Lea H. Gregersen

@gregersenlab.bsky.social

Group leader at @UCPH_health, working on RNA-binding proteins and co-transcriptional regulation. Previously at @UPCH_BRIC, @BIMSB_MDC and @TheCrick

What is the function of the RNAPII-interacting SCAF proteins? In our latest work, led by Smaragda Kompocholi, we show that SCAF1 shapes mRNA isoform expression during neuronal differentiation 🧬 🧠 Loss of SCAF1 → shorter transcripts 📄 Interested in the full story? www.biorxiv.org/content/10.6...

SCAF1 driven polyadenylation site usage regulates mRNA isoform expression and neuronal differentiation

Accurate co-transcriptional processing is required for correct gene expression of mRNA transcript isoforms under unperturbed conditions, but particularly during development, to ensure tissue-specific ...

biorxiv.org

What happens to transcription upon oxidative DNA damage? 🧬💥 RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦 👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...

Oxidative stress triggers RNAPII arrest through PARylation and DNA damage

UV or gamma irradiation, as well as certain chemicals, generate DNA damage that disrupts transcription through a variety of well-characterised mechanisms. In contrast, the transcriptional response to ...

biorxiv.org

Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure rates across 3,000+ genes 🧬 genome.cshlp.org/content/earl... This fantastic work led by Haiyue Liu reveals gene and intra-genic variation, links to histone marks & elongation factors Details below! 👇

Kinetic measurement of gene-specific RNA polymerase II transcription elongation rates

An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

genome.cshlp.org