk. Check it out! talent.stjude.org/careers/JobD...

Postdoctoral Research Associate - Oncology

Our previous work has uncovered key mechanisms linking systemic changes to tumor initiation, single cell signatures of models of breast normal and cancer development and identified epigenetic and...

talent.stjude.org

Camila dos Santos@caoresco.bsky.social · 10mo ago

Are you looking for a reliable strategy to quantify the architecture of mammary tissue using whole mount images?? Well, maybe you should check MaGNet, our new computational based and user friendly approach (and you probably can adapt it to other organs as well). link.springer.com/article/10.1...

MaGNet: A Network-Based Method for Quantitative Analysis of the Mammary Ductal Tree in Developing Female Mice - Journal of Mammary Gland Biology and Neoplasia

The mammary gland is a uniquely dynamic organ with a branching architecture that develops entirely after birth in response to hormonal cues. A common approach in mammary gland biology is the evaluation of branching morphogenesis to characterize the role of developmental, physiological and molecular perturbations on branching tissue invasion, growth, and maintenance. Yet, the field still lacks a fully open-sourced, quantitative framework to analyze whole-mount mammary tissue images, as a commonly utilized methodology. Here, we present MaGNet (Mammary Gland Network analysis tool), a method that leverages network theory to characterize key features of ductal branching during mammary gland development. Applying this pipeline to mammary gland images captured at three pubertal timepoints, we achieved reproducible quantification of ductal tree expansion across development. In addition, this network analysis pipeline captures ductal expansion induced by pregnancy hormones. By providing open-source tools to the research community, this method may increase reproducibility and broad applicability across diverse organ systems, model organisms, and developmental stages.

link.springer.com

Hannah Meyer@hannahvmeyer.bsky.social · last yr.

Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!

T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database

Banerjee et al. present a comprehensive T cell receptor cross-reactivity database and a hierarchical Bayesian framework to predict T cell receptor targets. Together, they reveal structural and biochem...

cell.com

Peter Koo@pkoo562.bsky.social · 2y ago

I'm hiring: 1. Research associate (wet-lab w/ phd) to generate mpra perturbation data 2. ML postdoc to build multimodal generative AI for DNA (eg diffusion and LLMs) 3. Bioinformatician (any level) to process and harmonize functional genomics data to train foundation models DM me if interested!

Thiago Carvalho@cyrilpedia.bsky.social · 2y ago

'The polio virus is still circulating worldwide. In 2022, an unvaccinated man in Rockland County, N.Y., was paralyzed by polio. Earlier this year, the virus paralyzed a child in Gaza, the first case in the region in 25 years, which prompted a mass vaccination campaign against polio.'

What the Polio Vaccine Has Meant for Public Health

A lawyer working with Robert F. Kennedy Jr. has asked the F.D.A. to withdraw approval of the current shot because it hasn’t been tested against a placebo. Scientists say such a test would be unethical...

nytimes.com

Jeremy Borniger@jborniger.bsky.social · 2y ago

1st post on bluesky! I might as well use this opportunity to plug our recent preprint where we identify a potential neurophysiological mechanism driving aberrant HPA-axis activity in breast cancer. www.biorxiv.org/content/10.1...

A brain-body feedback loop driving HPA-axis dysfunction in breast cancer

Breast cancer patients often exhibit disrupted circadian rhythms in circulating glucocorticoids (GCs), such as cortisol. This disruption correlates with reduced quality of life and higher cancer morta...

biorxiv.org

Camila dos Santos@caoresco.bsky.social · 2y ago

Check out our News and views on @carman-mc-li.bsky.social cool study about the molecular regulation of Brca1 deficiency mammary oncogenesis - with Steven Lewis www.nature.com/articles/s41...

Epigenetic scars of Brca1 loss point toward breast cancer cell of origin - Nature Genetics

The two-hit hypothesis suggests that a second mutation is necessary for cancer development in cells with a defective tumor-suppressor gene, such as BRCA1. However, a study now shows that the loss of j...

nature.com

Harvard Med Cell Biology@harvardcellbio.bsky.social · 2y ago

New work from Joan Brugge's lab @harvardcellbio.bsky.social explores how Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer - Led by Carman Li www.nature.com/articles/s41...

Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer - Nature Genetics

A second hit to Brca1 in heterozygous mice leads to accelerated tumor development compared to wild-type mice in which both alleles are simultaneously deleted. This is because of an epigenetic state as...

nature.com