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Lyssiotis Lab

@lyssiotislab.bsky.social

Cancer and Immune Metabolism Research Laboratory, University of Michigan

102 Posts4255 Follower319 Folgt
Nature Metabolism@natmetabolism.nature.com · 3mo ago

RESEARCH | Y Shah, H Crawford, @lyssiotislab.bsky.social et al. (U of Michigan): Disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions 🧪

NADPH-producing enzymes restrict the formation of pancreatic precancerous lesions - Nature Metabolism

Temporal profiling of central carbon metabolism during KrasG12D-driven acinar-to-ductal metaplasia reveals that disruptions in NADPH-producing enzymes accelerate the formation of pancreatic precancerous lesions.

dlvr.it

Lyssiotis Lab@lyssiotislab.bsky.social · 4mo ago

New study from the lab 🧵 1/ Pancreatic cancer is metabolically rewired and immunosuppressive. We asked: can targeting metabolism trigger immunogenic cell death (ICD) to boost anti-tumor immunity? Key twist: ferroptosis shows ICD signals in vitro, but is largely tumor-protective in vivo rdcu.be/fc55T

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Dr. Becca@docbecca.bsky.social · 7mo ago

Just spoke to The Hill about how the dismantling of the NIH is impacting science in America. We still face a cliff of unfathomable heights, w easily 1000+ labs poised to close in the next year due to funding ending. A generation of young scientists lost because there is nowhere for them to train.

Nature Metabolism@natmetabolism.nature.com · 10mo ago

#NatMetabPicks | In @nature.com led by @danwahlmd.bsky.social‬ @lyssiotislab.bsky.social @dnagrathlab.bsky.social WN Al-Holou ( @umich.edu ) Gliomas take up serine from the tumor microenvironment, and can be targeted with dietary serine restriction. 🧪 www.nature.com/articles/s41...

Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources such as environmental amino acids, providing a potential therapeutic target.

nature.com

The New York Times@nytimes.com · 10mo ago

In @nytopinion.nytimes.com The Trump administration’s autism project “is built on the premise that an autism diagnosis is a terrible tragedy and that scientists and doctors have failed,” Roy Grinker, a cultural anthropologist and the father of an autistic child, says. “But science has not failed.”

Opinion | Autism Has Never Been One Thing

We’ve come too far to go back to a time when autism was defined solely in terms of deficits and mothers were made to feel guilty.

nyti.ms

Dan Wahl@danwahlmd.bsky.social · 11mo ago

New discovery from our team defining how human brain cancers rewire the metabolism of the normal brain published this week @nature.com and led by stellar postdoc Drew Scott (comentored by @lyssiotislab.bsky.social and currently on job market with a K99/R00). www.nature.com/articles/s41...

Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...

nature.com

Christian Frezza@frezzalab.bsky.social · 11mo ago

Rewiring of cortical glucose metabolism fuels human brain cancer growth www.nature.com/articles/s41... Congrats to the many involved, including @lyssiotislab.bsky.social and @dnagrathlab.bsky.social

Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature

The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...

nature.com

Ananya Sen@ana-sen.bsky.social · 11mo ago

A massive team effort by U-M researchers have found that glioblastoma cells rewire how they use sugar, which can be targeted in mice to slow tumor growth and improve treatment responses. @lyssiotislab.bsky.social @dnagrathlab.bsky.social Learn more: michmed.org/MD2X2.

Dietary changes could provide a therapeutic avenue for brain cancer

A team of researchers from Michigan Medicine tracked how glucose is used in glioblastoma tumor cells. They showed that dietary interventions can slow brain cancer growth in mice.

michmed.org

Caitlin Gilbert@caitlingilbert.bsky.social · 11mo ago

Three senior leaders who resigned in protest told The Post they were asked to participate in an unscientific vaccine recommendation process that they believe could harm the health of Americans. More from @lenasun.bsky.social @laurenweberhp.bsky.social @davidovalle.bsky.social 🎁: wapo.st/46aNJB0

CDC leaders who resigned said RFK Jr. undermined vaccine science, risking lives

As the CDC reels from departures, White House appoints Jim O’Neill as acting director.

wapo.st

Caroline Bartman@cbartman.bsky.social · 11mo ago

Ok so does anyone know anything about the NSF GRFP? Has anyone made any statement? Grad students keep telling me they’re writing it and I’m like discouraging them from spending time on this…. But do we have any actual information?

Lyssiotis Lab@lyssiotislab.bsky.social · 11mo ago

Our department is recruiting a new tenure track Assistant/Associate Professor. Come join the #1 physiology department in the country and some awesome colleagues doing high impact science and training the next generation of scientists jobs.sciencecareers.org/job/674815/a...

Assistant/Associate Professor - Tenure Track - Physiology - University of Michigan, Ann Arbor job with University of Michigan Department of Molecular & Integrative Physiology | 674815

Tenure track assistant/associate professor in the Department of Molecular & Integrative Physiology at the University of Michigan Medical School.

jobs.sciencecareers.org

HHMI@hhmi-science.bsky.social · 12mo ago

Congratulations 2025 Gilliam Fellows and Advisors! 🎉 The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments. Through this program, HHMI supports both graduate students and their faculty thesis advisors.

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@ja-nietocarrion.bsky.social · 12mo ago

I am so happy to join the HHMI Gilliam community, keep working in cancer metabolism, and continuing my passions in scientific outreach and communication! Huge thanks to all of my current and past mentors! @lyssiotislab.bsky.social, @ajdiazphd.bsky.social, Dr. Yatrik Shah

HHMI@hhmi-science.bsky.social · 12mo ago

Congratulations 2025 Gilliam Fellows and Advisors! 🎉 The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments. Through this program, HHMI supports both graduate students and their faculty thesis advisors.

Cassie Clarke@cassiejclarke.bsky.social · last yr.

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Uridine phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes | EMBO reports

imageimageMetastatic primary tumours upregulate Upp1 in neutrophils, which elevates circulating uracil. UPP1-expressing neutrophils accumulate in the lung where they inhibit CD8+ T cells, promote fibr...

embopress.org

Lyssiotis Lab@lyssiotislab.bsky.social · last yr.

So grateful and excited to partner with the Stephenson Global Pancreatic Cancer Research Institute to advance our collaborative program targeting lysosome and Kras metabolism in pancreatic cancer! michmed.org/rwVDK

Lyssiotis awarded Stephenson Global Scholar Grant for pancreatic cancer research

Costas Lyssiotis, Ph.D., co-director of the Rogel and Blondy Center for Pancreatic Cancer at the Rogel Cancer Center, was one of six researchers to receive inaugural grants from the Stephenson Global ...

michmed.org