Charlène Boumendil (She/Her)
@charleneboumendil.bsky.social
Group leader @Institute of Human Genetics, chromatin lover, inclusive feminist, mother of three.
New version of our preprint, led by amazing PhD students, Zoé and Stefany: disordered-like physical properties of TPR mediated by its coiled coil (!) and negatively regulated by its disordered domain (!) triggers heterochromatin exclusion and a new permeability barrier at nuclear pore basket (!)
Disorder in coiled-coils orchestrate chromatin organization and define a new permeability barrier at the nuclear pore basket
Nuclear pore complexes are the only gateway between the nucleus and cytoplasm in eukaryotic cells during interphase. Specificity of transport is ensured by a size-dependent permeability barrier, which...
biorxiv.org
Out now in Science! Our study challenges long-standing assumptions about transcription factor specificity in eukaryotes. Novel single-molecule measurements of TF behavior in living cells reveal an independence of locus-specific binding from DNA sequence recognition.🧵 www.science.org/doi/10.1126/...
Unstructured transcription factor interactions enable emergent specificity
How intrinsically disordered regions (IDRs) shape chromatin binding and nuclear organization of transcription factors (TFs) remains unclear. We used proximity-assisted photoactivation (PAPA), a single...
science.org
Congrats @eliasfriman.bsky.social and all!!!
Wendy Bickmore@wbickmor.bsky.social · 4mo agoAlthough cohesin-sensitive, long-range enhancer activation is equivalent in nature to proximal activation. Cooperativity can arise from different levels of activation inputs operating on a non-linear response function. @eliasfriman.bsky.social @uoe-igc.bsky.social www.biorxiv.org/content/10.6...
🎉 Now online! The Annual Review of Biophysics is now online. The most read article is "The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms" by Villalta et. arevie.ws/3R2CANN @sashiw.bsky.social @nucleosomepolice.bsky.social
First day of my PhD in IGBMC, internal seminar. An old man is sitting on the stairs. The talk ends and the old man asks a simple question, yet the most important and smart one. I turned to my colleague next to me: « Who is he? » That was Pierre Chambon. Incredibly smart, always exactly on point.
Alexis Verger 🧬🧫🧪@alexis-verger.cpesr.fr · 4mo ago#RIP Pierre Chambon (1931-2026) 1963 PARP 1970 RNA Pol II 1975 Nucleosome 1977 Split genes 1980 Promoter 1983 enhancer 1986 Nuclear receptor
Exciting!
Anders Sejr Hansen@andersshansen.bsky.social · 4mo ago(1/n) Super excited to share that our preprint is out today in @natsmb.nature.com with a new name "Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types" and more than 2x more data: www.nature.com/articles/s41... See also MIT News news.mit.edu/2026/how-chr...
One week left to apply to join us in sunny Montpellier as a group leader!
Charlène Boumendil (She/Her)@charleneboumendil.bsky.social · 6mo agoWe are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...
Kudos to @nadinelaguette.bsky.social team and all co-authors on this nice paper where our lab had a modest contribution! @viroscope.bsky.social 🔥
Journal of Experimental Medicine@jem.org · 6mo agoVila, Messaoud-Nacer, Taffoni, @nadinelaguette.bsky.social et al show that DNA-PKcs, a major DNA damage response actor, interacts w/ cyclic dinucleotides through its kinase domain, ensuring CDN-associated signal termination, while CDNs inhibit DNA-PKcs catalytic activity rupress.org/jem/article/...
We are looking for a new group leader to join the IGH (Montpellier, France). I can’t wait to meet my future colleague! Apply :-) More infos here: igh.cnrs.fr/join-igh-as-...
Join IGH as Group Leader - IGH
The Institute of Human Genetics invites applications for a Principal Investigator position in its main research areas. Read more...
igh.cnrs.fr
Sad to hear that Pat Jacob has died aged 91. Pat was a seminal figure in the early days of human genetics. She co-discovered the 1st human chromosome abnormality - XXY Kleinfelter's syndrome in 1959, published contemporaneously with the discovery of trisomy 21 in Down’s syndrome by a French group.
Beautiful work by @fpaldi.bsky.social, Giacomo Cavalli and team. A must read!!!
It is my great pleasure to welcome my new colleague Sora Yang in IGH! Can’t wait for the great collaborations ahead!
Exciting opportunity to join the vibrant Montpellier scientific community!
