Supported by fantastic collaborators, we have developed computer simulations of cardiac growth that reproduce eccentric and concentric growth associated with sarcomeric protein variants, mitochondrial dysfunction, hypertension, and valve insufficiency. www.biorxiv.org/content/10.6...

Researchers at UK have been awarded a prestigious Centers of Biomedical Research Excellence (COBRE) grant. This five-year, $11 million grant will strengthen the foundation of diabetes prevention research throughout the Commonwealth. Learn more: https://bit.ly/3Xf9E52

Alpbach Motors Workshop, brilliant discussion-based motility meeting in a stunning alpine setting in Austria, March 21-27, 2026. Registration open until December 19. Best conference hotel ever. www.boeglerhof.at/en Register at: docs.google.com/forms/d/e/1F...

We will soon be looking for a comp biologist or bioinformatician to work on a number of linked projects within the lab - main focus is on molecular control of muscle Before the official advert is published, I’m hoping to spread the news to any talented near-finishing PhDs or keen postdocs!

Lovely profile of Mindy Thompson, one of our lab's great alumni. medicine.uky.edu/news/saying-...

Saying yes to opportunity: How Mindy Thompson built a career at UK

medicine.uky.edu

On behalf of our team at @ukresearch.bsky.social, highlighting "Patients who donate biospecimens for research leave a valuable and underappreciated scientific legacy". We can all remember that behind every data point is a person, a family, and a story. www.ahajournals.org/eprint/8HECU...

Congrats to new #NobelLaureates Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi for their discoveries of peripheral immune tolerance and T reg cells. Read more: https://ow.ly/aiHn50X74mS #NobelPrize #Physiology

A recent article in Circulation Research highlights findings from the van Berlo research lab, indicating that the cytoskeletal protein Septin4 plays a role in the onset of cardiac fibrosis by modifying the function of calcineurin. Read the full article: buff.ly/EUNsdKG #UMNresearch #Cardiosky

Delighted to see myocardial samples donated by patients and organ donors at @ukresearch.bsky.social supporting another important publication. Thank you for the opportunity to contribute. academic.oup.com/cardiovascre...

RRAD-reduction reveals efficacy of targeting L-type calcium channel regulation for treatment of heart failure

AbstractAims. Heart failure with reduced ejection fraction (HFrEF) is a major health problem. Increasing L-type calcium channel (LTCC) activity deteriorate

academic.oup.com

Our department is recruiting a new tenure track Assistant/Associate Professor. Come join the #1 physiology department in the country and some awesome colleagues doing high impact science and training the next generation of scientists jobs.sciencecareers.org/job/674815/a...

Assistant/Associate Professor - Tenure Track - Physiology - University of Michigan, Ann Arbor job with University of Michigan Department of Molecular & Integrative Physiology | 674815

Tenure track assistant/associate professor in the Department of Molecular & Integrative Physiology at the University of Michigan Medical School.

jobs.sciencecareers.org

Please repost! We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky

#musclesyneRgies 1.2.5.9009 (development version) How to install 𝚒𝚗𝚜𝚝𝚊𝚕𝚕.𝚙𝚊𝚌𝚔𝚊𝚐𝚎𝚜("𝚛𝚎𝚖𝚘𝚝𝚎𝚜") 𝚛𝚎𝚖𝚘𝚝𝚎𝚜::𝚒𝚗𝚜𝚝𝚊𝚕𝚕_𝚐𝚒𝚝𝚑𝚞𝚋("𝚊𝚕𝚎𝚜𝚊𝚗𝚝𝚞𝚣/𝚖𝚞𝚜𝚌𝚕𝚎𝚜𝚢𝚗𝚎𝚁𝚐𝚒𝚎𝚜") Improved function CoA with non-duplicated angles and robust quadrant handling. Please update! #rstats #opensource github.com/alesantuz/mu...

GelBox - reproducible analysis of gels and immunoblots campbell-muscle-lab.github.io/GelBox/ pubmed.ncbi.nlm.nih.gov/39092999/

Congrats to Brent Scott from the Greenberg lab for this new paper on danicamtiv's mechanism of action. www.pnas.org/doi/10.1073/... Excited to see our FiberSim code being put to such good use. campbell-muscle-lab.github.io/FiberSim/

Danicamtiv reduces myosin’s working stroke but activates the thin filament by accelerating actomyosin attachment | PNAS

Heart failure is a leading cause of death worldwide, and even with current treatments, the 5-y transplant-free survival rate is only ~50 to 70%. As...

pnas.org

Can you really repair an engine while it's running? 👩🏽‍🔧 The heart can. 💪🏼🫀 Our latest @faseborg.bsky.social paper shows how the protein 'CapZ' helps heart muscle to keep running during exercise. ⛹🏼‍♀️🏊‍♂️ #Exercise #Heart #Muscle #BasicScience #Cardiology faseb.onlinelibrary.wiley.com/doi/10.1096/...

