I did it. Phew. 🏃‍♂️ I completed the Silverstone half marathon, raising money for Race Against Dementia. Still time to donate if you have a spare £. www.givengain.com/project/char...

If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...

What Rosalind Franklin truly contributed to the discovery of DNA’s structure

Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.

nature.com

and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz

Catching changes in morphology of your human pluripotent stem cell (hPSC) maintenance cultures early helps ensure reproducible, reliable experiments. But what should you look for?

✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells

Thank you @alzsocresearch.bsky.social and @dementiaresearcher.bsky.social for chatting with me about our recent paper. So grateful for all the coauthors and mentors who made this work possible. Certainly a team effort!

@alzsocresearch.bsky.social · 11mo ago

"It’s been fantastic to come up with an idea... and have an output like this." On @dementiaresearcher.bsky.social, we spoke to Dr Charlie Arber @celarber.bsky.social about his first senior author paper from his Alzheimer's Society funded fellowship: www.dementiaresearcher.nihr.ac.uk/blog-first-a...

Eeek. I've signed up to run my first ever half marathon, raising money for Race Against Dementia, funders for research into dementia. Any contributions very much appreciated and any tips even more so! 🏃‍♂️🍝 www.givengain.com/project/char...

Join Me in the Race Against Dementia

I’m excited to run my first half marathon around the track at Silverstone. I am doing this to support Race Against Dementia, a charity that holds special significance for me and which began with Sir J...

givengain.com

Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, a study by @uclqsion.bsky.social researchers found. buff.ly/dBRRQvY #WorldAlzheimersMonth

Key differences between visual- and memory-led Alzheimer’s discovered

Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, finds a new…

ucl.ac.uk

🧠 This #WorldAlzheimersMonth, discover how UCL’s AI tool SuStaIn is transforming Alzheimer’s diagnosis and care—by identifying subtypes and predicting progression from just a snapshot of data. buff.ly/DmzYSlb @uclengineering.bsky.social

Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease. www.biorxiv.org/content/10.1... Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi

Excited contribute to this year’s lunch hour lecture program! It’s a free event and accessible to a non-specialist audience so please come and join me :)

UCL Faculty of Brain Sciences@uclbrainscience.bsky.social · 12mo ago

🧠 What if we could watch dementia unfold in a dish—and stop it before it starts? Join Prof @selinawray.bsky.social (@uclqsion.bsky.social) on 18 Sept for a free @UCL Lunch Hour Lecture exploring the future of dementia research. 📅 1–2pm | 💻 Online 🔗 www.ucl.ac.uk/events/event...

Post a non-religious photo you think of as holy

Current Biology@currentbiology.bsky.social · 12mo ago

Post a non-religious photo you think of as holy.

These are the most challenging times for early-career scientists and engineers. My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers. We found 437 of them. Download it freely here: research.jhu.edu/rdt/funding-...

I’m a huge fan of the work done by @typlab.bsky.social - so it was great to have the opportunity to write a preview of their work describing an in vitro triculture model of Alzheimer’s (with @celarber.bsky.social & Tatiana). Check it out & go read their paper! www.sciencedirect.com/science/arti...

Reconstructing Alzheimer’s disease one cell type at a time using in vitro tricultures

In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes,…

sciencedirect.com

What a treat to share a walkies and a BBQ with my colleagues. The rain in the background caught us on the way home. But that’s normal for a British bbq, right?

💊 First ever treatment for Friedreich’s ataxia – for which @uclqsion.bsky.social and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator. buff.ly/3dSwwzJ #ResearchersAppreciationDay

First treatment for rare disease approved by UK medicines regulator

The first ever treatment for the rare neurodegenerative disease Friedreich’s ataxia – for which UCL and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator.

ucl.ac.uk

'Stem Cells in Neuroscience' is returning to Tübingen, Germany. SAVE THE DATE: February 25-27, 2026. More info: stemcelltuebingen.com Please share #stemcelltuebingen2026 @dzne.science @hih-tuebingen.bsky.social @unituebingen.bsky.social @tueneurocampus.bsky.social

Currently listening to Mina Ryten (@ukdri.ac.uk) describing advances towards improved transcriptomic maps, providing new insights into variant to function for Alzheimer’s disease 🧠 #MilnerSymp25

I've been really hoping to see more manuscript threads here on 🦋, so here comes one!!! This is brand new work from the lab that took us in very unexpected directions and to exciting findings led by the amazing @emily-hill.bsky.social. Preprint here www.biorxiv.org/content/10.1... and 🧵below:

It's out! More than just making amyloid? What if mutations in PSEN1 also predispose inflammation. We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. molecularneurodegeneration.biomedcentral.com/articles/10.....