CRBM-Montpellier@crbm-montpellier.bsky.social · 7mo agoWe are hiring!
Delighted to have a contribution in this issue together with @eliasfriman.bsky.social
Alexis Verger 🧬🧫🧪@alexis-verger.cpesr.fr · 8mo agoThere is a special Current Opinion in Genetics & Development issue about genome architecture and expression and it looks great including reviews by @lennarthilbert.bsky.social @yghavi.bsky.social and @wbickmor.bsky.social www.sciencedirect.com/special-issu...
Hello everybody, I am looking for an Engineer (IE) to help me start the lab at LBMC / ENS-Lyon in April. We will investigate chromatin organization during replication in yeast. RT appreciated! To apply: inserm.softy.pro/offre/187863 @lbmcinlyon.bsky.social #NewPI #3DGenome #chromatin #replication
Very happy to share our technical paper led by our fantastic research assistant, Axelle Donjon, in which we share our image analysis pipeline to study nucleocytoplasmic transport dynamics using LEXY and LINuS (tools from the di Ventura lab). Thread below! www.jove.com/t/68585/usin...
Using LEXY and LINuS Optogenetics Tools and Automated Image Analysis to Quantify Nucleocytoplasmic Transport Dynamics in Live Cells
Université de Montpellier, CNRS, UMR9002. This protocol describes how to efficiently set up and perform automated analyses of live cell imaging data obtained from tracking the nucleocytoplasmic trans...
jove.com
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
nature.com
Congrats to my friends in the Boettiger lab for this really beautiful live imaging work. A big leap forward in understanding the dynamic side of genome organization. www.science.org/doi/10.1126/...
Kinetic organization of the genome revealed by ultraresolution multiscale live imaging
Genome function requires regulated genome motion. However, tools to directly observe this motion in vivo have been limited in coverage and resolution. Here we introduce an approach to tile mammalian c...
science.org
My lab @mpi-muenster.bsky.social is looking for a computational biologist with a passion for imaging and spatial biology. A staff scientist position with long-term perspective! Apply and spread the word 🙏 jobs.mpi-muenster.mpg.de/jobposting/0...
Computational image analyst (m/f/d)
The Max Planck Institute for Molecular Biomedicine in Münster, Germany, has an opening for a
jobs.mpi-muenster.mpg.de
Fantastic recognition for seminal work in the phase séparation field. And guess what? Work from the Gohrlich lab focuses on my favourite compartment: The nuclear pore complexes! I told you they are fascinating!
Albert and Mary Lasker Foundation@laskerfdn.bsky.social · 12mo agoCongratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪 @mpi-nat.bsky.social #Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
I am happy, excited and very humbled to have obtained an ERC starting grant to study the interplay betweeen nuclear pores and chromatin organization! Keep posted for job advertisements and pretty microscopy pictures ;-)
European Research Council (ERC)@erc.europa.eu · last yr.📣 The ERC Starting Grant call results are out! Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025! ➡️ buff.ly/IsafuFh #FrontierResearch 🇪🇺#EUfunded #HorizonEurope
It is with infinite sadness that we learned of the passing of Clarisse Orniacki. She joined @vdoye.bsky.social lab and defended her thesis in December 2022 and pursued her career with a postdoc in @tedfon.bsky.social at McGill University in Montreal . Tribute 🔗 www.ijm.fr/tribute-to-c...
The nuclear lamina strengthens the nucleus and organizes the genome. So what happens when you acutely degrade it in living cells? Not what we thought! (1/n) www.molbiolcell.org/doi/10.1091/...
Lamin B1 and LAP2β resist cytoskeletal force to maintain lamin A/C meshwork organization and preserve nuclear integrity | Molecular Biology of the Cell
The nuclear lamins are extremely long-lived proteins in most cell types. As a consequence, lamin function cannot be effectively dissected with temporal precision using standard knock-down approaches. ...
molbiolcell.org
Very excited to share the first preprint of the lab! We show that the nuclear pore protein TPR forms biomolecular condensates which keep heterochromatin away from the nuclear pore complexes and maintains global chromatin organization. Check it out, share it, tell us what you think!!
bioRxiv Cell Biology@biorxiv-cellbio.bsky.social · last yr.Biomolecular condensates at the nuclear pore basket maintain global chromatin organization https://www.biorxiv.org/content/10.1101/2025.07.18.665545v1