Cardiac CapZ Regulation During Acute Exercise in Female Mice

CapZ regulates actin addition at the barbed ends of sarcomeric actin. At rest, phosphorylated CapZIP slows addition, and dephosphorylated CapZIP promotes a wobble state to allow actin cycling. During...

faseb.onlinelibrary.wiley.com

Always exciting to see new HF agents in development! I enjoyed reading this interesting study using porcine model of HF with some promising outcomes for MiR-132. Available now in @escardio.bsky.social journal EHJ-IMP: academic.oup.com/ehjimp/artic...

MiR-132 inhibition improves myocardial strain in a large animal model of chronic left ventricular adverse remodelling

AbstractAims. Cardiac miR-132 has been proposed as a target for heart failure (HF) therapy. CDR132L, a rationally designed synthetic oligonucleotide inhibi

academic.oup.com

Very happy to have been awarded a NIRG from the MRC. Stay tuned for some exciting (I think, but being biased) postdoc positions within our lab!

King's Faculty of Life Sciences & Medicine@kingslsm.bsky.social · last yr.

Congratulations to Dr Robert Seaborne @kingscollegelondon.bsky.social who has been awarded a New Investigator Grant from the Medical Research Council (MRC), which will support his work on understanding the role of skeletal muscle in motor neurone disease. Read more ➡️ www.kcl.ac.uk/news/dr-robe...

Another great paper from Dan Beard's group at @umich.edu addressing measurements of the SRX / IHM / OFF state in myosin. www.biorxiv.org/content/10.1...

Kinetic Modeling of mant-ATP Turnover to Interpret the Biochemically Defined Myosin Super-Relaxed State

The fluorescent ATP analog mant-ATP has become a valuable tool for quantifying occupancy of the myosin super-relaxed (SRX) state, a biochemically inactive conformation of myosin in striated muscle. In...

biorxiv.org

More great research at @ukresearch.bsky.social uknow.uky.edu/research/qa-...

Q&A with Caroline Geisler: Exploring new path to weight loss — minus side effects

The most effective obesity medications of today — GLP-1 drugs such as Ozempic and Wegovy — come with significant side effects, most commonly nausea and vomiting. Researchers in the UK College of Pharm...

uknow.uky.edu

uknow.uky.edu/uk-healthcar...

Keeneland investigator finds healing and humor in heart surgery at UK

On an early morning drive to Keeneland, Billy Fryer felt a pain in his chest he had never felt before. Thanks to UK HealthCare’s partnership with Keeneland and the compassionate work of his care team,...

uknow.uky.edu

Excited to be working with Jonathan Wenk (University of Kentucky) and Lik-Chuan Lee (Michigan State University) on computer modeling of cardiac fibrosis. uknow.uky.edu/research/uk-...

UK engineering researcher leads NSF‑funded initiative to model heart fibrosis with machine learning

Researchers in the Stanley and Karen Pigman College of Engineering at the University of Kentucky are teaming up with researchers at Michigan State University to develop cutting-edge simulations of hea...

uknow.uky.edu

🎉 TRPA1-derful news 🎉 Dr. Dan Conklin has been successful in obtaining AHA funding to explore how inhaled anesthetics affect cardiorespiratory function through Transient Receptor Potential Ankyrin-1 (TRPA1). #AHA #TeamConklin #TRPA1 #cardiosky @ahascience.bsky.social @uoflenvirome.bsky.social

Great talk by Greg Sawicki at #AMAM2025 on tuning series elastic stiffness (e.g. tendon) in legged locomotion.

Congratulations to Dr. Marcin Wysoczynski, Associate Professor in the Center, on his appointment to the Editorial Board of Circulation Research. Well done, Dr. Wysoczynski. @ahajournals.bsky.social #cardiosky

Our department @ucph.bsky.social is looking for a new faculty member! This is a nice environment for an ambitious PI with a research focus on cardiovascular system, metabolism and/or drug discovery! Happy to answer questions if you are interested!

164414 Tenure Track Assistant Professor or Associate Professor of Biomedical Sciences

jobportal.ku.dk

Congrats to Drs. Kampourakis, McDonald, Root and their collaborators on this cool study. Always excited to see new modulators of sarcomere function. Modulation of striated-muscle contractility by a high-affinity myosin-targeting peptide: Biophysical Journal www.cell.com/biophysj/ful...

Modulation of striated-muscle contractility by a high-affinity myosin-targeting peptide

Myosin-based regulation has emerged as a fundamental new concept governing both cardiac and skeletal muscle contractile function during both health and disease states. Myosin-targeted therapeutics hav...

cell.com

The Collins lab welcomed Nora Anderson to the team today. Nora joins as a research technician, who will assist with our ongoing pregnancy studies. 🫀🤰#cardiosky

Congratulations to Avery Kendall for their first of many papers being accepted for publication today. Watch this space for the next one! #cardiosky @apspublications.bsky.social

Aurora Scientific is #hiring a Life Science Product Consultant. This position is dedicated to building and maintaining a lasting relationship with our customers by conducting sales and post-sales support activities. Apply now! ca.indeed.com/viewjob?jk=6...

Helping to raise awareness for women’s cardiovascular health at the 2025 Kentuckiana AHA Go Red For Women Luncheon @ahascience.bsky.social