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration

Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

molecularneurodegeneration.biomedcentral.com

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

sciencedirect.com

'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis' Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social‬‬ molecularneurodegeneration.biomedcentral.com/articles/10....

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration

Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

molecularneurodegeneration.biomedcentral.com

New paper from the lab, under the leadership of @celarber.bsky.social !

Molecular Neurodegeneration@molneurodegen.bsky.social · last yr.

'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis' Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social‬‬ molecularneurodegeneration.biomedcentral.com/articles/10....

🚨🚨Job Alert🚨🚨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept! @ucl.ac.uk @ucllifesciences.bsky.social @uclnpp.bsky.social post here: www.nature.com/naturecareer...

Lecturer / Associate Professor - London, England job with University College London (UCL) | 12840324

About usThe Division of Biosciences at UCL is one of the world's foremost centres for research and teaching in the biological sciences. We have an out

nature.com

Wow. What does this mean for Alzheimer’s disease? 🧐

Science News@scinews.bsky.social · last yr.

Helicobacter pylori CagA protein is a potent and broad-spectrum amyloid inhibitor 🎯Unexpected discovery: H. pylori CagA strongly blocks amyloid formation with a broad substrate spectrum. Open Access www.science.org/doi/10.1126/...

We are excited to be recruiting 3 post-doctoral researchers to study glial cell dysfunction in #agingresearch and #neurodegeneration, including one position using #Drosophila models! If you are interested, please read more below to get in touch or apply (links in thread).

Wonderful team. You’d be a fool not to apply

Dementia Researcher@dementiaresearcher.bsky.social · last yr.

Join the UKDRI at UCL in the Salih Lab to explore how glial-specific longevity genes affect ageing and Alzheimer’s, using iPSC models, genomics, and molecular biology @ukdri.ac.uk @dervissalih1.bsky.social Closing date: 26th June www.dementiaresearcher.nihr.ac.uk/job/research...

Excited to share a new preprint from our collaborative work led by Emil Gustavsson, Mina Ryten & @celarber.bsky.social - we used long read sequencing to identify novel APP transcripts that are competent to generate Abeta www.biorxiv.org/content/10.1...

Independent Generation of Amyloid-β via Novel APP Transcripts

The amyloid precursor protein (APP) is processed by multiple enzymes to generate biologically active peptides, including amyloid-β (Aβ), which aggregates to form the hallmark pathology of Alzheimers d...

biorxiv.org

What if cells could make amyloid-beta without having to make the rest of APP? Transcripts that code for cleavage fragments of APP can't be a coincidence! Great collaboration between us @selinawray.bsky.social and Mina and Emil where longread seq keeps surprising us www.biorxiv.org/content/10.1...

Independent Generation of Amyloid-β via Novel APP Transcripts

The amyloid precursor protein (APP) is processed by multiple enzymes to generate biologically active peptides, including amyloid-β (Aβ), which aggregates to form the hallmark pathology of Alzheimers d...

biorxiv.org

A nice read and ICYMI here is our cited paper from the end of last year on the microglia contribution to Familial British Dementia: link.springer.com/article/10.1...

Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia - Acta Neuropathologica

Mutations in ITM2B cause familial British, Danish, Chinese, and Korean dementias. In familial British dementia (FBD), a mutation in the stop codon of the ITM2B gene (also known as BRI2) causes a C-ter...

link.springer.com

Molecular Neurodegeneration@molneurodegen.bsky.social · last yr.

'Evidence suggesting that #microglia make #amyloid from neuronally expressed APP: a hypothesis' John Hardy & Patrick Lewis molecularneurodegeneration.biomedcentral.com/articles/10....